| 1. |
- Marto, João Pedro, et al.
(författare)
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Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry.
- 2023
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Ingår i: Neurology. - 1526-632X. ; 100:7
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Tidskriftsartikel (refereegranskat)abstract
- COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT).Of a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour mortality (OR 2.47; 95% CI 1.58-3.86), and 3-month mortality (OR 1.88; 95% CI 1.52-2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60).Patients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis.The study was registered under ClinicalTrials.gov identifier NCT04895462.
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| 2. |
- Greifzu, Moritz, et al.
(författare)
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Laser Treatment as Sintering Process for Dispenser Printed Bismuth Telluride Based Paste
- 2019
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Ingår i: Materials. - : MDPI. - 1996-1944. ; 12:20
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Tidskriftsartikel (refereegranskat)abstract
- Laser sintering as a thermal post treatment method for dispenser printed p- and n-type bismuth telluride based thermoelectric paste materials was investigated. A high-power fiber laser (600 W, 1064 nm) was used in combination with a scanning system to achieve high processing speed. A Design of Experiment (DoE) approach was used to identify the most relevant processing parameters. Printed layers were laser treated with different process parameters and the achieved sheet resistance, electrical conductivity, and Seebeck coefficient are compared to tube furnace processed reference specimen. For p-type material, electrical conductivity of 22 S/cm was achieved, compared to 15 S/cm in tube furnace process. For n-type material, conductivity achieved by laser process was much lower (7 S/cm) compared to 88 S/cm in furnace process. Also, Seebeck coefficient decreases during laser processing (40–70 µV/K and −110 µV/K) compared to the oven process (251 µV/K and −142 µV/K) for p- and n-type material. DoE did not yet deliver a set of optimum processing parameters, but supports doubts about the applicability of area specific laser energy density as a single parameter to optimize laser sintering process.
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| 3. |
- Gruber, Samira, et al.
(författare)
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Physical and Geometrical Properties of Additively Manufactured Pure Copper Samples Using a Green Laser Source
- 2021
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Ingår i: Materials. - : MDPI. - 1996-1944. ; 14:13
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Tidskriftsartikel (refereegranskat)abstract
- So far, copper has been difficult to process via laser powder bed fusion due to low absorption with the frequently used laser systems in the infrared wavelength range. However, green laser systems have emerged recently and offer new opportunities in processing highly reflective materials like pure copper through higher absorptivity. In this study, pure copper powders from two suppliers were tested using the same machine parameter sets to investigate the influence of the powder properties on the material properties such as density, microstructure, and electrical conductivity. Samples of different wall thicknesses were investigated with the eddy-current method to analyze the influence of the sample thickness and surface quality on the measured electrical conductivity. The mechanical properties in three building directions were investigated and the geometrical accuracy of selected geometrical features was analyzed using a benchmark geometry. It could be shown that the generated parts have a relative density of above 99.95% and an electrical conductivity as high as 100% International Annealed Copper Standard (IACS) for both powders could be achieved. Furthermore, the negative influence of a rough surface on the measured eddy-current method was confirmed.
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| 4. |
- Gruber, Samira, et al.
(författare)
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Process development for laser powder bed fusion of GRCop-42 using a 515 nm laser source
- 2023
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Ingår i: Journal of laser applications. - : Laser Institute of America. - 1042-346X .- 1938-1387. ; 35:4
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Tidskriftsartikel (refereegranskat)abstract
- Copper is widely used in high heat flux and electrical applications because of its excellent electrical and thermal conductivity properties. Alloying elements such as chromium or nickel are added to strengthen the material, especially for higher temperatures. Cu4Cr2Nb, also known as GRCop-42, is a dispersion-strengthened copper-chromium-niobium alloy developed by NASA for high-temperature applications with high thermal and mechanical stresses such as rocket engines. Additive manufacturing (AM) enables applications with complex functionalized geometries and is particularly promising in the aerospace industry. In this contribution, a parametric study was performed for GRCop-42 and the AM process laser powder bed fusion (PBF-LB/M) using a green laser source for two-layer thicknesses of 30 and 60 µm. Density, electrical conductivity, hardness, microstructure, and static mechanical properties were analyzed. Various heat treatments ranging from 400 to 1000 °C and 30 min to 4 h were tested to increase the electrical conductivity and hardness. For both layer thicknesses, dense parameter sets could be obtained with resulting relative densities above 99.8%. Hardness and electrical conductivity could be tailored in the range of 103-219 HV2 and 24%-88% International Annealed Copper Standard (IACS) depending on the heat treatment. The highest ultimate tensile strength (UTS) obtained was 493 MPa. An aging temperature of 700 °C for 30 min showed the best combination of room temperature properties such as electrical conductivity of 83.76%IACS, UTS of 481 MPa, elongation at break (A) at 24%, and hardness of 125 HV2.
