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- Kawahara, R., et al.
(författare)
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Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis
- 2021
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Ingår i: Nature Methods. - : Springer Science and Business Media LLC. - 1548-7091 .- 1548-7105. ; 18, s. 1304-1316
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Tidskriftsartikel (refereegranskat)abstract
- Glycoproteomics is a powerful yet analytically challenging research tool. Software packages aiding the interpretation of complex glycopeptide tandem mass spectra have appeared, but their relative performance remains untested. Conducted through the HUPO Human Glycoproteomics Initiative, this community study, comprising both developers and users of glycoproteomics software, evaluates solutions for system-wide glycopeptide analysis. The same mass spectrometrybased glycoproteomics datasets from human serum were shared with participants and the relative team performance for N- and O-glycopeptide data analysis was comprehensively established by orthogonal performance tests. Although the results were variable, several high-performance glycoproteomics informatics strategies were identified. Deep analysis of the data revealed key performance-associated search parameters and led to recommendations for improved 'high-coverage' and 'high-accuracy' glycoproteomics search solutions. This study concludes that diverse software packages for comprehensive glycopeptide data analysis exist, points to several high-performance search strategies and specifies key variables that will guide future software developments and assist informatics decision-making in glycoproteomics. This analysis presents the results of a community-based evaluation of existing software for large-scale glycopeptide data analysis.
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| 2. |
- Benedikt, M., et al.
(författare)
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Conceptual design report for a Beta-Beam facility
- 2011
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 47:2
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Forskningsöversikt (refereegranskat)abstract
- The Beta-Beam is a concept of large-scale facility that aims at providing pure electronic neutrino and antineutrino beams for the measurement of v(e) -> v(mu) oscillations. Beta-decaying nuclides are produced in large amounts in a facility of the scale of EURISOL, and are then post-accelerated and stored at large gamma in a racetrack decay ring. We present here a conceptual design of the accelerator chain of a Beta-Beam based at CERN.
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| 6. |
- Poetzelsberger, B., et al.
(författare)
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Alpine Skiing With total knee ArthroPlasty (ASWAP) : effects on strength and cardiorespiratory fitness
- 2015
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Ingår i: Scandinavian Journal of Medicine and Science in Sports. - : Wiley. - 0905-7188 .- 1600-0838. ; 25, s. 16-25
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated the effect of a 12-week recreational skiing intervention on lower limb muscle strength and cardiorespiratory fitness in participants with unilateral total knee arthroplasty (TKA). Twenty-seven older adults (70 +/- 5 years) were assigned to the intervention (n=13) or control group (n=14) after surgery (2.5 +/- 1 years). Leg muscle strength was measured using an IsoMed 2000 dynamometer and cardiorespiratory fitness was determined by cycle ergometry before and after the intervention as well as after an 8-week retention period. The skiing intervention led to increased muscle strength in the operated leg during unilateral single joint isometric extension (maximal force: 11%; P<0.05; rate of torque development: 24%; P<0.05) and during the unilateral multi-joint isokinetic single leg strength test (8%; P<0.05). This resulted in a decreased asymmetry index in the isokinetic test (13% to 5%; P<0.05). These adaptations remained unchanged toward the retention test. No effect was observed for cardiorespiratory fitness. The results demonstrate that muscle contraction forces required during recreational skiing in individuals with TKA seem adequate and effective to increase quadriceps and hamstrings muscle strength in the initially weaker operated leg and to reduce an augmented post-operative asymmetry index.
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| 8. |
- Seidel, M., et al.
(författare)
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Improving the energy efficiency of accelerator facilities
- 2015
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Konferensbidrag (refereegranskat)abstract
- New particle accelerator based research facilities tend to be much more productive, but often in coincidence with higher energy consumption. The total energy consumption of mankind is steeply rising and this is mainly caused by quickly developing countries. Some European countries decided to terminate nuclear power generation and to switch to sustainable energy production. Also the CO2 problem gives rise to new approaches for energy production and in all strategies the efficiency of utilization of electrical energy plays an important role. For the public acceptance of particle accelerator projects it is thus very important to optimize them for best utilization of electrical energy and to show these efforts to funding bodies and to the public. Within the European accelerator development program Eucard-2 [1] we organise a network EnEfficient [2] that aims at improving the energy efficiency of accelerators. In this paper we give some background information on the political situation, we describe the power flow in accelerator facilities and we give examples for developments of efficient accelerator systems, such as magnets, RF generation, heat recovery and energy management.
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| 9. |
- Stadlmann, J., et al.
(författare)
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Energy Effciency of Particle Accelerators: A Networking Effort within the EuCard2 Program
- 2014
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Ingår i: Proceedings of IPAC2014, Dresden, Germany. - 9783954501328
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Konferensbidrag (refereegranskat)abstract
- EuCARD2 is an Integrating Activity Project for coordinated Research and Development on Particle Accelerators, co-funded by the European Commission under the FP7 Capacities Programme. Within the network EnEfficient we address topics around energy efficiency of research accelerators. The ambitious scientific research goals of modern accelerator facilities lead to high requirements in beam power and beam quality for those research accelerators. In conjunction with the users' needs the power consumption and environmental impact of the research facilities becomes a major factor in the perception of both funding agencies and the general public. In this network we combine and focus the R&D done individually at different research centers into a series of workshops. We cover the topics “Energy recovery from cooling circuits“, “Higher electronic efficiency RF power generation“, “Short term energy storage systems”, “Virtual power plants” and “Beam transfer channels with low power consumption”. Our network activities are naturally open to external participants. With this work we will introduce our energy efficiency topics to interested participants and contributors from the whole community.
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