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- Alhuseinalkhudhur, Ali, et al.
(författare)
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Human Epidermal Growth Factor Receptor 2-Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.
- 2023
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Ingår i: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667. ; 64:9, s. 1364-1370
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Tidskriftsartikel (refereegranskat)abstract
- Imaging using the human epidermal growth factor receptor 2 (HER2)-binding tracer 68Ga-labeled ZHER2:2891-Cys-MMA-DOTA ([68Ga]Ga-ABY-025) was shown to reflect HER2 status determined by immunohistochemistry and in situ hybridization in metastatic breast cancer (MBC). This single-center open-label phase II study investigated how [68Ga]Ga-ABY-025 uptake corresponds to biopsy results and early treatment response in both primary breast cancer (PBC) planned for neoadjuvant chemotherapy and MBC. Methods: Forty patients with known positive HER2 status were included: 19 with PBC and 21 with MBC (median, 3 previous treatments). [68Ga]Ga-ABY-025 PET/CT, [18F]F-FDG PET/CT, and core-needle biopsies from targeted lesions were performed at baseline. [18F]F-FDG PET/CT was repeated after 2 cycles of therapy to calculate the directional change in tumor lesion glycolysis (Δ-TLG). The largest lesions (up to 5) were evaluated in all 3 scans per patient. SUVs from [68Ga]Ga-ABY-025 PET/CT were compared with the biopsied HER2 status and Δ-TLG by receiver operating characteristic analyses. Results: Trial biopsies were HER2-positive in 31 patients, HER2-negative in 6 patients, and borderline HER2-positive in 3 patients. The [68Ga]Ga-ABY-025 PET/CT cutoff SUVmax of 6.0 predicted a Δ-TLG lower than -25% with 86% sensitivity and 67% specificity in soft-tissue lesions (area under the curve, 0.74 [95% CI, 0.67-0.82]; P = 0.01). Compared with the HER2 status, this cutoff resulted in clinically relevant discordant findings in 12 of 40 patients. Metabolic response (Δ-TLG) was more pronounced in PBC (-71% [95% CI, -58% to -83%]; P < 0.0001) than in MBC (-27% [95% CI, -16% to -38%]; P < 0.0001), but [68Ga]Ga-ABY-025 SUVmax was similar in both with a mean SUVmax of 9.8 (95% CI, 6.3-13.3) and 13.9 (95% CI, 10.5-17.2), respectively (P = 0.10). In multivariate analysis, global Δ-TLG was positively associated with the number of previous treatments (P = 0.0004) and negatively associated with [68Ga]Ga-ABY-025 PET/CT SUVmax (P = 0.018) but not with HER2 status (P = 0.09). Conclusion: [68Ga]Ga-ABY-025 PET/CT predicted early metabolic response to HER2-targeted therapy in HER2-positive breast cancer. Metabolic response was attenuated in recurrent disease. [68Ga]Ga-ABY-025 PET/CT appears to provide an estimate of the HER2 expression required to induce tumor metabolic remission by targeted therapies and might be useful as an adjunct diagnostic tool.
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- Byström, Tora, 1960-
(författare)
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Nordens Frihet : Samfundet, tidningen, kretsen
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The thesis deals with "Samfundet Nordens Frihet" ['The Association Scandinavia’s Freedom'], its magazine with the same name, Nordens Frihet, and the circle that constituted the magazine’s editorial committee. Nordens Frihet was founded as a direct consequence of the outbreak of the Finnish Winter War on November 30 1939 and was a very active part of the Swedish Finland Movement. The Soviet attack on Finland was seen as a threat to Sweden and the whole of Scandinavia too, and after the harsh peace settlement in March 1940, Nordens Frihet made propaganda for a Nordic defence union in protection against renewed attacks from the East. When on April 9 1940 Germany attacked and occupied Denmark and Norway, Nordens Frihet took sides wholeheartedly against the Nazi occupying power too. The magazine thereby became a dedicated anti-Nazi voice in Sweden during the Second World War. The magazine’s editorial committee – "the circle" – is at the centre of the thesis. It was a group of ten persons that in practice formed and expressed the association's political line. The aim of the thesis is to investigate Nordens Frihet and its political standpoints during the Second World War. This is done partly by describing the association and its inner circle – the editorial committee – and partly by analysing their views. Part I of the thesis, "Personerna" ['The Persons'], deals with the association, the circle and the anti-Nazi networks that Nordens Frihet was a part of. They included anti-Nazi oriented publicists and editors, the partially similar associations "Förbundet Kämpande Demokrati" ['the Federation Struggling Democracy'] and "Tisdagsklubben" ['the Tuesday Club'], Western-allied diplomats stationed in Stockholm and Nordic contacts. The chapter on the editorial committee shows how it became a closely united circle of lifelong friends. Their mutual relations are studied as well as their political orientation. In addition the concepts 'friendship' and 'circles' are discussed. Part II, "Åsikterna" ['The Views'], investigates and analyses Nordens Frihet’s political stances. Was it possible to combine the strong Nordic commitment with an equally dedicated anti-Nazi standpoint? The question was brought to a head when in the summer of 1941 Finland again went to war against the Soviet Union, but this time side by side with Nazi Germany, which at the same time was occupying and oppressing Denmark and Norway. Scandinavia was thus more divided than ever. In spite of this Nordens Frihet made propaganda for Nordic unity, a Nordic defence union, even a Nordic political union. The thesis also investigates Nordens Frihet’s attitude to the Swedish Communists, democracy, parliamentarism, anti-Semitism, neutrality, and their understanding of being "national". Nordens Frihet was discontinued in December 1945, but the circle kept up their contacts. When the conflicts between East and West gradually increased, the circle harboured serious – but not implemented – plans to restart the magazine. In the climate of the Cold War they thought that Sweden would have to abandon its isolationistic neutrality and instead join a Western alliance.
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- Friberg, Tora, 1945-, et al.
(författare)
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Ett segregerat samhälle
- 1985
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Ingår i: Dagens nyheter. - 1101-2447. ; :29 april 1985
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
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