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| 5. |
- Hendl, Julius, et al.
(författare)
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In Situ CT Tensile Testing of an Additively Manufactured and Heat-Treated Metastable ß-Titanium Alloy (Ti-5Al-5Mo-5V-3Cr)
- 2021
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Ingår i: Applied Sciences. - : MDPI. - 2076-3417. ; 11:21
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Tidskriftsartikel (refereegranskat)abstract
- Additive manufacturing has been considered a suitable process for developing high-performance parts of medical or aerospace industries. The electron beam powder bed fusion process, EB-PBF, is a powder bed fusion process carried out in a vacuum, in which the parts are melted using a highly focused electron beam. The material class of metastable β-titanium alloys, and especially Ti-5Al-5Mo-5V-3Cr, show great potential for use as small and highly complex load-bearing parts. Specimens were additively manufactured with optimised process parameters and different heat treatments used in order to create tailored mechanical properties. These heat-treated specimens were analysed with regard to their microstructure (SEM) and their mechanical strength (tensile testing). Furthermore, in situ tensile tests, using a Deben CT5000 and a YXLON ff35 industrial µ-CT, were performed and failure-critical defects were detected, analysed and monitored. Experimental results indicate that, if EB-PBF-manufactured Ti-5553 is heat-treated differently, a variety of mechanical properties are possible. Regarding their fracture mechanisms, failure-critical defects can be detected at different stages of the tensile test and defect growth behaviour can be analysed.
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| 6. |
- Huseinovic, Ena, et al.
(författare)
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Timing of eating across ten European countries : results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study
- 2019
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Ingår i: Public Health Nutrition. - : Nutrition Society. - 1368-9800 .- 1475-2727. ; 22:2, s. 324-335
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To examine timing of eating across ten European countries.DESIGN: Cross-sectional analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study using standardized 24 h diet recalls collected during 1995-2000. Eleven predefined food consumption occasions were assessed during the recall interview. We present time of consumption of meals and snacks as well as the later:earlier energy intake ratio, with earlier and later intakes defined as 06.00-14.00 and 15.00-24.00 hours, respectively. Type III tests were used to examine associations of sociodemographic, lifestyle and health variables with timing of energy intake.SETTING: Ten Western European countries.SUBJECTS: In total, 22 985 women and 13 035 men aged 35-74 years (n 36 020).RESULTS: A south-north gradient was observed for timing of eating, with later consumption of meals and snacks in Mediterranean countries compared with Central and Northern European countries. However, the energy load was reversed, with the later:earlier energy intake ratio ranging from 0·68 (France) to 1·39 (Norway) among women, and from 0·71 (Greece) to 1·35 (the Netherlands) among men. Among women, country, age, education, marital status, smoking, day of recall and season were all independently associated with timing of energy intake (all P<0·05). Among men, the corresponding variables were country, age, education, smoking, physical activity, BMI and day of recall (all P<0·05).CONCLUSIONS: We found pronounced differences in timing of eating across Europe, with later meal timetables but greater energy load earlier during the day in Mediterranean countries compared with Central and Northern European countries.
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| 7. |
- Moritz, Juliane, et al.
(författare)
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Additive Manufacturing of Titanium with Different Surface Structures for Adhesive Bonding and Thermal Direct Joining with Fiber-Reinforced Polyether-Ether-Ketone (PEEK) for Lightweight Design Applications
- 2021
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Ingår i: Metals. - : MDPI. - 2075-4701. ; 11:2
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Tidskriftsartikel (refereegranskat)abstract
- Hybrid joints consisting of metals and fiber-reinforced polymer composites exhibit highly desirable properties for many lightweight design applications. This study investigates the potential of additively manufactured surface structures for enhancing the bond strength of such joints in comparison to face milled and laser structured surfaces. Titanium samples with different surface structures (as-built surface, groove-, and pin-shaped structures) were manufactured via electron beam melting and joined to carbon fiber-reinforced polyether-ether-ketone (PEEK) via adhesive bonding and thermal direct joining, respectively. Bond strength was evaluated by tensile shear testing. Samples were exposed to salt spray testing for 1000 h for studying bond stability under harsh environmental conditions. The initial tensile shear strengths of the additively manufactured samples were competitive to or in some cases even exceeded the values achieved with laser surface structuring for both investigated joining methods. The most promising results were found for pin-shaped surface structures. However, the hybrid joints with additively manufactured structures tended to be more susceptible to degradation during salt spray exposure. It is concluded that additively manufactured structures can be a viable alternative to laser surface structuring for both adhesive bonding and thermal direct joining of metal-polymer hybrid joints, thus opening up new potentials in lightweight design.
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| 8. |
- Moritz, Juliane, et al.
