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- Hua, Kuo-Tai, et al.
(författare)
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N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity
- 2011
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Ingår i: Cancer Cell. - : Cell Press. - 1535-6108 .- 1878-3686. ; 19:2, s. 218-231
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Tidskriftsartikel (refereegranskat)abstract
- N-α-acetyltransferase 10 protein, Naa10p, is an N-acetyltransferase known to be involved in cell cycle control. We found that Naa10p was expressed lower in varieties of malignancies with lymph node metastasis compared with non-lymph node metastasis. Higher Naa10p expression correlates the survival of lung cancer patients. Naa10p significantly suppressed migration, tumor growth, and metastasis independent of its enzymatic activity. Instead, Naa10p binds to the GIT-binding domain of PIX, thereby preventing the formation of the GIT-PIX-Paxillin complex, resulting in reduced intrinsic Cdc42/Rac1 activity and decreased cell migration. Forced expression of PIX in Naa10-transfected tumor cells restored the migration and metastasis ability. We suggest that Naa10p functions as a tumor metastasis suppressor by disrupting the migratory complex, PIX-GIT- Paxillin, in cancer cells.
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- Perng, Bo Hao, et al.
(författare)
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Mapping distribution of woody plant species richness from field rapid assessment and machine learning
- 2024
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Ingår i: Taiwania. - 0372-333X. ; 69, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Sustainable forest management needs information on spatial distribution of species richness. The objectives of this study were to understand whether knowledge, method, and effort of a rapid assessment affected accuracy and consistency in mapping species richness. A simulation study was carried out with nine 25–50 ha census plots located in tropical, subtropical, and temperate zones. Each forest site was first tessellated into non-overlapping cells. Rapid assessment was conducted in all cells to generate a complete coverage of proxies of the underlying species richness. Cells were subsampled for census, where all plant individuals were identified to species in these census cells. An artificial neural network model was built using the census cells that contain rapid assessment and census information. The model then predicted species richness of cells that were not censused. Results showed that knowledge level did not improve the accuracy and consistency in mapping species richness. Rapid assessment effort and method significantly affected the accuracy and consistency. Increasing rapid assessment effort from 10 to 40 plant individuals could improve the accuracy and consistency up to 2.2% and 2.8%, respectively. Transect reduced accuracy and consistency by up to 0.5% and 0.8%, respectively. This study suggests that knowing at least half of the species in a forest is sufficient for a rapid assessment. At least 20 plant individuals per cell is recommended for rapid assessment. Lastly, a rapid assessment could be carried out by local communities that are familiar with their forests; thus, further supporting sustainable forest management.
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- Piponiot, Camille, et al.
(författare)
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Distribution of biomass dynamics in relation to tree size in forests across the world
- 2022
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Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 234, s. 1664-1677
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Tidskriftsartikel (refereegranskat)abstract
- Tree size shapes forest carbon dynamics and determines how trees interact with their environment, including a changing climate. Here, we conduct the first global analysis of among-site differences in how aboveground biomass stocks and fluxes are distributed with tree size. We analyzed repeat tree censuses from 25 large-scale (4–52 ha) forest plots spanning a broad climatic range over five continents to characterize how aboveground biomass, woody productivity, and woody mortality vary with tree diameter. We examined how the median, dispersion, and skewness of these size-related distributions vary with mean annual temperature and precipitation. In warmer forests, aboveground biomass, woody productivity, and woody mortality were more broadly distributed with respect to tree size. In warmer and wetter forests, aboveground biomass and woody productivity were more right skewed, with a long tail towards large trees. Small trees (1–10 cm diameter) contributed more to productivity and mortality than to biomass, highlighting the importance of including these trees in analyses of forest dynamics. Our findings provide an improved characterization of climate-driven forest differences in the size structure of aboveground biomass and dynamics of that biomass, as well as refined benchmarks for capturing climate influences in vegetation demographic models.
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