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- Savitski, Mikhail M., et al.
(författare)
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Backbone carbonyl group basicities are related to gas-phase fragmentation of peptides and protein folding
- 2007
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 46:9, s. 1481-1484
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Tidskriftsartikel (refereegranskat)abstract
- A strong correlation is found between the propensity of individual amino acids to induce peptide-bond cleavage in the gas phase (PAA-XX) and their structure-forming propensity (PS, red) and H-bond-accepting propensity (PH, blue). Thus, the same fundamental parameter, carbonyl group basicity, governs the formation of secondary protein structures in solution and directs fragmentation in the gas phase. (Graph Presented).
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