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| 2. |
- Bergendal, Annica, et al.
(författare)
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Non-steroidal anti-inflammatory drugs and venous thromboembolism in women
- 2013
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Ingår i: Pharmacoepidemiology and Drug Safety. - : Wiley. - 1053-8569 .- 1099-1557. ; 22:6, s. 658-666
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Tidskriftsartikel (refereegranskat)abstract
- Background Non-steroidal anti-inflammatory drugs (NSAIDs) might increase the risk of venous thromboembolism (VTE), and risks might differ by type of NSAID. Compared with men, women have a higher incidence of VTE at younger age, and they more often use NSAIDs. Objectives To assess risks of VTE in young and middle-aged women in association with use of NSAIDs. Patients/Methods In a nationwide case-control study (Thrombo Embolism Hormone Study) performed in Sweden 2003-2009, we included as cases 1433 women, 18 to 64years of age with a first time VTE. Controls were 1402 randomly selected women, frequency matched by age. Information was obtained by telephone interviews and DNA analyses of blood samples. We calculated adjusted odds ratios (ORs) with 95% confidence intervals (CIs) adjusting for degree of immobilization, chronic disease, smoking, body mass index, use of hormonal contraception, hormone therapy or other NSAIDs. Results Use of NSAIDs was not associated with increased risks of VTE (OR=0.98, 95% CI 0.80-1.19). The OR was 0.88 for propionic acid derivatives (95% CI 0.72-1.10), 1.18 for acetic acid derivatives (95% CI 0.82-1.70) and 1.76 for coxibs (95% CI 0.73-4.27). For users of acetic acid derivatives and coxibs, the ORs increased by cumulative dose. Carriership of the prothrombin gene mutation or factor V Leiden had only minor effects on the results. Conclusions We found no increased risks of VTE in association with use of NSAIDs. Users of high cumulative doses of acetic acid derivatives and coxibs had the highest risks, suggesting a relationship with cyclooxygenase selectivity and dose.
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| 3. |
- Bergendal, Annica, et al.
(författare)
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Risk factors for venous thromboembolism in pre- and postmenopausal women
- 2012
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Ingår i: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 130:4, s. 596-601
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionHemostasis in women is affected by changes of estrogen levels. The role of endogenous estrogens on risk of venous thromboembolism (VTE) remains unclear. The aim of this study was to investigate the importance of acquired and genetic risk factors for VTE in pre-and postmenopausal women.MethodIn a nationwide case–control study we included as cases 1470 women, 18 to 64 years of age with a first time VTE. The 1590 controls were randomly selected and matched by age to the cases. Information on risk factors was obtained by interviews and DNA-analyses. We used unconditional logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs).ResultsThe ORs were generally of similar magnitude in pre- and postmenopausal women. The highest risk was for the combination of surgery and cast (adjusted OR 54.12, 95% CI 16.62-176.19) in postmenopausal women. The adjusted OR for use of menopausal hormone therapy was 3.73 (95% CI 1.86-7.50) in premenopausal and 2.22 (95% CI 1.54-3.19) in postmenopausal women. Overweight was linked to an increased risk and exercise to a decreased risk, regardless of menopausal status.ConclusionMenopausal status had only minor influence on the risk levels. Acquired transient risk factors conveyed the highest risks for VTE.
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| 4. |
- Callbo, Paliz Nordlof, et al.
(författare)
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Novel Associations Between Mid-Pregnancy Cardiovascular Biomarkers and Preeclampsia: An Explorative Nested Case-Control Study
- 2024
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Ingår i: REPRODUCTIVE SCIENCES. - 1933-7191 .- 1933-7205.
