| 1. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
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| 3. |
- Arnold, MF, et al.
(författare)
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Editorial: Does atrioventricular ring motion always distinguish constriction from restriction? A Doppler myocardial imaging study
- 2001
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Ingår i: Journal of the American Society of Echocardiography. - : Elsevier BV. - 0894-7317 .- 1097-6795. ; 14:5, s. 391-395
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Constrictive pericarditis and restrictive cardiomyopathy can be difficult to differentiate on clinical examination. Cardiac ultrasonography is increasingly being used as the noninvasive method of choice for confirming the specific morphologic and hemodynamic abnormalities associated with either condition. Interrogation of atrioventricular valve plane motion by Doppler myocardial imaging (DMI) has been suggested as a valuable new approach that can help differentiate one from the other. We report the color DMI, pulsed DMI, and strain rate findings in 2 cases of constrictive pericarditis in which consideration of the annular motion pattern alone would not have allowed such differentiation.
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| 4. |
- Berndt, Sonja, I, et al.
(författare)
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Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
- 2022
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Ingår i: Leukemia. - : Springer Nature. - 0887-6924 .- 1476-5551. ; 36:12, s. 2835-2844
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Tidskriftsartikel (refereegranskat)abstract
- Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.
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| 5. |
- Deans, Andrew R, et al.
(författare)
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Finding Our Way through Phenotypes.
- 2015
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Ingår i: PLoS Biology. - : Public Library of Science (PLoS). - 1545-7885. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility.
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| 6. |
- Escobar Kvitting, John-Peder, 1976-, et al.
(författare)
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How accurate is visual assessment of synchronicity in myocardial motion? An in vitro study with computer-simulated regional delay in myocardial motion : clinical implications for rest and stress echocardiography studies
- 1999
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Ingår i: Journal of the American Society of Echocardiography. - 0894-7317 .- 1097-6795. ; 12:9, s. 698-705
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Tidskriftsartikel (refereegranskat)abstract
- Asynchronicity in echocardiographic images is normally assessed visually. No prior quantitative studies have determined the limitations of this approach. To quantify visual recognition of myocardial asynchronicity in echocardiographic images, computer-simulated delay phantom loops were generated from a 3.3 MHz digital image data from a normal left ventricular short-axis heart cycle acquired at 55 frames per second. Six expert observers visually assessed 30 abnormal and 3 normal loops with differing computer-induced delay patterns on 3 occasions and in this optimally simulated environment could recognize only single delays of 89 ms or more. This was improved to 71 ms or more by use of side-by-side (normal versus abnormal) comparative review. Thus visual assessment of clinically important regional delay in rest or stress echo images is limited.
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| 7. |
- Escobar Kvitting, John-Peder, et al.
(författare)
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Regional asynchrony in acute ischemia and stunning : an experimental myocardial velocity and strain rate imaging study
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Objective: To quantify motion and deformation asynchrony using Doppler myocardial imaging (DMI) during acute total ischemia, and stunning of the posterior left ventricular wall (PW) in comparison with the interventricular septum (IVS).Methods: Ischemia of the PW was induced in closed-chest pigs using an angioplasty balloon positioned in the circumflex coronary artery. Animals were divided into three groups: normal controls (Group I - n = 6), total ischemia (Group II - n = 8), and stunning (Group III - n = 6) induced by coronary occlusion with distal coronary perfusion maintained via a perfusion catheter coupled to a roller pump (Group III). In addition, a 2-step dobutamine challenge (5 and 10 µg.kg-1 .min-1) was performed in groups I and III. Doppler myocardial velocity and strain rate cineloops were acquired from a parasternal short axis view.Results: The pre-ejection time (T1) and the duration of regional mechanical systole (SYS) became shorter with inotropic stimulation. During total ischemia T1 was prolonged and SYS shortened significantly compared to baseline values [62 ± 14 vs. 55 ± 13 ms (P < 0.05)], [164 ± 13 vs. 240 ± 27 ms (P < 0.001)], respectively. The fraction T1/SYS was accordingly higher. No changes were observed for the contra lateral non-ischemic wall. In group III, the post-ischemic myocardium had a similar response as non-ischemic myocardium to the dobutamine challenge.Conclusion: Consistent changes in local pre-ejection time and regional mechanical systole are induced by intropic stimulation and by total ischemia. However, the response to intropic stimulation did not differ between normal and stunned myocardium.
