| 1. |
- Berg, Marcus, 1973-, et al.
(författare)
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Manifest modular invariance in the near-critical Ising model
- 2024
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Ingår i: Journal of Statistical Mechanics. - : Institute of Physics (IOP). - 1742-5468. ; 2024:1
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Tidskriftsartikel (refereegranskat)abstract
- Using recent results in mathematics, I point out that free energies and scale-dependent central charges away from criticality can be represented in compact form where modular invariance is manifest. The main example is the near-critical Ising model on a thermal torus, but the methods are not restricted to modular symmetry, and apply to automorphic symmetries more generally. One application is finite-size effects.
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| 2. |
- Uhlén, Mathias, et al.
(författare)
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A human protein atlas for normal and cancer tissues based on antibody proteomics
- 2005
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
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Tidskriftsartikel (refereegranskat)abstract
- Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
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| 3. |
- Andersson, Maria, et al.
(författare)
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Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia
- 2023
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Ingår i: Journal of Hematology. - : Elmer Press, Inc.. - 1927-1212 .- 1927-1220. ; 12:4, s. 170-175
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Tidskriftsartikel (refereegranskat)abstract
- Background: Patients with chronic lymphocytic leukemia (CLL) are vulnerable to coronavirus disease 2019 (COVID-19) and are at risk of inferior response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, especially if treated with the first-generation Bruton’s tyrosine kinase inhibitor (BTKi) ibrutinib. We aimed to evaluate the impact of the third-generation BTKi, zanubrutinib, on systemic and mucosal response to SARS-CoV-2 vaccination.Methods: Nine patients with CLL with ongoing zanubrutinib therapy were included and donated blood and saliva during SARS-CoV-2 vaccination, before vaccine doses 3 and 5 and 2 - 3 weeks after doses 3, 4, and 5. Ibrutinib-treated control patients (n = 7) and healthy aged-matched controls (n = 7) gave blood 2 - 3 weeks after vaccine dose 5. We quantified reactivity and neutralization capacity of SARS-CoV-2-specific IgG and IgA antibodies (Abs) in both serum and saliva, and reactivity of T cells activated with viral peptides.Results: Both zanubrutinib- and ibrutinib-treated patients had significantly, up to 1,000-fold, lower total spike-specific Ab levels after dose 5 compared to healthy controls (P < 0.01). Spike-IgG levels in serum from zanubrutinib-treated patients correlated well to neutralization capacity (r = 0.68; P < 0.0001) and were thus functional. Mucosal immunity (specific IgA in serum and saliva) was practically absent in zanubrutinib-treated patients even after five vaccine doses, whereas healthy controls had significantly higher levels (tested in serum after vaccine dose 5) (P < 0.05). In contrast, T-cell reactivity against SARS-CoV-2 peptides was equally high in zanubrutinib- and ibrutinib-treated patients as in healthy control donors.Conclusions: In our small cohort of zanubrutinib-treated CLL patients, we conclude that up to five doses of SARS-CoV-2 vaccination induced no detectable IgA mucosal immunity, which likely will impair the primary barrier defence against the infection. Systemic IgG responses were also impaired, whereas T-cell responses were normal. Further and larger studies are needed to evaluate the impact of these findings on disease protection.
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| 4. |
- Anderstig, Christer, et al.
(författare)
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Integrating SCGE and I-O in Multiregional Modelling
- 2013
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Ingår i: Employment Location in Cities and Regions. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642317781 - 9783642317798 ; , s. 159-180
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Economic activities can be modeled at different levels of aggregation. Different levels of detail regarding spatial or temporal resolution, or levels of sectoral aggregation are appropriate depending on the question at hand. In cases where changes on the micro scale affects what happens at the macro level, and vice versa, an integrated approach is required. In this paper a modeling framework is presented, where focus is placed on the interactions between production and employment. The aggregate spatial computable general equilibrium model STRAGO is interacted with the highly detailed input-output model system rAps. Interregional and intersectoral relations of production, including agglomeration, are represented in the aggregate model, providing a coarse description of production by which the rAps model system is constrained. Such constraints will affect where individuals may find a suitable job. At the same time the aggregate model is dependent on the labour supply, provided by rAps, in determining production. An application of the proposed modeling framework is presented where future projections are compared to historical data.
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| 5. |
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| 6. |
- Blom Västberg, Oskar, 1987-, et al.
