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1.
  • 2019
  • Tidskriftsartikel (refereegranskat)
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2.
  • Dhamal, Swapnil Vilas, 1988, et al. (författare)
  • Strategic Investments in Distributed Computing: A Stochastic Game Perspective
  • 2022
  • Ingår i: Journal of Parallel and Distributed Computing. - : Elsevier BV. - 1096-0848 .- 0743-7315. ; 169, s. 317-333
  • Tidskriftsartikel (refereegranskat)abstract
    • We study a stochastic game with a dynamic set of players, for modeling and analyzing their computational investment strategies in distributed computing. Players obtain a certain reward for solving a problem, while incurring a certain cost based on the invested time and computational power. We present our framework while considering a contemporary application of blockchain mining, and show that the framework is applicable to certain other distributed computing settings as well. For an in-depth analysis, we consider a particular yet natural scenario where the rate of solving the problem is proportional to the total computational power invested by the players. We show that, in Markov perfect equilibrium, players with cost parameters exceeding a certain threshold, do not invest; while those with cost parameters less than this threshold, invest maximal power. We arrive at an interesting conclusion that the players need not have information about the system state as well as each others' parameters, namely, cost parameters and arrival/departure rates. With extensive simulations and insights through mean field approximation, we study the effects of players' arrival/departure rates and the system parameters on the players' utilities.
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3.
  • Schosserer, Markus, et al. (författare)
  • Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan
  • 2015
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear. Here, we show that reduced levels of the conserved RNA methyltransferase NSUN5 increase the lifespan and stress resistance in yeast, worms and flies. Rcm1, the yeast homologue of NSUN5, methylates C2278 within a conserved region of 25S rRNA. Loss of Rcm1 alters the structural conformation of the ribosome in close proximity to C2278, as well as translational fidelity, and favours recruitment of a distinct subset of oxidative stress-responsive mRNAs into polysomes. Thus, rather than merely being a static molecular machine executing translation, the ribosome exhibits functional diversity by modification of just a single rRNA nucleotide, resulting in an alteration of organismal physiological behaviour, and linking rRNA-mediated translational regulation to modulation of lifespan, and differential stress response.
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