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- Villain, Lucile, et al.
(författare)
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Evaluation of the effectiveness of backfilling and sealing at an open-pit mine using ground penetrating radar and geoelectrical surveys, Kimheden, northern Sweden
- 2014
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Ingår i: Environmental Earth Sciences. - : Springer Science and Business Media LLC. - 1866-6280 .- 1866-6299. ; 73:8, s. 4495-4509
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Tidskriftsartikel (refereegranskat)abstract
- At Kimheden, a small copper mine in northern Sweden, reclamation of the two open pits was investigated using ground penetrating radar and geoelectrical multiple-gradient array measurements. The pits had been backfilled with waste rock, with a dry cover being applied on top in 1996 in order to reduce the influx of oxygen to the sulphidic mine waste and the subsequent production of acid mine drainage. The dry cover consists of a sealing layer of clayey till and a protective layer of unsorted till. As geochemical sampling in the drainage from the pits had previously revealed the continued release of contaminating oxidation products, the purpose of the geophysical survey undertaken in 2010 was to identify deficiencies in the cover or other pathways for oxygen to reach the waste rock. The radar images did not reveal any damage in the sealing layer but risks of deterioration of the cover in the long term were identified with both the radar and geoelectrical data. The radar localised regions of thinner protective layer where the sealing layer could be exposed to frost action. The geoelectrical measurements indicated the existence of seepage through the dry cover that presented a risk of erosion of the sealing layer. 2-D inversion of geoelectrical data also imaged some pathways of groundwater around the main pit. The results from the geophysical investigations were used together with other site data in order to show that both deficiencies in the cover and superficial fractures in the pit walls may explain an ongoing influx of oxygen to the mine waste.
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- Ahmed, Mobyen Uddin, Dr, 1976-, et al.
(författare)
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Data Analysis on Powered Two Wheelers Riders’ Behaviour using Machine Learning
- 2019
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Ingår i: First International Conference on Advances in Signal Processing and Artificial Intelligence ASPAI' 2019. - Barcelona, Spain.
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Konferensbidrag (refereegranskat)abstract
- Analyzing powered two-wheeler rider behavior, i.e. classification of riding patterns based on 3-D accelerometer/gyroscope sensors mounted on motorcycles is challenging. This paper presents machine learning approach to classify four different riding events performed by powered two wheeler riders’ as a step towards increasing traffic safety. Three machine learning algorithms, Random Forest (RF), Support Vector Machine (SVM) and Artificial Neural Network (ANN) have been used to classify riding patterns. The classification is conducted based on features extracted in time and frequency domains from accelerometer/gyroscope sensors signals. A comparison result between different filter frequencies, window sizes, features sets, as well as machine learning algorithms is presented. According to the results, the Random Forest method performs most consistently through the different data sets and scores best.
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| 5. |
- Andersson, Catrin, et al.
(författare)
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Att organisera marknader : slutrapport från ett forskningsprogram
- 2015
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Forskningsprogrammet ”Att organisera marknader” har drivits vid Stockholms centrum för forskning om offentlig sektor (Score) och finansierats av Riksbankens Jubileumsfond. I denna bok redovisar vi några resultat från programmet. Boken bygger på ett stort antal böcker och artiklar vilka anges i slutet av boken. En fullständig förteckning av alla de publikationer som programmet hittills gett upphov till finns att tillgå på rj.se. Denna bok har flera författare förutom undertecknad: Susanna Alexius, Catrin Andersson, Patrik Aspers, Christina Garsten, Magnus Erlandsson, Kristoffer Strandqvist, Göran Sundström och Kristina Tamm Hallström. Samtliga är verksamma som forskare vid Score.
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| 6. |
- Aspenström-Fagerlund, Bitte, et al.