(författare)
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A dynamic discrete choice activitybased travel demand model
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- During the last decades, many activity-based models have been developed in the literature. However, especially in random utility based models timing decisions are often treated poorly or inconsistently with other choice dimensions. In this paper we show how dynamic discrete choice can be used to overcome this problem. In the proposed model, trip decisions are made sequentially in time, starting at home in the morning and ending at home in the evening. At each decision stage, the utility of an alternative is the sum of the one-stage utility of the action and the expected future utility in the reached state.The model generates full daily activity schedules with any number of trips that each is a combination of one of 6 activities, 1240 locations and 4 modes. The ability to go from all to all locations makes evaluating the model very time consuming and sampling of alternatives were therefore used for estimation. The model is estimated on travel diaries and simulation results indicates that it is able to reproduce timing decisions, trip lengths and distribution of the number trips within sample.To explain when people perform different activities, two sets of parameters are used: firstly, the utility of being at home varies depending on the time of day; and secondly, constants determine the utility of arriving to work at specific times. This was enough to also obtain a good distribution of the starting times for free-time activities.
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| 7. |
- Blom Västberg, Oskar, 1987-
(författare)
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Five papers on large scale dynamic discrete choice models of transportation
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Travel demand models have long been used as tools by decision makers and researchers to analyse the effects of policies and infrastructure investments. The purpose of this thesis is to develop a travel demand model which is: sensitive to policies affecting timing of trips and time-space constraints; is consistent with microeconomics; and consistently treats the joint choice of the number of trips to perform during day as well as departure time, destination and mode for all trips. This is achieved using a dynamic discrete choice model (DDCM) of travel demand. The model further allows for a joint treatment of within-day travelling and between-day activity scheduling assuming that individuals are influenced by the past and considers the future when deciding what to do on a certain day.Paper I develops and provides estimation techniques for the daily component of the proposed travel demand model and present simulation results provides within sample validation of the model. Paper II extends the model to allow for correlation in preferences over the course of a day using a mixed-logit specification. Paper III introduces a day-to-day connection by using an infinite horizon DDCM. To allow for estimation of the combined model, Paper III develops conditions under which sequential estimation can be used to estimate very large scale DDCM models in situations where: the discrete state variable is partly latent but transitions are observed; the model repeatedly returns to a small set of states; and between these states there is no discounting, random error terms are i.i.d Gumble and transitions in the discrete state variable is deterministic given a decision.Paper IV develops a dynamic discrete continuous choice model for a household deciding on the number of cars to own, their fuel type and the yearly mileage for each car. It thus contributes to bridging the gap between discrete continuous choice models and DDCMs of car ownership.Infinite horizon DDCMs are commonly found in the literature and are used in, e.g., Paper III and IV in this thesis. It has been well established that the discount factor must be strictly less than one for such models to be well defined.Paper V show that it is possible to extend the framework to discount factors greater than one, allowing DDCM's to describe agents that: maximize the average utility per stage (when there is no discounting); value the future greater than the present and thus prefers improving sequences of outcomes implying that they take high costs early and reach a potential terminal state sooner than optimal.
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| 8. |
- Fadaei, Masoud, et al.
(författare)
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Consistently estimating link speed using sparse GPS data with measured errors
- 2014
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Ingår i: Transportation. - : Elsevier. ; , s. 829-838
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Konferensbidrag (refereegranskat)abstract
- Data sources using new technology such as the Geographical Positioning System are increasingly available. In many different applications, it is important to predict the average speed on all the links in a network. The purpose of this study is to estimate the link speed in a network using sparse GPS data set. Average speed is consistently estimated using Indirect Inference approach. in the end, the Monte Carlo evidence is provided to show that the results are consistent with parameter estimates.
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| 9. |
- Fadaei, Masoud, et al.
(författare)
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Estimating flexible route choice models using sparse data
- 2012
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Ingår i: Intelligent Transportation Systems (ITSC), 2012 15th International IEEE Conference on. - : IEEE conference proceedings. - 9781467330640 ; , s. 1215-1220
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Konferensbidrag (refereegranskat)abstract
- GPS and nomad devices are increasingly used to provide data from individuals in urban traffic networks. In many different applications, it is important to predict the continuation of an observed path, and also, given sparse data, predict where the individual (or vehicle) has been. Estimating the perceived cost functions is a difficult statistical estimation problem, for different reasons. First, the choice set is typically very large. Second, it may be important to take into account the correlation between the (generalized) costs of different routes, and thus allow for realistic substitution patterns. Third, due to technical or privacy considerations, the data may be temporally and spatially sparse, with only partially observed paths. Finally, the position of vehicles may have measurement errors. We address all these problems using a indirect inference approach. We demonstrate the feasibility of the proposed estimator in a model with random link costs, allowing for a natural correlation structure across paths, where the full choice set is considered.
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