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Sökning: WFRF:(Suzuki Eiichi)

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1.
  • Ishigaki, Kazuyoshi, et al. (författare)
  • Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis
  • 2022
  • Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:11, s. 1640-1651
  • Tidskriftsartikel (refereegranskat)abstract
    • Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of polygenic risk scores (PRS). Here, we present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups. We conducted a multi-ancestry meta-analysis and identified 124 loci (P < 5 × 10−8), of which 34 are novel. Candidate genes at the novel loci suggest essential roles of the immune system (for example, TNIP2 and TNFRSF11A) and joint tissues (for example, WISP1) in RA etiology. Multi-ancestry fine-mapping identified putatively causal variants with biological insights (for example, LEF1). Moreover, PRS based on multi-ancestry GWAS outperformed PRS based on single-ancestry GWAS and had comparable performance between populations of European and East Asian ancestries. Our study provides several insights into the etiology of RA and improves the genetic predictability of RA.
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2.
  • Maitani, Masato M., et al. (författare)
  • Collaborational effect of heterolytic layered configuration for enhancement of microwave heating
  • 2013
  • Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; 49:92, s. 10841-10843
  • Tidskriftsartikel (refereegranskat)abstract
    • Microwave irradiation efficiently heats up the microwave-inert materials in the range of applied frequencies when two microwave-inert materials are brought into contact in the layered configuration. This heating is applied for annealing TiO2 nanoporous films for dye-sensitized solar cells achieving a one order of magnitude more rapid annealing process for comparable performances.
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3.
  • Maitani, Masato M., et al. (författare)
  • Low-temperature annealing of mesoscopic TiO2 films by interfacial microwave heating applied to efficiency improvement of dye-sensitized solar cells
  • 2016
  • Ingår i: Solar Energy Materials and Solar Cells. - : Elsevier. - 0927-0248 .- 1879-3398. ; 147, s. 198-202
  • Tidskriftsartikel (refereegranskat)abstract
    • Novel interfacial microwave heating of a layered structure has been applied to the process of low temperature annealing of titania mesoporous films for dye-sensitized solar cells. Interfacial microwave annealing dramatically enhances the cell performances as compared with conventional heating in an electric oven. The improvement of cell performance is attributed to the electron transport properties in the titania films annealed by MW resulting in longer diffusion length as compared with conventional heating.
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  • Resultat 1-3 av 3

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