| 1. |
|
|
| 2. |
|
|
| 3. |
- Smith, H. G., et al.
(författare)
-
Variations in the definition and perceived importance of positive resection margins in patients with colorectal cancer - an EYSAC international survey
- 2023
-
Ingår i: EJSO. - 0748-7983 .- 1532-2157. ; 49:11
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: Microscopically positive resection margins (R1) are associated with poorer outcomes in patients with colorectal cancer. However, different definitions of R1 margins exist. It is unclear to what extent the definitions used in everyday clinical practice differ within and between nations. This study sought to investigate variations in the definition of R1 margins in colorectal cancer and the importance of margin status in clinical decision-making.Materials and methods: A 14-point survey was developed by members of The European Society of Surgical Oncology (ESSO) Youngs Surgeons and Alumni Club (EYSAC) Research Academy targeting all members of the multidisciplinary team (MDT) treating patients with colorectal cancer. The survey was distributed on social media, in ESSO's monthly newsletter and via national societies.Results: In total, 137 responses were received. Most respondents were from Europe (89.7%), with the majority from Denmark (56.9%). Less than 2/3 of respondents defined R1 margins as the presence of viable cancer cells <= 1 mm of the margin. Only 60% reported that subdivisions of R1 margins (primary tumour vs tumour deposit vs metastatic lymph node) are routinely available. More than 20% of respondents reported that pathology reports are not routinely reviewed at MDT meetings. Less than half of respondents considered margin status in decisionmaking for type and duration of adjuvant chemotherapy in Stage III colon cancer.Conclusion: The definitions and perceived clinical importance of microscopically positive margins in patients with colorectal cancer appear to vary. Adoption of an international dataset for pathology reporting may help to standardise current practices.
|
|
| 4. |
- Frómeta, D., et al.
(författare)
-
Fracture Resistance of Advanced High-Strength Steel Sheets for Automotive Applications
- 2021
-
Ingår i: Metallurgical and Materials Transactions. A. - : Springer. - 1073-5623 .- 1543-1940. ; 52:2, s. 840-856
-
Tidskriftsartikel (refereegranskat)abstract
- The fracture resistance of different advanced high-strength steel (AHSS) sheets for automotive applications is investigated through conventional tensile tests, fracture toughness measurements, and hole expansion tests. Different fracture-related parameters, such as the true fracture strain (TFS), the true thickness strain (TTS), the fracture toughness at crack initiation (wie), the specific essential work of fracture (we), and the hole expansion ratio (HER), are assessed. The specific essential work of fracture (we) is shown to be a suitable parameter to evaluate the local formability and fracture resistance of AHSS. The results reveal that fracture toughness cannot be estimated from any of the parameters derived from tensile tests and show the importance of microstructural features on crack propagation resistance. Based on the relation fracture toughness-local formability, a new AHSS classification mapping accounting for global formability and cracking resistance is proposed. Furthermore, a physically motivated fracture criterion for edge-cracking prediction, based on thickness strain measurements in fatigue pre-cracked DENT specimens, is proposed.
|
|
| 5. |
- Frómeta, D., et al.
(författare)
-
Microstructural effects on fracture toughness of ultra-high strength dual phase sheet steels
- 2021
-
Ingår i: Materials Science & Engineering. - : Elsevier. - 0921-5093 .- 1873-4936. ; 802
-
Tidskriftsartikel (refereegranskat)abstract
- The influence of microstructure on the fracture toughness of two industrially processed 1000 MPa dual-phase (DP) steel grades is investigated. Crack initiation and propagation resistance are evaluated by means of the essential work of fracture (EWF) methodology and the main damage and fracture mechanisms are investigated. The results are discussed in terms of the proportion and distribution of the different microstructural constituents, which is assessed by scanning electron microscopy (SEM), high-resolution electron backscatter diffraction (HR-EBSD) and nanoindentation hardness measurements. The investigations show that the strain-induced transformation of retained austenite to martensite (TRIP effect), may be detrimental to cracking resistance, even though it increases tensile properties. This phenomenon is attributed to a “brittle†network effect generated by the presence of hard fresh martensite islands in the fracture process zone. The connectivity of the hard secondary phases and the proportion of soft phase (ferrite) also have a major role in fracture toughness. The DP steel with the larger volume fraction of ferrite and homogeneously distributed martensite islands shows significantly higher crack propagation resistance. The contribution of necking to the ductile fracture process is evaluated by means of thickness measurements in fractured DENT specimens and the correlation between the specific essential work of fracture (we) and tensile properties is investigated. It is concluded that the global formability and cracking resistance of high strength DP steels can be balanced through microstructural tailoring. © 2020 The Author(s)
|
|
| 6. |
- Frómeta, D., et al.
(författare)
-
On the correlation between fracture toughness and crash resistance of advanced high strength steels
- 2019
-
Ingår i: Engineering Fracture Mechanics. - : Elsevier. - 0013-7944 .- 1873-7315. ; 205, s. 319-332
-
Tidskriftsartikel (refereegranskat)abstract
- Automotive industry players have devoted large efforts to identify the material parameters governing the crash resistance of Advanced High Strength Steels (AHSS). Such knowledge is essential to improve impact performance prediction and optimize new steel development. Nevertheless, there is still an open discussion about which are the most relevant properties on AHSS crashworthiness. In this work, the authors investigate the correlation between the fracture toughness of different AHSS and their crash failure behaviour. Fracture toughness is measured in the frame of fracture mechanics, through the essential work of fracture methodology. Two fracture resistance parameters are characterized: the fracture toughness at cracking initiation, wei, and the essential work of fracture, we. Toughness values are compared with the results of axial impact tests, which are evaluated according to the energy absorbed and the cracking behaviour observed in crash boxes. Results show that fracture toughness permits to describe different crash events in terms of crack initiation and crack propagation and allows ranking AHSS impact resistance; steels with higher we present better crash performance. Therefore, fracture toughness is proposed as a key material property to predict the crash resistance of AHSS and as a relevant design parameter for crash resistant parts.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Pöhls, Henrich C., et al.
(författare)
-
RERUM : Building a reliable IoT upon privacy- and security- enabled smart objects
- 2014
-
Ingår i: 2014 IEEE Wireless Communications and Networking Conference Workshops (WCNCW). - : Institute of Electrical and Electronics Engineers (IEEE). - 9781479930869 ; , s. 122-127
-
Konferensbidrag (refereegranskat)abstract
- The Internet of Things (IoT) provides a platform for the interconnection of a plethora of smart objects. It has been widely accepted for providing Information and Communication Technologies (ICT) applications in many ￜsmartￜ environments, such as cities, buildings, metering, and even agriculture. For several reasons though such applications have yet to achieve wide adoption; a major hurdle is the lack of user trust in the IoT and its role in everyday activities. RERUM, a recently started FP7 European Union project. aims to develop a framework which will allow IoT applications to consider security and privacy mechanisms early in their design phase, ensuring a configurable balance between reliability (requiring secure, trustworthy and precise data) and privacy (requiring data minimization for private information, like location). The RERUM framework will comprise an architecture, built upon novel network protocols and interfaces as well as the design of smart objects hardware. To highlight the challenges and evaluate the framework, RERUM will employ several Smart City application scenarios, which will be deployed and evaluated in real-world testbeds in two Smart Cities participating in the project. Here we detail the key technologies RERUM will investigate over the coming three years to reach its vision for IoT security, privacy and trust.
|
|
