| 1. |
- Agriesti, Serio Angelo Maria, et al.
(författare)
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Roadworks warning-closure of a lane, the Impact of C-ITS messages
- 2020
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Ingår i: Infrastructures. - : MDPI AG. - 2412-3811. ; 5:3
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Tidskriftsartikel (refereegranskat)abstract
- By now, it is widely acknowledged among stakeholders and academia that infrastructures will have to be composed both by a physical component and a digital one. The deployment of technologies exploiting dedicated short-range communications is viewed as the most cost-effective solution to face the foreseen growth of mobility. Still, little has been done to define the best implementation logic of DSRC. Aim of this paper is to frame the possible impacts arising by the implementation of a cooperative intelligent transport system (C-ITS)-use case: roadworks warning.closure of a lane, and, in order to achieve this result, microsimulations are exploited. The results are intended to support both road operators and car-makers in defining the best operational logics and the possible benefits achievable by presenting the cooperative message at a certain distance for certain market penetrations. Moreover, if the C-ITS message actually entails benefits or simply disrupts the upstream traffic should be assessed in advance, before implementing the system. The obtained results show that the risk of disruption and of reduction in traffic efficiency arises at lower market penetration levels. Nevertheless, a consistent trend in delay reduction is recorded upstream the roadworks, the highest reduction being equal to 8.66%. Moreover, the average speed at the roadworks entrance on the closing lane increases by a difference equal to around 10 km/h, while the average time in the queue at the highest market penetration reduces by 60 s on the open lane and 25 s on the closing one. These presented results reflect the way the traffic shifts from the slow to the fast lane thanks to the C-ITS system and effectively frames both the potentialities and the risks of the system.
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| 2. |
- Burri, Reto, et al.
(författare)
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Adaptive divergence of ancient gene duplicates in the avian MHC class II beta
- 2010
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Ingår i: Molecular biology and evolution. - : Oxford University Press (OUP). - 0737-4038 .- 1537-1719. ; 27:10, s. 2360-2374
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Tidskriftsartikel (refereegranskat)abstract
- Gene duplication and neofunctionalization are known to be important processes in the evolution of phenotypic complexity. They account for important evolutionary novelties that confer ecological adaptation, such as the major histocompatibility complex (MHC), a multigene family crucial to the vertebrate immune system. In birds, two MHC class II β (MHCIIβ) exon 3 lineages have been recently characterized, and two hypotheses for the evolutionary history of MHCIIβ lineages were proposed. These lineages could have arisen either by 1) an ancient duplication and subsequent divergence of one paralog or by 2) recent parallel duplications followed by functional convergence. Here, we compiled a data set consisting of 63 MHCIIβ exon 3 sequences from six avian orders to distinguish between these hypotheses and to understand the role of selection in the divergent evolution of the two avian MHCIIβ lineages. Based on phylogenetic reconstructions and simulations, we show that a unique duplication event preceding the major avian radiations gave rise to two ancestral MHCIIβ lineages that were each likely lost once later during avian evolution. Maximum likelihood estimation shows that following the ancestral duplication, positive selection drove a radical shift from basic to acidic amino acid composition of a protein domain facing the α-chain in the MHCII α β-heterodimer. Structural analyses of the MHCII α β-heterodimer highlight that three of these residues are potentially involved in direct interactions with the α-chain, suggesting that the shift following duplication may have been accompanied by coevolution of the interacting α- and β-chains. These results provide new insights into the long-term evolutionary relationships among avian MHC genes and open interesting perspectives for comparative and population genomic studies of avian MHC evolution.
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