| 1. |
- Rolf, Julia, 1979, et al.
(författare)
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Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets.
- 2008
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Ingår i: Molecular immunology. - : Elsevier BV. - 0161-5890 .- 1872-9142. ; 45:9, s. 2607-20
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Tidskriftsartikel (refereegranskat)abstract
- CD1d-restricted natural killer T (NKT) cells can have multiple effects on an immune response, including the activation, regulation and attraction of innate immune cells, and modulation of adaptive immunity. Recent studies reveal that there are distinct subsets of NKT cells which selectively perform some of the functions attributed to CD1d-restricted cells, but the mechanisms underlying these functional differences have not been resolved. Our aim in this study was to identify novel NKT cell associated traits that would provide important insight into NKT cell activation and function. To this end, we have performed gene expression profiling of two separate subsets of NKT cells, analyzing genes differentially expressed in these cells compared to conventional CD4(+)NK1.1(-) T cells. We identify different sets of genes over expressed in each of the two NKT cell types, as well as genes that are common to the two CD1d-restricted NKT cell populations analyzed. A large number of these genes are highly relevant for NKT cell development, activation and function. Each NKT subtype displayed a unique set of chemokine receptors, integrins and molecules related to effector function, supporting the notion that distinct NKT cells can be selectively engaged and have diverse functions in different types of immune reactions.
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| 2. |
- Andersson, Christina, et al.
(författare)
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Cultivating Compassion and Reducing Stress and Mental Ill-Health in Employees : A Randomized Controlled Study
- 2022
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Stress and mental ill-health carry considerable costs for both individuals and organizations. Although interventions targeting compassion and self-compassion have been shown to reduce stress and benefit mental health, related research in organizational settings is limited. We investigated the effects of a 6-week psychological intervention utilizing compassion training on stress, mental health, and self-compassion. Forty-nine employees of two organizations were randomly assigned to either the intervention (n = 25) or a physical exercise control condition (n = 24). Multilevel growth models showed that stress (p = 0.04) and mental ill-health (p = 0.02) decreased over 3 months in both groups (pre-intervention to follow-up: Cohen’s d = −0.46 and d = 0.33, respectively), while self-compassion only increased in the intervention group (p = 0.03, between group d = 0.53). There were no significant effects on life satisfaction in any of the groups (p > 0.53). The findings show promising results regarding the ability of compassion training within organizations to decrease stress and mental ill-health and increase self-compassion.
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| 3. |
- Birnbaum, Daniel, et al.
(författare)
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Thirteen questions about the object to Graham Harman
- 2020
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Ingår i: Artful objects : Graham Harman on art and the business of speculative realism. - Berlin ; Stockholm : Sternberg Press ; Stockholm School of Economics. - 9783956795244 ; , s. 43-72
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Bäcklander, Gisela, 1983-, et al.
(författare)
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Navigating the Activity Based Working Environment – Relationships of Self-Leadership, Autonomy and Information Richness with Cognitive Stress and Performance
- 2019
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Ingår i: Scandinavian Journal of Work and Organizational Psychology. - Stockholm : Stockholm University Press. - 2002-2867.
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Tidskriftsartikel (refereegranskat)abstract
- In Activity Based Working Environment (ABWE) offices, employees are allowed increased autonomy and are expected to choose where, when, with whom, and to some degree with what, to work; in other words, employees are expected to self-lead to a higher degree and to coordinate and align with colleagues. Effects of these expectations on employees’ cognitive stress and performance are understudied. In the present study, Swedish ABWE workers (N = 416) are compared with workers in cell offices (N = 30) and landscape offices (N = 64), and relationships of self-leadership, information richness, and autonomy with cognitive stress and performance were examined using regression analysis. Results show no relationship between office type and outcomes. For cognitive stress, information richness had the largest negative relationship, followed by self-leadership: goal-setting and autonomy. For performance, self-leadership: goal-setting had the largest positive relationship, followed by information richness. This suggests that when organizational situations cannot be strongly structured – for example because the best work process is not known, or innovation or different collaboration constellations are needed – they need instead to be enriched so that employee orientation and coordination do not become too much of a burden on the individual employee, disrupting cognitive functioning and performance.
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| 5. |
- Ericsson, Daniel, 1967-, et al.
(författare)
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Body, mind, and soul principles for designing management education : an ethnography from the future
- 2022
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Ingår i: Culture and Organization. - : Taylor & Francis. - 1475-9551 .- 1477-2760. ; 28:3-4, s. 313-329
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we advance the conversation about management education by outlining a future scenario of management teaching in which art is employed as a method, learning goal, and methodology. The scenario is informed by our personal experiences of teaching management and art expressed in terms of three design principles for management education: the principles of body, mind, and soul; and it is presented as an ethnography from the future. This future is envisioned to be characterized by four assumptions: that students are co-creators of knowledge; that the role of teachers is to facilitate the students’ learning processes; that Artificial Intelligence is an integral part of learning processes; and that the primary learning objective for the students is to develop their relations to the world and contribute with feasible future solutions to wicked problems and global challenges.