(författare)
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Fatty acids increase paracellular absorption of aluminium across Caco-2 cell monolayers
- 2009
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Ingår i: Chemico-Biological Interactions. - : Elsevier BV. - 0009-2797 .- 1872-7786. ; 181:2, s. 272-278
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Tidskriftsartikel (refereegranskat)abstract
- Passive paracellular absorption, regulated by tight junctions (TJs), is the main route for absorption of poorly absorbed hydrophilic substances. Surface active substances, such as fatty acids, may enhance absorption of these substances by affecting the integrity of TJ and increasing the permeability. It has been suggested that aluminium (Al) absorption occurs mainly by the paracellular route. Herein, we investigated if physiologically relevant exposures of fully differentiated Caco-2 cell monolayers to oleic acid and docosahexaenoic acid (DHA), which are fatty acids common in food, increase absorption of Al and the paracellular marker mannitol. In an Al toxicity test, mannitol and Al absorption through Caco-2 cell monolayers were similarly modulated by Al concentrations between 1 and 30mM, suggesting that absorption of the two compounds occurred via the same pathways. Exposure of Caco-2 cell monolayers to non-toxic concentrations of Al (2mM) and (14)C-mannitol in fatty acid emulsions (15 and 30mM oleic acid, 5 and 10mM DHA) caused a decreased transepithelial electrical resistance (TEER). Concomitantly, fractional absorption of Al and mannitol, expressed as percentage of apical Al and mannitol retrieved at the basolateral side, increased with increasing dose of fatty acids. Transmission electron microscopy was applied to assess the effect of oleic acid on the morphology of TJ. It was shown that oleic acid caused a less structured morphology of TJ in Caco-2 cell monolayers. Taken together our findings indicate that fatty acids common in food increase the paracellular intestinal absorption of Al. These findings may influence future risk assessment of human Al exposure.
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| 8. |
- Baecklund, Eva, et al.
(författare)
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Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis
- 2006
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 54:3, s. 692-701
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:Chronic inflammatory conditions such as rheumatoid arthritis (RA) have been associated with malignant lymphomas. This study was undertaken to investigate which patients are at highest risk, and whether antirheumatic treatment is hazardous or protective.METHODS:We performed a matched case-control study of 378 consecutive Swedish RA patients in whom malignant lymphoma occurred between 1964 and 1995 (from a population-based RA cohort of 74,651 RA patients), and 378 controls. Information on disease characteristics and treatment from onset of RA until lymphoma diagnosis was abstracted from medical records. Lymphoma specimens were reclassified and tested for Epstein-Barr virus (EBV). Relative risks (odds ratios [ORs]) for lymphomas (by subtype) associated with deciles of cumulative disease activity were assessed, as were ORs associated with drug treatments.RESULTS:The relative risks of lymphoma were only modestly elevated up to the seventh decile of cumulative disease activity. Thereafter, the relative risk increased dramatically (OR ninth decile 9.4 [95% confidence interval 3.1-28.0], OR tenth decile 61.6 [95% confidence interval 21.0-181.0]). Most lymphomas (48%) were of the diffuse large B cell type, but other lymphoma subtypes also displayed an association with cumulative disease activity. Standard nonbiologic treatments did not increase lymphoma risk. EBV was present in 12% of lymphomas.CONCLUSION:Risk of lymphoma is substantially increased in a subset of patients with RA, those with very severe disease. High inflammatory activity, rather than its treatment, is a major risk determinant.
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| 9. |
- Baecklund, Eva, et al.
(författare)
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Characteristics of diffuse large B cell lymphomas in rheumatoid arthritis
- 2006
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 54:12, s. 3774-3781
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas, with a correlation between RA disease severity and lymphoma risk, most pronounced for diffuse large B cell lymphomas (DLBCLs), which also constitute the majority of RA-associated lymphomas. DLBCLs can be further subdivided into germinal center (GC)-like and non-GC-like subtypes, with different cellular origins and prognoses. This study was undertaken to investigate whether RA displays a specific association with any of the DLBCL subtypes.METHODS:We identified 139 patients with DLBCLs within a population-based case-control study of 378 RA patients with lymphoma. The DLBCLs were examined for CD10, Bcl-6, and interferon regulatory factor 4 expression patterns, subclassified into GC and non-GC subtypes, and then correlated with clinical parameters.RESULTS:We found a statistically significant predominance of the non-GC subtype (97 patients; 70% of all DLBCLs). These patients more often had an advanced stage of lymphoma at diagnosis and had a worse 5-year overall survival rate (16% versus 33%) compared with patients with the GC subtype. There was a strong association with RA disease activity in both subtypes, with >70% of the GC and non-GC cases occurring in RA patients with the highest overall disease activity scores.CONCLUSION: These findings suggest that severe RA is particularly associated with the non-GC subtype of DLBCL, and indicate a critical role of activated peripheral B cells as the cells of origin in these lymphomas.
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