| 1. |
- Al-Chalabi, Ammar, et al.
(författare)
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July 2017 ENCALS statement on edaravone
- 2017
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Ingår i: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. - : TAYLOR & FRANCIS LTD. - 2167-8421 .- 2167-9223. ; 18:7-8, s. 471-474
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Tidskriftsartikel (refereegranskat)abstract
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| 2. |
- Kuzmenko, Volodymyr, 1987, et al.
(författare)
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Capacitive effects of nitrogen doping on cellulose-derived carbon nanofibers
- 2015
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Ingår i: Materials Chemistry and Physics. - : Elsevier BV. - 0254-0584. ; 160, s. 59-65
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Tidskriftsartikel (refereegranskat)abstract
- Carbons with valuable electrochemical characteristics are among the most convenient electrode materials used for energy storage. At the moment, their production is mostly reliant on unsustainable fossil fuels. A preferential sustainable production of enhanced carbonaceous electrodes can be achieved with more extensive utilization of abundant renewable resources instead of fossils. In this study, nitrogen-doped carbon nanofibers (CNFs) were synthesized from cellulose, the most abundant renewable resource, via consecutive steps of cellulose acetate electrospinning, subsequent deacetylation to cellulose, impregnation with nitrogen-containing additive (ammonium chloride), and carbonization. Results of material characterization showed that the carbonization of functionalized cellulose samples led to formation of CNFs doped with 4–5.6 at.% of nitrogen. In comparison with pristine CNFs N-doped samples had a slightly lower specific surface area, but higher conductivity and hydrophilicity. Moreover, electrochemical measurements indicated that the enhanced N-doped materials had about 2.5 times higher specific capacitance which was increasing throughout 1000 charge–discharge cycles. These results suggest that nitrogen doping method used in this study has a positive pseudocapacitive effect on the electrochemical performance of carbonized cellulose materials.
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| 3. |
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| 4. |
- Kuzmenko, Volodymyr, 1987, et al.
(författare)
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Carbon nanotubes/nanofibers composites from cellulose for supercapacitors
- 2014
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Ingår i: 16th European Conference on Composite Materials, ECCM 2014; Seville; Spain; 22 June 2014 through 26 June 2014.
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Konferensbidrag (refereegranskat)abstract
- Cellulose-based carbon nanofibers (CNFs) with high mechanical strength and electrochemical stability were nitrogen-doped and functionalized with carbon nanotubes (CNTs) via two different methods. The diameter of incorporated CNTs was in the range of 1-20 nm. The doping with nitrogen atoms and incorporation of CNTs into the CNFs improved conductivity, while CNTs also increased surface area of the produced material. As a result, the composite materials with capacitance values up to 241 F/g were obtained.
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| 5. |
- Kuzmenko, Volodymyr, 1987, et al.
(författare)
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Sustainable carbon nanofibers/nanotubes composites from cellulose as electrodes for supercapacitors
- 2015
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Ingår i: Energy. - : Elsevier BV. - 0360-5442 .- 1873-6785. ; 90:2, s. 1490-1496
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Tidskriftsartikel (refereegranskat)abstract
- Supercapacitors are efficient energy storage devices with long lifetime and safe service. Their effectiveness,to a big extent, is dependent on electrode materials used for accumulation of energy in form ofelectrostatic charges. Over the last decades, variety of carbonaceous electrode materials has been used insupercapacitors. Mostly the production of such electrodes is still oriented on unsustainable fossil fuels asprecursors instead of sustainable renewable resources. In this study, freestanding carbonaceous electrodematerials for supercapacitors were derived from cellulose, the most abundant renewable resource. Theywere synthesized via carbonization of fibrillar cellulose impregnated with CNTs (carbon nanotubes). Theensuing composite materials consisted of a CNF (carbon nanofiber) scaffold (fiber diameter in the rangeof 50-250 nm) covered with layers of CNTs (tube diameter in the range of 1-20 nm). Moreover, thesecomposites were tested as electrode materials for supercapacitors. Incorporation of the CNTs into theCNFs improved electrical conductivity and also increased the surface area of the produced compositematerials, which led to high specific capacitance values (up to 241 F/g), cyclic stability, and powerdensity of these materials in electrochemical measurements. These results suggest that cellulose-derivedoriginal CNF/CNT composites are sustainable and efficient carbonaceous electrodes for supercapacitors.
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| 6. |
- Lindgren, Arne, et al.
