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| 2. |
- Beaumont, Robin N, et al.
(författare)
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Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.
- 2023
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Ingår i: Nature genetics. - 1546-1718 .- 1061-4036. ; 55:11, s. 1807-19
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Tidskriftsartikel (refereegranskat)abstract
- A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.
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| 3. |
- Chakravarty, D., et al.
(författare)
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Zirconia-Nanoparticle-Reinforced Morphology-Engineered Graphene-Based Foams
- 2015
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Ingår i: Advanced Materials. - : Wiley. - 0935-9648. ; 27:31, s. 4534-4543
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Tidskriftsartikel (refereegranskat)abstract
- The morphology of graphene-based foams can be engineered by reinforcing them with nanocrystalline zirconia, thus improving their oil-adsorption capacity; This can be observed experimentally and explained theoretically. Low zirconia fractions yield flaky microstructures where zirconia nanoparticles arrest propagating cracks. Higher zirconia concentrations possess a mesh-like interconnected structure where the degree of coiling is dependant on the local zirconia content. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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| 5. |
- Schillemans, Tessa, et al.
(författare)
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Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease : An Individual-Level Meta-Analysis
- 2022
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Ingår i: Frontiers in Physiology. - : Frontiers Media S.A.. - 1664-042X. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One potential pathway is related to peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A), a transcription factor linked to energy metabolism which may play a role in the heart function. Thus, its associations with subsequent CHD events remain unclear. We aimed to investigate the effect of three different SNPs in the PPARGC1A gene on the risk of subsequent CHD in a population with established CHD.Methods: We employed an individual-level meta-analysis using 23 studies from the GENetIcs of sUbSequent Coronary Heart Disease (GENIUS-CHD) consortium, which included participants (n = 80,900) with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. Three variants in the PPARGC1A gene (rs8192678, G482S; rs7672915, intron 2; and rs3755863, T528T) were tested for their associations with subsequent events during the follow-up using a Cox proportional hazards model adjusted for age and sex. The primary outcome was subsequent CHD death or myocardial infarction (CHD death/myocardial infarction). Stratified analyses of the participant or study characteristics as well as additional analyses for secondary outcomes of specific cardiovascular disease diagnoses and all-cause death were also performed.Results: Meta-analysis revealed no significant association between any of the three variants in the PPARGC1A gene and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline: rs8192678, hazard ratio (HR): 1.01, 95% confidence interval (CI) 0.98-1.05 and rs7672915, HR: 0.97, 95% CI 0.94-1.00; rs3755863, HR: 1.02, 95% CI 0.99-1.06. Similarly, no significant associations were observed for any of the secondary outcomes. The results from stratified analyses showed null results, except for significant inverse associations between rs7672915 (intron 2) and the primary outcome among 1) individuals aged >= 65, 2) individuals with renal impairment, and 3) antiplatelet users.Conclusion: We found no clear associations between polymorphisms in the PPARGC1A gene and subsequent CHD events in patients with established CHD at baseline.
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| 6. |
- Soma Raju, K. R. C., et al.
(författare)
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Electro-spark coatings for enhanced performance of twist drills
- 2008
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Ingår i: Surface & Coatings Technology. - 0257-8972 .- 1879-3347. ; 202:9, s. 1636-1644
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Tidskriftsartikel (refereegranskat)abstract
- Surface engineering approaches are being increasingly employed for enhancing the effective life of twist drills with a view to reduce machining costs. The electro-spark coating (ESC) technique provides a promising means of depositing wear resistant coatings that can potentially enhance the performance of these tools. However, it is often necessary to also optimize the machining conditions for coated tools to achieve an enhanced tool life. In the present investigation, varying spindle speeds were employed at a fixed vertical feed to evaluate the performance of WC-8Co ESC coated HSS drills in comparison to bare HSS drills. The number of holes drilled before reaching a preset average flank wear (0.5 mm), or catastrophic failure of the drill, was taken as the measure of tool life. The drill flank wear, monitored at regular intervals, as well as the cutting torque and thrust measured for all holes, were considered to be the key criteria for optimizing the cutting conditions. Results indicate that the WC-8Co coated drill tool life can be increased by a factor of more than 5, depending on the machining conditions selected. Furthermore, flank wear of the drill was found to increase rapidly at the end of drill life. Cutting torque data was also found to provide a useful indicator for predicting the end of tool life. © 2007 Elsevier B.V. All rights reserved.
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| 7. |
- Sundararajan, G., et al.
(författare)
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Thermal spraying in India : Status and prospects
- 2009
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Ingår i: Proceedings of the International Thermal Spray Conference. ; , s. 511-516
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Konferensbidrag (refereegranskat)abstract
- Notwithstanding the fact that the thermal spray technologies have globally proliferated into virtually all major industry segments, the acceptance of these processes by the Indian industry had been historically sluggish. However, the scenario in the country with respect to the thermal spray technologies is rapidly changing. A meaningful indicator of the obvious growth of thermal spraying is the spurt in the number of job shops, equipped with the latest thermal spray variants and sophisticated job-handling capabilities, that can now offer coating service. The number of captive units meeting in-house coating needs has also increased markedly in recent years. The non-availability of indigenous sources for thermal spray equipment as well as feedstock materials had been one of the key factors hampering growth of the thermal spray industry in India. The increasing adoption of thermal spraying by the Indian industry has been spurred by the fact that home-grown Indian companies are manufacturing spray systems, handling equipment and performance evaluation test rigs that are already being exported to foreign countries. Research on frontier areas like Cold Gas Dynamic Spraying and Solution Precursor Plasma Spraying is also active in the country. The above factors, along with the healthy growth trends observed recently, suggest a very bright future for thermal spray technologies in India. This paper provides an overview of the country status, charting the growth of thermal spray coatings in India in recent times. Copyright © 2009 ASM International® All rights reserved.
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