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| 8. |
- Escobar Kvitting, John-Peder, 1976-, et al.
(författare)
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Three-directional myocardial motion assessed using 3D phase contrast MRI
- 2004
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Ingår i: Journal of Cardiovascular Magnetic Resonance. - 1097-6647 .- 1532-429X. ; 6:3, s. 627-636
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Tidskriftsartikel (refereegranskat)abstract
- Regional myocardial function is a complex entity consisting of motion in three dimensions (3D). Besides magnetic resonance imaging (MRI), no other noninvasive technique can give a true 3D description of cardiac motion. Using a time‐resolved 3D phase contrast technique, three‐dimensional image volumes containing myocardial velocity data in six normal volunteers were acquired. Coordinates and velocity information were extracted from nine points placed in different myocardial segments in the left ventricle (LV), and decomposed into longitudinal (VL), radial (VR), and circumferential (VC) velocity components. Our findings confirm a longitudinal apex‐to‐base gradient for the LV, with only a small motion of the apex. The mean velocity for VL for all the basal segments was higher compared to the midsegments during systole [3.5 ± 1.2 vs. 2.5 ± 1.7 cm/s (p < 0.01)], early filling [− 6.9 ± 1.8 vs. − 4.9 ± 1.8 cm/s (p < 0.001)], and during atrial contraction [− 2.2 ± 1.4 vs. − 1.6 ± 1.3 cm/s (p < 0.05)]. A similar pattern was observed when comparing velocities from the midsegments to the apex. Radial velocity was higher during early filling in the midportion of the lateral [− 4.9 ± 2.7 vs. − 3.2 ± 1.6 cm/s (p < 0.05)] wall compared to the basal segments, no difference was observed for the septal [− 2.0 ± 1.5 vs. − 0.3 ± 2.5 cm/s (p = 0.15)], anterior [− 5.8 ± 3.3 vs. − 4.0 ± 1.7 cm/s (p = 0.17)], and posterior [− 2.3 ± 2.1 vs. − 2.5 ± 1.0 cm/s (p = 0.78)] walls. When observing the myocardial velocity in a single point and visualizing the movement of the main direction of the velocities in this point as vectors in velocity vector plots like planes, it is clear that myocardial movement is by no means one dimensional. In conclusion, our time‐resolved 3D, phase contrast MRI technique makes it feasible to extract myocardial velocities from anywhere in the myocardium, including all three velocity components without the need for positioning any slices at the time of acquisition.
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| 9. |
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| 10. |
- Keddy, America Cristina, et al.
(författare)
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The Team Assessment of Self-Management Support (TASMS) : A new approach to uncovering how teams support people with chronic conditions. Healthcare Management Forum
- 2021
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Ingår i: Healthcare Management Forum. - : Sage Publications. - 0840-4704 .- 2352-3883. ; 34:1, s. 43-48
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Tidskriftsartikel (refereegranskat)abstract
- Canadian and other healthcare systems are adopting primary care models founded on multidisciplinary, team-based care. This paper describes the development and use of a new tool, the Team Assessment of Self-Management Support (TASMS), designed to understand and improve the self-management support teams provide to patients with chronic conditions. Team Assessment of Self-Management Support captures the time providers spend supporting seven different types of self-management support (process strategies, resources strategies, disease controlling strategies, activities strategies, internal strategies, social interactions strategies, and healthy behaviours strategies), their referral patterns and perceived gaps in care. Four unique features make TASMS user-friendly: it is patient-centred, it uses provider-level data to create a team profile, it has the ability to be tailored to needs (diagnosis and visit type), and visual presentation of results are quickly and intuitively understood by both providers and planners. Currently being used by providers and planners in Nova Scotia, scaling up will allow more widespread use
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