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Tidskriftsartikel (refereegranskat)abstract
- Prediction of women at high risk of preeclampsia is important for prevention and increased surveillance of the disease. Current prediction models need improvement, particularly with regard to late-onset preeclampsia. Preeclampsia shares pathophysiological entities with cardiovascular disease; thus, cardiovascular biomarkers may contribute to improving prediction models. In this nested case-control study, we explored the predictive importance of mid-pregnancy cardiovascular biomarkers for subsequent preeclampsia. We included healthy women with singleton pregnancies who had donated blood in mid-pregnancy (similar to 18 weeks' gestation). Cases were women with subsequent preeclampsia (n = 296, 10% of whom had early-onset preeclampsia [< 34 weeks]). Controls were women who had healthy pregnancies (n = 333). We collected data on maternal, pregnancy, and infant characteristics from medical records. We used the Olink cardiovascular II panel immunoassay to measure 92 biomarkers in the mid-pregnancy plasma samples. The Boruta algorithm was used to determine the predictive importance of the investigated biomarkers and first-trimester pregnancy characteristics for the development of preeclampsia. The following biomarkers had confirmed associations with early-onset preeclampsia (in descending order of importance): placental growth factor (PlGF), matrix metalloproteinase (MMP-12), lectin-like oxidized LDL receptor 1, carcinoembryonic antigen-related cell adhesion molecule 8, serine protease 27, pro-interleukin-16, and poly (ADP-ribose) polymerase 1. The biomarkers that were associated with late-onset preeclampsia were BNP, MMP-12, alpha-L-iduronidase (IDUA), PlGF, low-affinity immunoglobulin gamma Fc region receptor II-b, and T cell surface glycoprotein. Our results suggest that MMP-12 is a promising novel preeclampsia biomarker. Moreover, BNP and IDUA may be of value in enhancing prediction of late-onset preeclampsia.
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| 5. |
- Ek, Staffan, et al.
(författare)
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A 28-nm FD-SOI 115-fs Jitter PLL-Based LO System for 24-30-GHz Sliding-IF 5G Transceivers
- 2018
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Ingår i: IEEE Journal of Solid-State Circuits. - 0018-9200. ; 53:7, s. 1988-2000
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Tidskriftsartikel (refereegranskat)abstract
- A system for local oscillator (LO) signal generation in 5G millimeter-wave (mmW) multi-antenna transceivers is presented. The system is modular with one phase locked loop (PLL) per antenna element transceiver, and a test circuit implemented in 28-nm fully depleted silicon on insulator (FD-SOI) CMOS features two such PLLs and a 491.52 MHz crystal oscillator (XO) generating a common frequency reference. A fractional-N architecture is employed to achieve high-frequency resolution, and the quantization noise is reduced using a novel frequency divider, which achieves full integer resolution while still using a pre-scaler. The system covers the 3rd Generation Partnership Project (3GPP) bands n257 and n258, achieved by a digital coarse tuning of the voltage-controlled oscillator (VCO). The chip area of each PLL is 0.11 mm², and 0.029 mm² for the XO. The total power consumption of the system is 35 mW, where each PLL consumes 15.4 mW and the XO consumes 0.84 mW. The total rms jitter from 20-kHz to 500-MHz offset for a 26-GHz carrier is just 115 fs, corresponding to an FOMj of -244 dB, which is the best reported figure for a fractional-N PLL above 15 GHz. The error-vector magnitude (EVM) due to phase noise is -34.6 dBc using an orthogonal frequency-division multiplexing (OFDM) signal with 120-kHz sub-carrier spacing, sufficient to support 256 QAM.
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| 8. |
- Osterroos, Anna, et al.
