| 1. |
- Jung, Christian, et al.
(författare)
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A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention
- 2019
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Ingår i: Journal of critical care. - : W B SAUNDERS CO-ELSEVIER INC. - 0883-9441 .- 1557-8615. ; 52, s. 141-148
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to evaluate differences in outcome between patients admitted to intensive care unit (ICU) after elective versus acute surgery in a multinational cohort of very old patients (80 years; VIP). Predictors of mortality, with special emphasis on frailty, were assessed.Methods: In total, 5063 VIPs were induded in this analysis, 922 were admitted after elective surgery or intervention, 4141 acutely, with 402 after acute surgery. Differences were calculated using Mann-Whitney-U test and Wilcoxon test. Univariate and multivariable logistic regression were used to assess associations with mortality.Results: Compared patients admitted after acute surgery, patients admitted after elective surgery suffered less often from frailty as defined as CFS (28% vs 46%; p < 0.001), evidenced lower SOFA scores (4 +/- 5 vs 7 +/- 7; p < 0.001). Presence of frailty (CFS >4) was associated with significantly increased mortality both in elective surgery patients (7% vs 12%; p = 0.01), in acute surgery (7% vs 12%; p = 0.02).Conclusions: VIPs admitted to ICU after elective surgery evidenced favorable outcome over patients after acute surgery even after correction for relevant confounders. Frailty might be used to guide clinicians in risk stratification in both patients admitted after elective and acute surgery.
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| 2. |
- Allanach, Benjamin C., et al.
(författare)
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Simple and statistically sound strategies for analysing physical theories
- 2022
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Ingår i: Reports on progress in physics (Print). - : Institute of Physics Publishing (IOPP). - 0034-4885 .- 1361-6633. ; 85:5
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Forskningsöversikt (refereegranskat)abstract
- Physical theories that depend on many parameters or are tested against data from many different experiments pose unique challenges to statistical inference. Many models in particle physics, astrophysics and cosmology fall into one or both of these categories. These issues are often sidestepped with statistically unsound ad hoc methods, involving intersection of parameter intervals estimated by multiple experiments, and random or grid sampling of model parameters. Whilst these methods are easy to apply, they exhibit pathologies even in low-dimensional parameter spaces, and quickly become problematic to use and interpret in higher dimensions. In this article we give clear guidance for going beyond these procedures, suggesting where possible simple methods for performing statistically sound inference, and recommendations of readily-available software tools and standards that can assist in doing so. Our aim is to provide any physicists lacking comprehensive statistical training with recommendations for reaching correct scientific conclusions, with only a modest increase in analysis burden. Our examples can be reproduced with the code publicly available at Zenodo.
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| 3. |
- Bahl, Henning, et al.
(författare)
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Testing exotic scalars with HiggsBounds
- 2022
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 82:7
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Tidskriftsartikel (refereegranskat)abstract
- The program HiggsBounds is a well-established tool for testing Beyond-the-Standard Model (BSM) theories with an extended Higgs sector against experimental limits from collider searches at LEP, Tevatron and LHC. Thus far, it could be applied to any neutral or charged Higgs bosons originating from the modified Higgs sector. Implicitly, these particles were assumed to exhibit a somewhat hierarchical Yukawa structure as present in the Standard Model, where in particular the couplings to first generation fermions could be neglected. In this work, we extend the HiggsBounds functionalities to go beyond these restrictions, thus making the code applicable to any neutral or charged BSM scalars. Moreover, we develop a new approach to implement experimental searches whose kinematic acceptance depends significantly on the values of the involved couplings. We achieve this by recasting the searches to general scalar models. Using this approach we incorporate relevant current experimental limits from LHC searches for exotic scalars, and present the implications of these limits for a dark matter scalar mediator model, a flipped Two-Higgs-Doublet Model and a supersymmetric model with R-parity violation.
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| 4. |
- Bahl, Henning, et al.