(författare)
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Electron beam powder bed fusion of γ‐titanium aluminide : Effect of processing parameters on part density, surface characteristics and aluminum content
- 2021
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Ingår i: Metals. - : MDPI. - 2075-4701. ; 11:7
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Tidskriftsartikel (refereegranskat)abstract
- Gamma titanium aluminides are very interesting for their use in high‐performance applications such as aircraft engines due to their low density, high stiffness and favorable hightemperature properties. However, the pronounced brittleness of these intermetallic alloys is a major challenge for their processing through conventional fabrication methods. Additive manufacturing by means of electron beam powder bed fusion (EB‐PBF) significantly improves the processability of titanium aluminides due to the high preheating temperatures and facilitates complex components. The objective of this study was to determine a suitable processing window for EB‐PBF of the TNM‐B1 alloy (Ti‐43.5Al‐4Nb‐1Mo‐0.1B), using an increased aluminum content in the powder raw material to compensate for evaporation losses during the process. Design of experiments was used to evaluate the effect of beam current, scan speed, focus offset, line offset and layer thickness on porosity. Top surface roughness was assessed through laser scanning confocal microscopy. Scanning electron microscopy, electron backscatter diffraction (EBSD) and energydispersive X‐ray spectroscopy (EDX) were used for microstructural investigation and to analyze aluminum loss depending on the volumetric energy density used in EB‐PBF. An optimized process parameter set for achieving part densities of 99.9% and smooth top surfaces was derived. The results regarding microstructures and aluminum evaporation suggest a solidification via the β‐phase.
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| 9. |
- Moritz, Juliane, et al.
(författare)
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Influence of Electron Beam Powder Bed Fusion Process Parameters at Constant Volumetric Energy Density on Surface Topography and Microstructural Homogeneity of a Titanium Aluminide Alloy
- 2023
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Ingår i: Advanced Engineering Materials. - : John Wiley & Sons. - 1438-1656 .- 1527-2648. ; 25:15
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Tidskriftsartikel (refereegranskat)abstract
- In powder bed fusion additive manufacturing, the volumetric energy density E V is a commonly used parameter to quantify process energy input. However, recent results question the suitability of E V as a design parameter, as varying the contributing parameters may yield different part properties. Herein, beam current, scan velocity, and line offset in electron beam powder bed fusion (PBF-EB) of the titanium aluminide alloy TNM–B1 are systematically varied while maintaining an overall constant E V. The samples are evaluated regarding surface morphology, relative density, microstructure, hardness, and aluminum loss due to evaporation. Moreover, the specimens are subjected to two different heat treatments to obtain fully lamellar (FL) and nearly lamellar (NLγ) microstructures, respectively. With a combination of low beam currents, low-to-intermediate scan velocities, and low line offsets, parts with even surfaces, relative densities above 99.9%, and homogeneous microstructures are achieved. On the other hand, especially high beam currents promote the formation of surface bulges and pronounced aluminum evaporation, resulting in inhomogeneous banded microstructures after heat treatment. The results demonstrate the importance of considering the individual parameters instead of E V in process optimization for PBF-EB.
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| 10. |
- Moritz, Juliane, et al.
(författare)
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Influence of Two-Step Heat Treatments on Microstructure and Mechanical Properties of a β-Solidifying Titanium Aluminide Alloy Fabricated via Electron Beam Powder Bed Fusion
- 2023
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Ingår i: Advanced Engineering Materials. - : John Wiley & Sons. - 1438-1656 .- 1527-2648. ; 25:2
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Tidskriftsartikel (refereegranskat)abstract
- Additive manufacturing technologies, particularly electron beam powder bed fusion (PBF-EB/M), are becoming increasingly important for the processing of intermetallic titanium aluminides. This study presents the effects of hot isostatic pressing (HIP) and subsequent two-step heat treatments on the microstructure and mechanical properties of the TNM-B1 alloy (Ti–43.5Al–4Nb–1Mo–0.1B) fabricated via PBF-EB/M. Adequate solution heat treatment temperatures allow the adjustment of fully lamellar (FL) and nearly lamellar (NL-β) microstructures. The specimens are characterized by optical microscopy and scanning electron microscopy (SEM), X-ray computed tomography (CT), X-ray diffraction (XRD), and electron backscatter diffraction (EBSD). The mechanical properties at ambient temperatures are evaluated via tensile testing and subsequent fractography. While lack-of-fusion defects are the main causes of failure in the as-built condition, the mechanical properties in the heat-treated conditions are predominantly controlled by the microstructure. The highest ultimate tensile strength is achieved after HIP due to the elimination of lack-of-fusion defects. The results reveal challenges originating from the PBF-EB/M process, for example, local variations in chemical composition due to aluminum evaporation, which in turn affect the microstructures after heat treatment. For designing suitable heat treatment strategies, particular attention should therefore be paid to the microstructural characteristics associated with additive manufacturing.
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