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Träfflista för sökning "WFRF:(Stussi Georg) "

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1.	Condoluci, Adalgisa, et al. (författare) International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia 2020 Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 135:21, s. 1859-1869 Tidskriftsartikel (refereegranskat)abstract Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients with CLL with early, asymptomatic disease (International Prognostic Score for Early-stage CLL [IPS-E]). Individual patient data from 11 international cohorts of patients with early-stage CLL (n = 4933) were analyzed to build and validate the prognostic score. Three covariates were consistently and independently correlated with TTFT: unmutated immunoglobulin heavy variable gene (IGHV), absolute lymphocyte count higher than 15 x 10(9)/L, and presence of palpable lymph nodes. The IPS-E was the sum of the covariates (1 point each), and separated low-risk (score 0), intermediate-risk (score 1), and high-risk (score 2-3) patients showing a distinct TTFT. The score accuracy was validated in 9 cohorts staged by the Binet system and 1 cohort staged by the Rai system. The C-index was 0.74 in the training series and 0.70 in the aggregate of validation series. By meta-analysis of the training and validation cohorts, the 5-year cumulative risk for treatment start was 8.4%, 28.4%, and 61.2% among low-risk, intermediate-risk, and high-risk patients, respectively. The IPS-E is a simple and robust prognostic model that predicts the likelihood of treatment requirement in patients with early-stage CLL. The IPS-E can be useful in clinical management and in the design of early intervention clinical trials.
2.	Güngör, Tayfun, et al. (författare) Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study. 2014 Ingår i: Lancet. - 1474-547X. ; 383:9915, s. 436-448 Tidskriftsartikel (refereegranskat)abstract In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to enhance myeloid engraftment and reduce organ toxicity in these patients.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Stussi, Georg (2); Smedby, Karin E. (1); Ahmad, Imran (1); Rosenquist, Richard (1); Pospisilova, Sarka (1); Fasth, Anders, 1945 (1); visa fler...; Albert, Michael H (1); Fischer, Alain (1); Belohradsky, Bernd H (1); Hassan, Moustapha (1); Mattsson, Mattias (1); Ferrarini, Manlio (1); Stepensky, Polina (1); Neri, Antonino (1); Morabito, Fortunato (1); Cutrona, Giovanna (1); Kotaskova, Jana (1); Delgado, Julio (1); Doubek, Michael (1); Rossi, Davide (1); Gaidano, Gianluca (1); Montserrat, Emili (1); Doehner, Hartmut (1); Stilgenbauer, Stepha ... (1); Rabe, Kari G. (1); Wu, Wei (1); Rentsch, Katharina (1); Forconi, Francesco (1); Foa, Robin (1); Herling, Carmen D. (1); Bahlo, Jasmin (1); Hallek, Michael (1); Zucca, Emanuele (1); Condoluci, Adalgisa (1); di Bergamo, Lodovico ... (1); Langerbeins, Petra (1); Hoechstetter, Manuel ... (1); De Paoli, Lorenzo (1); Gentile, Massimo (1); Mauro, Francesca R. (1); Chiodin, Giorgia (1); Deambrogi, Clara (1); Spina, Valeria (1); Bruscaggin, Alessio (1); Moia, Riccardo (1); Bianchi, Elena (1); Gerber, Bernhard (1); Gillessen, Silke (1); Ghielmini, Michele (1); Cavalli, Franco (1); visa färre...

Lärosäte: Göteborgs universitet (1); Uppsala universitet (1); Karolinska Institutet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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