(författare)
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The forgotten channels : charged Higgs boson decays to a W ± and a non-SM-like Higgs boson
- 2021
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2021:6
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Tidskriftsartikel (refereegranskat)abstract
- The presence of charged Higgs bosons is a generic prediction of multiplet extensions of the Standard Model (SM) Higgs sector. Focusing on the Two-Higgs-Doublet-Model (2HDM) with type I and lepton-specific Yukawa sectors, we discuss the charged Higgs boson collider phenomenology in the theoretically and experimentally viable parameter space. While almost all existing experimental searches at the LHC target the fermionic decays of charged Higgs bosons, we point out that the bosonic decay channels — especially the decay into a non-SM-like Higgs boson and a W boson — often dominate over the fermionic channels. Moreover, we revisit two genuine BSM effects on the properties of the discovered Higgs boson — the charged Higgs contribution to the diphoton rate and the Higgs decay to two light Higgs bosons — and their implication for the charged Higgs boson phenomenology. As main result of the present paper, we propose five two-dimensional benchmark scenarios with distinct phenomenological features in order to facilitate the design of dedicated LHC searches for charged Higgs bosons decaying into a W boson and a light, non-SM-like Higgs boson.
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| 5. |
- Bechtle, Philip, et al.
(författare)
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Applying exclusion likelihoods from LHC searches to extended Higgs sectors
- 2015
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:9
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Tidskriftsartikel (refereegranskat)abstract
- LHC searches for non-standard Higgs bosons decaying into tau lepton pairs constitute a sensitive experimental probe for physics beyond the Standard Model (BSM), such as supersymmetry (SUSY). Recently, the limits obtained from these searches have been presented by the CMS collaboration in a nearly model-independent fashion - as a narrow resonance model - based on the full 8 TeV dataset. In addition to publishing a 95 % C.L. exclusion limit, the full likelihood information for the narrow resonance model has been released. This provides valuable information that can be incorporated into global BSM fits. We present a simple algorithm that maps an arbitrary model with multiple neutral Higgs bosons onto the narrow resonance model and derives the corresponding value for the exclusion likelihood from the CMS search. This procedure has been implemented into the public computer code HiggsBounds (version 4.2.0 and higher). We validate our implementation by cross-checking against the official CMS exclusion contours in three Higgs benchmark scenarios in the Minimal Supersymmetric Standard Model (MSSM), and find very good agreement. Going beyond validation, we discuss the combined constraints of the tau tau search and the rate measurements of the SM-like Higgs at 125 GeV in a recently proposed MSSM benchmark scenario, where the lightest Higgs boson obtains SM-like couplings independently of the decoupling of the heavier Higgs states. Technical details for how to access the likelihood information within HiggsBounds are given in the appendix. The program is available at http://higgsbounds.hepforge.org.
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| 6. |
- Bechtle, Philip, et al.
(författare)
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HiggsBounds-4 : improved tests of extended Higgs sectors against exclusion bounds from LEP, the Tevatron and the LHC
- 2014
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 74:3
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Tidskriftsartikel (refereegranskat)abstract
- We describe the new developments in version 4 of the public computer code HiggsBounds. HiggsBounds is a tool to test models with arbitrary Higgs sectors, containing both neutral and charged Higgs bosons, against the published exclusion bounds from Higgs searches at the LEP, Tevatron and LHC experiments. From the model predictions for the Higgs masses, branching ratios, production cross sections and total decay widths-which are specified by the user in the input for the program-the code calculates the predicted signal rates for the search channels considered in the experimental data. The signal rates are compared to the expected and observed cross section limits from the Higgs searches to determine whether a point in the model parameter space is excluded at 95 % confidence level. In this paper we present a modification of the HiggsBounds main algorithm that extends the exclusion test in order to ensure that it provides useful results in the presence of one or more significant excesses in the data, corresponding to potential Higgs signals. We also describe a new method to test whether the limits from an experimental search performed under certain model assumptions can be applied to a different theoretical model. Further developments discussed here include a framework to take into account theoretical uncertainties on the Higgs mass predictions, and the possibility to obtain the likelihood of Higgs exclusion limits from LEP. Extensions to the user subroutines from earlier versions of HiggsBounds are described. The new features are demonstrated by additional example programs.
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| 7. |
- Bechtle, Philip, et al.
