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Träfflista för sökning "WFRF:(Su PQ) "

Search: WFRF:(Su PQ)

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1.
  • Kou, I, et al. (author)
  • A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis
  • 2018
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 11575-
  • Journal article (peer-reviewed)abstract
    • Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. The locus is represented by rs6570507 located within GPR126. To ensure the association of rs6570507 with AIS, we conducted a meta-analysis using eight cohorts from East Asia, Northern Europe and USA. The analysis included a total of 6,873 cases and 38,916 controls and yielded significant association (combined P = 2.95 × 10−20; odds ratio = 1.22), providing convincing evidence of the worldwide association between rs6570507 and AIS susceptibility. In silico analyses strongly suggested that GPR126 is a susceptibility gene at this locus.
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2.
  • Ogura, Y, et al. (author)
  • An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis
  • 2018
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 4730-
  • Journal article (peer-reviewed)abstract
    • Adolescent idiopathic scoliosis (AIS) is a common spinal deformity with the prevalence of approximately 3%. We previously conducted a genome-wide association study (GWAS) using a Japanese cohort and identified a novel locus on chromosome 9p22.2. However, a replication study using multi-population cohorts has not been conducted. To confirm the association of 9p22.2 locus with AIS in multi-ethnic populations, we conducted international meta-analysis using eight cohorts. In total, we analyzed 8,756 cases and 27,822 controls. The analysis showed a convincing evidence of association between rs3904778 and AIS. Seven out of eight cohorts had significant P value, and remaining one cohort also had the same trend as the seven. The combined P was 3.28 × 10−18 (odds ratio = 1.19, 95% confidence interval = 1.14–1.24). In silico analyses suggested that BNC2 is the AIS susceptibility gene in this locus.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Takahashi, Y. (2)
Watanabe, K. (2)
Zhou, H. (2)
Einarsdottir, E (2)
Kere, J (2)
Wu, N. (2)
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Liu, G (2)
Gerdhem, P (2)
Qiu, Y. (2)
Ikegawa, S (2)
Wu, ZH (2)
Matsumoto, M. (2)
Takeda, K (2)
Huang, DS (2)
Grauers, A (2)
Kou, I. (2)
Zhang, L. (1)
Liu, H. (1)
Xu, Y. (1)
Wang, YP (1)
Tang, F. (1)
Lu, Y (1)
Chen, M (1)
Liu, YN (1)
Li, F. (1)
Li, C. (1)
Zhang, M (1)
Kubo, M (1)
Huang, YH (1)
Li, W. (1)
Li, P. (1)
Ouyang, WW (1)
Shi, W. (1)
Zhao, JH (1)
Mao, W. (1)
Bao, K (1)
Li, JM (1)
Momozawa, Y (1)
Yang, HT (1)
Yang, LH (1)
Sun, W (1)
Wen, ZH (1)
Chen, HY (1)
Fu, LZ (1)
Liu, XS (1)
Wu, YF (1)
Su, GB (1)
Peng, Y (1)
Li, HY (1)
Xu, P. (1)
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University
Karolinska Institutet (3)
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)

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