(författare)
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Clinical lacunar syndromes as predictors of lacunar infarcts. A comparison of acute clinical lacunar syndromes and findings on diffusion-weighted MRI
- 2000
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 1600-0404 .- 0001-6314. ; 101:2, s. 128-134
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To evaluate if patients with acute lacunar syndromes have acute lacunar infarcts or other types of cerebral lesions on diffusion-weighted MRI. METHODS: Patients with acute lacunar syndromes underwent echo-planar diffusion MRI of the brain within 3 days after stroke onset. Localization and size of lesions with hyperintense signal were determined, compared with clinical characteristics and with findings on follow-up T2-weighted MRI. RESULTS: Twenty-three patients participated in the study. Thirteen patients had pure motor stroke, 1 pure sensory stroke, 8 sensorimotor stroke, and 1 ataxic hemiparesis. Twenty-two patients had at least one lesion with increased signal on diffusion-weighted MR images. These acute lesions were in the internal capsule/ basal ganglia/thalamus in 13 patients, subcortical white matter in 5 patients, brainstem in 2 patients, cortex (multiple small lesions) in 1 patient, and cortex + basal ganglia in 1 patient. The median volume of the lesions was 0.6 ml on the initial examination and on follow-up, of 17 patients after 1 to 5 months, 0.5 ml. CONCLUSIONS: Almost all patients with acute ischemic lacunar syndromes have acute lesions on echo-planar diffusion-weighted MRI within 3 days after stroke onset. These lesions are mostly small and subcortical, compatible with lacunar infarcts caused by single penetrating artery occlusion, but in a minor proportion of patients (2 of 23 in our study) a cortical involvement is found.
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| 7. |
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| 8. |
- Nik-Zainal, Serena, et al.
(författare)
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Landscape of somatic mutations in 560 breast cancer whole-genome sequences
- 2016
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 534:7605, s. 47-54
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Tidskriftsartikel (refereegranskat)abstract
- We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended to genome rearrangements and revealed twelve base substitution and six rearrangement signatures. Three rearrangement signatures, characterized by tandem duplications or deletions, appear associated with defective homologous-recombination-based DNA repair: one with deficient BRCA1 function, another with deficient BRCA1 or BRCA2 function, the cause of the third is unknown. This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operating, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
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| 9. |
- Smid, Marcel, et al.
(författare)
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Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example, TP53, PIK3CA, PTEN, CCND1 and CDH1. We find that CCND3 expression levels do not correlate with amplification, while increased GATA3 expression in mutant GATA3 cancers suggests GATA3 is an oncogene. In luminal cases the total number of substitutions, irrespective of type, associates with cell cycle gene expression and adverse outcome, whereas the number of mutations of signatures 3 and 13 associates with immune-response specific gene expression, increased numbers of tumour-infiltrating lymphocytes and better outcome. Thus, while earlier reports imply that the sheer number of somatic aberrations could trigger an immune-response, our data suggests that substitutions of a particular type are more effective in doing so than others.
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| 10. |
- Smid, Marcel, et al.
(författare)
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The circular RNome of primary breast cancer
- 2019
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Ingår i: Genome Research. - : Cold Spring Harbor Laboratory. - 1088-9051 .- 1549-5469. ; 29:3, s. 356-366
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Tidskriftsartikel (refereegranskat)abstract
- Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs that does not rely on unmapped reads or known splice junctions. We identified 95,843 circRNAs, of which 20,441 were found recurrently. Of the circRNAs that match exon boundaries of the same gene, 668 showed a poor or even negative (R <0.2) correlation with the expression level of the linear gene. In silico analysis showed only a minority (8.5%) of circRNAs could be explained by known splicing events. Both these observations suggest that specific regulatory processes for circRNAs exist. We confirmed the presence of circRNAs of CNOT2, CREBBP, and RERE in an independent pool of primary breast cancers. We identified circRNA profiles associated with subgroups of breast cancers and with biological and clinical features, such as amount of tumor lymphocytic infiltrate and proliferation index. siRNA-mediated knockdown of circCNOT2 was shown to significantly reduce viability of the breast cancer cell lines MCF-7 and BT-474, further underlining the biological relevance of circRNAs. Furthermore, we found that circular, and not linear, CNOT2 levels are predictive for progression-free survival time to aromatase inhibitor (AI) therapy in advanced breast cancer patients, and found that circCNOT2 is detectable in cell-free RNA from plasma. We showed that circRNAs are abundantly present, show characteristics of being specifically regulated, are associated with clinical and biological properties, and thus are relevant in breast cancer.
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