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- Fredell, L, et al.
(författare)
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Complex segregation analysis of hypospadias
- 2002
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Ingår i: Human genetics. - : Springer Science and Business Media LLC. - 0340-6717 .- 1432-1203. ; 3, s. 231-
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Fredell, L, et al.
(författare)
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Heredity of hypospadias and the significance of low birth weight
- 2002
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Ingår i: Journal of Urology. - 1527-3792 .- 0022-5347. ; 3, s. 1423-
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: We analyzed a large group of patients with hypospadias regarding familial aggregation, phenotype, twin rate and ethnic origin and assessed the correlation of low birth weight with hypospadias. Materials and Methods: We mailed questionnaires to 2,503 boys operated on for hypospadias in Sweden asking for additional cases of hypospadias in the family, the number of brothers in the nuclear family, and birth weight of the boys with hypospadias and their brothers. Results: Of the boys 7% reported 1 or more additional family members with hypospadias. The birth weight of the boys with hypospadias was significantly lower (p = 5 X 10(-13)) than the birth weight of their unaffected brothers. Phenotyping of 676 individuals revealed glandular hypospadias in 53%, penile forms in 39%, penoscrotal or perineal variants in 6% and cleaved prepuce as the only manifestation in 2%. There were 50% more twins than expected compared to the general population and established zygosity in 83% (67% monozygotic, 33% dizygotic). Non-Swedish ethnicity was noted in 22% of the subjects, a third of whom were from Middle Eastern countries. Conclusions: We present data on heredity, birth weight, phenotype and ethnic origin in a large group of patients with hypospadias. The finding of additional members with hypospadias in 7% of the families supports the concept that genetic factors are involved in the pathogenesis. The strong association with low birth weight may be explained by genetic and environmental factors.
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- Behar, Etienne, et al.
(författare)
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The root of a comet tail : Rosetta ion observations at comet 67P/Churyumov–Gerasimenko
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 616
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Tidskriftsartikel (refereegranskat)abstract
- Context.The first 1000 km of the ion tail of comet 67P/Churyumov–Gerasimenko were explored by the EuropeanRosettaspacecraft,2.7 au away from the Sun.Aims.We characterised the dynamics of both the solar wind and the cometary ions on the night-side of the comet’s atmosphere.Methods.We analysed in situ ion and magnetic field measurements and compared the data to a semi-analytical model.Results.The cometary ions are observed flowing close to radially away from the nucleus during the entire excursion. The solar windis deflected by its interaction with the new-born cometary ions. Two concentric regions appear, an inner region dominated by theexpanding cometary ions and an outer region dominated by the solar wind particles.Conclusions.The single night-side excursion operated byRosettarevealed that the near radial flow of the cometary ions can beexplained by the combined action of three different electric field components, resulting from the ion motion, the electron pressuregradients, and the magnetic field draping. The observed solar wind deflection is governed mostly by the motional electric field−uion×B.
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- Edberg, Niklas J. T., et al.
(författare)
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Atmospheric erosion of Venus during stormy space weather
- 2011
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 116, s. A09308-
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Tidskriftsartikel (refereegranskat)abstract
- We study atmospheric escape from Venus during solar minimum conditions when 147 corotating interaction regions (CIRs) and interplanetary coronal mass ejections (ICMEs) combined impact on the planet. This is the largest study to date of the effects of stormy space weather on Venus and we show for the first time statistically that the atmosphere of Venus is significantly affected by CIRs and ICMEs. When such events impact on Venus, as observed by the ACE and Venus Express satellites, the escape rate of Venus's ionosphere is measured to increase by a factor of 1.9, on average, compared to quiet solar wind times. However, the increase in escape flux during impacts can occasionally be significantly larger by orders of magnitude. Taking into account the occurrence rate of such events we find that roughly half (51%) of the outflow occurs during stormy space weather. Furthermore, we particularly discuss the importance of the increased solar wind dynamic pressure as well as the polarity change of the interplanetary magnetic field (IMF) in terms of causing the increase escape rate. The IMF polarity change across a CIR/ICME could cause dayside magnetic reconnection processes to occur in the induced magnetosphere of Venus, which would add to the erosion through associated particle acceleration.
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- Edberg, Niklas J. T., et al.
(författare)
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CME impact on comet 67P/Churyumov-Gerasimenko
- 2016
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 462, s. S45-S56
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Tidskriftsartikel (refereegranskat)abstract
- We present Rosetta observations from comet 67P/Churyumov-Gerasimenko during the impact of a coronal mass ejection (CME). The CME impacted on 2015 Oct 5-6, when Rosetta was about 800 km from the comet nucleus, and 1.4 au from the Sun. Upon impact, the plasma environment is compressed to the level that solar wind ions, not seen a few days earlier when at 1500 km, now reach Rosetta. In response to the compression, the flux of suprathermal electrons increases by a factor of 5-10 and the background magnetic field strength increases by a factor of similar to 2.5. The plasma density increases by a factor of 10 and reaches 600 cm(-3), due to increased particle impact ionization, charge exchange and the adiabatic compression of the plasma environment. We also observe unprecedentedly large magnetic field spikes at 800 km, reaching above 200 nT, which are interpreted as magnetic flux ropes. We suggest that these could possibly be formed by magnetic reconnection processes in the coma as the magnetic field across the CME changes polarity, or as a consequence of strong shears causing Kelvin-Helmholtz instabilities in the plasma flow. Due to the limited orbit of Rosetta, we are not able to observe if a tail disconnection occurs during the CME impact, which could be expected based on previous remote observations of other CME-comet interactions.
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- Mozzachiodi, S., et al.
(författare)
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Aborting meiosis allows recombination in sterile diploid yeast hybrids
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Hybrids are often considered evolutionary dead ends because they do not generate viable offspring. Here, the authors show that sterile yeast hybrids generate genetic diversity through meiotic-like recombination by aborting meiosis and return to asexual growth. Hybrids between diverged lineages contain novel genetic combinations but an impaired meiosis often makes them evolutionary dead ends. Here, we explore to what extent an aborted meiosis followed by a return-to-growth (RTG) promotes recombination across a panel of 20 Saccharomyces cerevisiae and S. paradoxus diploid hybrids with different genomic structures and levels of sterility. Genome analyses of 275 clones reveal that RTG promotes recombination and generates extensive regions of loss-of-heterozygosity in sterile hybrids with either a defective meiosis or a heavily rearranged karyotype, whereas RTG recombination is reduced by high sequence divergence between parental subgenomes. The RTG recombination preferentially arises in regions with low local heterozygosity and near meiotic recombination hotspots. The loss-of-heterozygosity has a profound impact on sexual and asexual fitness, and enables genetic mapping of phenotypic differences in sterile lineages where linkage analysis would fail. We propose that RTG gives sterile yeast hybrids access to a natural route for genome recombination and adaptation.
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