(författare)
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Associations between capillary glucose during pregnancy and childhood growth to the age of five : a cohort study
- 2022
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Ingår i: Scientific Reports. - : NATURE PORTFOLIO. - 2045-2322. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to evaluate the relationship between random capillary glucose levels in healthy pregnant women and infant size at birth and childhood growth to the age of five years. This population-based cohort study comprised 10,937 healthy mother-child dyads. Data on highest maternal random capillary glucose level during pregnancy and sequential anthropometric data on their children during the first five years of life were gathered from the Uppsala County Mother and Child Cohort. Statistical analyses were performed with linear regression and linear mixed effect regression models. We found that higher glucose level during pregnancy was associated with higher weight z-score (beta 0.10, 95% confidence interval (CI) 0.08-0.11), length z-score (beta 0.05, 95% CI 0.03-0.07) and BMI z-score (beta 0.09, 95% CI 0.07-0.12) at birth, adjusted for maternal BMI and country of birth, smoking during pregnancy and parity. The association did not remain at 11/2, 3, 4 and 5 years of age. There was a positive relationship between higher glucose level during pregnancy and a decrease in weight z-score, height z-score and BMI z-score from birth to 5 years of age. In conclusion, higher random capillary glucose levels in pregnant healthy women were associated with greater infant size at birth, as well as decreased growth velocity in early childhood.
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| 9. |
- Price, Douglas T., et al.
(författare)
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Origins of inhabitants from the 16th century Sala (Sweden) silver mine cemetery – A lead isotope perspective
- 2017
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Ingår i: Journal of Archaeological Science. - : Elsevier BV. - 0305-4403. ; 80, s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- Historical documents record the operation of a silver mine from the 16th century AD located near the former village of Salberget in central Sweden. The historical record describes several categories of inhabitants, including local families, workers and miners, foreign engineers and mining specialists, as well as war captives and criminals used as forced labor in the mines. A church yard in the vicinity of the village served as a burial ground. Archaeological evidence indicates two distinct grave types (coffin and earthen) and physical anthropology documents differences in age and sex between these grave types, as well as harsh conditions of life. Strontium and oxygen isotopes have been used previously to investigate the place of origin of the cemetery inhabitants and clear differences among the types of graves were seen in the isotope results. Place of origin was more difficult to ascertain however. Here we utilize lead isotopes as an additional isotopic tracer to identify origins. The lead isotope investigations pinpoint several areas outside of the Sala region where some of the inhabitants originated. In addition, the study documents the benefits of using lead isotopes in human proveniencing studies.
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| 10. |
- Saldeen, Pia, et al.
(författare)
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The probability of successful IVF outcome after poor ovarian response
- 2007
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 1600-0412 .- 0001-6349. ; 86:4, s. 457-461
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Tidskriftsartikel (refereegranskat)abstract
- Background. To evaluate the relationship between age and poor ovarian response to pregnancy and cancellation rate after IVF stimulation. Methods. Poor ovarian response was defined as <= 5 follicles at ovum pick up (OPU). Out of 1,706 consecutive OPUs performed during 2003/2004, 290 poor responders were identified. This cohort of poor responders was divided into two groups, 'older' and 'younger', with a cut-off at the median age of 37 years. The pregnancy and cancellation rates after OPU were analysed. Results. Women aged > 37 years, who were poor responders, had a significantly lower pregnancy rate per OPU (3.0%) compared to normal to high responders in the same age group (22.1%, p < 0.05). Also, 43.6% of women > 37 years, who were classified as poor responders, did not receive an embryo transfer ( ET), compared to 13.2% of normal to high responders in this age group ( p < 0.05). Poor responders who were 5/37 years had a significantly lower pregnancy rate/OPU compared to normal to high responders who were <= 37 years (14.0 versus 34.5%, p < 0.05) and a higher cancellation rate (40.1 versus 10.5%). Logistic regression analyses showed strong correlations between treatment outcome and the number of oocytes, age, and the mean and cumulative FSH dose given. The variable with the strongest impact on negative outcome was an interactive term between mean age and mean-FSH dose ( p = 5.0 x 10(-5)), indicating that women > 37 years, who receive high doses of FSH have a significantly poorer treatment outcome than can be explained by either age or FSH dose alone. Conclusions. Poor ovarian response after IVF stimulation requires thorough counselling prior to OPU, regardless of the woman's age. In poor responders > 37 years of age, especially those who require high FSH doses, we suggest that the decision whether or not to proceed to OPU should include the couple after thorough counselling, even though the chance of successful outcome is extremely low.
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