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| 6. |
- Fransson, Emma, et al.
(författare)
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Diagnostic Efficacy of Rectal Suction Biopsy with Regard to Weight in Children Investigated for Hirschsprung's Disease
- 2022
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Ingår i: Children. - : MDPI AG. - 2227-9067. ; 9:2, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND/AIM: Diagnostic efficacy, defined as the percentage of rectal suction biopsy (RSB) specimens sufficient enough to determine the absence of ganglia cells in Hirschsprung's disease (HD) diagnosis, has been reported to be low, requiring repeated biopsies. The aim was to explore whether RSB diagnostic efficacy was influenced by the child's weight and to ascertain whether RSB efficacy differed between aganglionic and ganglionic tissue.MATERIALS AND METHODS: Efficacy analyses were conducted in a national HD-center's register on children 0-15 kg, examined between 2011-2019. First-time RSB diagnostic efficacy was correlated to the children's weight and final HD diagnosis.RESULTS: Among the 84 children who had first-time RSB, the overall diagnostic efficacy was 85% (71/84). The efficacy was higher among children weighing less than the identified cut-off of 9.0 kg (89% in 0-9.0 kg versus 62% in 9.01-15.0 kg, p = 0.026). Among children diagnosed with HD, 96% (26/27) weighed 0-9.0 kg. In this weight group, the diagnostic efficacy was lower in aganglionosis compared to ganglionosis (77%; 20/26 versus 96%; 43/45), p = 0.045).CONCLUSIONS: The RSB diagnostic efficacy was significantly higher in children weighing less than 9.0 kg and was less in aganglionic compared to ganglionic tissue. Therefore, weight can be useful to predict RSB diagnostic efficacy.
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| 7. |
- Fransson, Emma, et al.
(författare)
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Systematic orientation of fresh rectal suction biopsies improves histopathological diagnostics in hirschsprung’s disease – a method description and preliminary report
- 2023
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Ingår i: BMC Pediatrics. - 1471-2431. ; 23
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Tidskriftsartikel (refereegranskat)abstract
- Background: Optimizing rectal suction biopsy (RSB) diagnostics in Hirschsprung’s disease (HD) may shorten diagnostic time and prevent need for repeated biopsies. Aim: To explore whether systematic orientation of fresh RSB specimens increased biopsy quality, diagnostic times, diagnostic efficacy, and histopathologic workload, and to explore these outcome measures for aganglionic specimens. Materials/Methods: This was an observational case-control study conducted at a national referral center for HD on data collected from the local HD-diagnostic register. From 2019 each fresh RSB was oriented by the collector in a notch in a foam cushion, placed in a separate cassette, and sent in formalin for pathological analysis. Outcome measures of oriented RSB samples collected 2019–2021 were compared to those of non-oriented RSB samples collected 2015–2018. Staining/immunohistochemistry consisted of hematoxylin eosin, S-100 and calretinin. Results: 78 children with 81 RSBs and 242 biopsy analyzes were included. The frequency of high-quality RSB specimens was higher in oriented: 40% (42/106) versus non-oriented 25% (34/136) (p = 0.018), the diagnostic turnaround time was shorter: 2 days (1–5) versus 3 days (2–8) (p = 0.015), and the number of additional sectioning/leveling/re-orientation per biopsy was lower: 7 (3–26) versus 16 (7–72) (p = 0.011). Specifically for aganglionic specimens, the frequency of high-quality biopsies was generally higher in oriented than in non-oriented RSB specimens: 47% (28/59) versus 14% (7/50) (p < 0.001); the diagnostic efficacy was higher 95% (19/20) versus 60% (9/15) (p = 0.027) and the diagnostic turnaround time shorter: 2 days (2–3) versus 3 days (2–8) (p = 0.036). Conclusions: Systematic orientation of fresh RSB specimens improves HD diagnostics. Improvement was consistent in aganglionic specimens.
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| 8. |
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| 9. |
- Köping, Ann-Sofie, et al.
(författare)
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Kulturens ekonomisering
- 2008
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Ingår i: KulturSverige 2009. - Linköping : Swedish Cultural Policy Research Observatory. - 9789173937504 ; , s. 85-89
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Den här artikeln handlar om kulturens ekonomisering på samhälls-, organisations- respektive individnivå. Vi konstaterar bland annat att det på alla tre nivåerna sker en förskjutning mot en marknadsdiskurs och att den kommersiella logiken får allt större svängrum på bekostnad av den kulturella, vilket vi kan ställa oss skeptiska till. Trots – eller på grund av – att vi själva är ekonomer.
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| 10. |
- Levin, Sofia, et al.
(författare)
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Kreativitet och kapital på arkitektkontoret
- 2013
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Ingår i: Kreativt kapital: ledning och organisering i kulturella och kreativa näringar. - Stockholm : 8tto. - 9789187419065
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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