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Sökning: WFRF:(Sudo Takeaki)

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1.
  • Ikawa, Takahiro, et al. (författare)
  • Clinical comparison of an electric-powered ionic toothbrush and a manual toothbrush in plaque reduction : A randomized clinical trial
  • 2020
  • Ingår i: International Journal of Dental Hygiene. - : John Wiley & Sons. - 1601-5029 .- 1601-5037. ; 19:1, s. 93-98
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: This study aimed to evaluate the plaque removal efficacy of a newly-developed electric-powered ionic toothbrush vs. a manual toothbrush.MATERIALS AND METHODS: Manual or electric-powered ionic toothbrushes were randomly assigned to 30 healthy volunteers divided into two groups (Phase I). After 2-minutes of brushing, all teeth surfaces were stained with a plaque staining solution, and blinded examiners performed scoring using the Rustogi Modification of the Navy Plaque Index. Plaque removal rate was calculated at the central incisors, first premolar, and first molar, as representative teeth, in the maxilla and mandibula. One week following Phase I, the same examinations were repeated in all subjects using another toothbrush (Phase II), as a cross-over design.RESULTS: Electric ionic toothbrushes demonstrated a significantly higher plaque removal rate than manual toothbrushes in the premolar and molar areas (p < 0.05). However, in the central incisor area, no statistically significant difference was observed.CONCLUSIONS: Compared to manual toothbrushes, electric-powered ionic ones were significantly efficient in removing plaque in the premolar and molar areas.
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2.
  • Shungin, Dmitry, et al. (författare)
  • Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
  • 2019
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.
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