(författare)
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HiggsBounds-5 : testing Higgs sectors in the LHC 13 TeV Era
- 2020
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 80:12
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Tidskriftsartikel (refereegranskat)abstract
- We describe recent developments of the public computer code HiggsBounds. In particular, these include the incorporation of LHC Higgs search results from Run 2 at a center-of-mass energy of 13 TeV, and an updated and extended framework for the theoretical input that accounts for improved Higgs cross section and branching ratio predictions and new search channels. We furthermore discuss an improved method used in HiggsBounds to approximately reconstruct the exclusion likelihood for LHC searches for non-standard Higgs bosons decaying to ττ final states. We describe in detail the new and updated functionalities of the new version HiggsBounds-5.
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| 8. |
- Bechtle, Philip, et al.
(författare)
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HiggsSignals : Confronting arbitrary Higgs sectors with measurements at the Tevatron and the LHC
- 2014
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 74:2, s. 2711-
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Tidskriftsartikel (refereegranskat)abstract
- HiggsSignals is a Fortran90 computer code that allows to test the compatibility of Higgs sector predictions against Higgs rates and masses measured at the LHC or the Tevatron. Arbitrary models with any number of Higgs bosons can be investigated using a model-independent input scheme based on HiggsBounds. The test is based on the calculation of a measure from the predictions and the measured Higgs rates and masses, with the ability of fully taking into account systematics and correlations for the signal rate predictions, luminosity and Higgs mass predictions. It features two complementary methods for the test. First, the peak-centered method, in which each observable is defined by a Higgs signal rate measured at a specific hypothetical Higgs mass, corresponding to a tentative Higgs signal. Second, the mass-centered method, where the test is evaluated by comparing the signal rate measurement to the theory prediction at the Higgs mass predicted by the model. The program allows for the simultaneous use of both methods, which is useful in testing models with multiple Higgs bosons. The code automatically combines the signal rates of multiple Higgs bosons if their signals cannot be resolved by the experimental analysis. We compare results obtained with HiggsSignals to official ATLAS and CMS results for various examples of Higgs property determinations and find very good agreement. A few examples of HiggsSignals applications are provided, going beyond the scenarios investigated by the LHC collaborations. For models with more than one Higgs boson we recommend to use HiggsSignals and HiggsBounds in parallel to exploit the full constraining power of Higgs search exclusion limits and the measurements of the signal seen at GeV.
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| 9. |
- Bechtle, Philip, et al.
(författare)
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HiggsSignals-2 : probing new physics with precision Higgs measurements in the LHC 13 TeV era
- 2021
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 81:2
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Tidskriftsartikel (refereegranskat)abstract
- The program HiggsSignals confronts the predictions of models with arbitrary Higgs sectors with the available Higgs signal rate and mass measurements, resulting in a likelihood estimate. A new version of the program, HiggsSignals-2, is presented that contains various improvements in its functionality and applicability. In particular, the new features comprise improvements in the theoretical input framework and the handling of possible complexities of beyond-the-SM Higgs sectors, as well as the incorporation of experimental results in the form of simplified template cross section (STXS) measurements. The new functionalities are explained, and a thorough discussion of the possible statistical interpretations of the HiggsSignals results is provided. The performance of HiggsSignals is illustrated for some example analyses. In this context the importance of public information on certain experimental details like efficiencies and uncertainty correlations is pointed out. HiggsSignals is continuously updated to the latest experimental results and can be obtained at https://gitlab.com/higgsbounds/higgssignals.
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| 10. |
- Bechtle, Philip, et al.
(författare)
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Killing the cMSSM softly
- 2016
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 76:2, s. 1-22
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the constrained Minimal Supersymmetric Standard Model (cMSSM) in the light of constraining experimental and observational data from precision measurements, astrophysics, direct supersymmetry searches at the LHC and measurements of the properties of the Higgs boson, by means of a global fit using the program Fittino. As in previous studies, we find rather poor agreement of the best fit point with the global data. We also investigate the stability of the electro-weak vacuum in the preferred region of parameter space around the best fit point. We find that the vacuum is metastable, with a lifetime significantly longer than the age of the Universe. For the first time in a global fit of supersymmetry, we employ a consistent methodology to evaluate the goodness-of-fit of the cMSSM in a frequentist approach by deriving p values from large sets of toy experiments. We analyse analytically and quantitatively the impact of the choice of the observable set on the p value, and in particular its dilution when confronting the model with a large number of barely constraining measurements. Finally, for the preferred sets of observables, we obtain p values for the cMSSM below 10 %, i.e. we exclude the cMSSM as a model at the 90 % confidence level.
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