| 1. |
- Saha, Rama, et al.
(författare)
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Heritability of endometriosis
- 2015
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Ingår i: Fertility and Sterility. - : Elsevier BV. - 0015-0282 .- 1556-5653. ; 104:4, s. 947-952
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To estimate the relative contribution of genetic influences and prevalence on endometriosis.DESIGN: Analysis of self-reported data from a nationwide population-based twin registry.SETTING: Not applicable.PATIENT(S): A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998-2002 or 2005-2006).INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Self-reported endometriosis, validated by medical records.RESULT(S): A history of endometriosis was reported by 1,228 female twins. The probandwise concordance was 0.21 for MZ and 0.10 for DZ twins. Higher within-pair (tetrachoric) correlation was observed among MZ (0.47) compared with DZ (0.20) twins. The best-fitting model revealed a contribution of 47% by additive genetic factors and the remaining 53% attributed to unique environmental effects.CONCLUSION(S): Our findings suggest both genetic and unique (nonshared) environmental influences on the complex etiology of endometriosis and support the hypothesis that genes have a strong influence on phenotypic manifestations of endometriosis.
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| 2. |
- Svedberg, Lena, 1958
(författare)
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Cold feet in children with neurological disorders
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- These studies focused on presence of cold feet in children with neurological disorders and raised the questions: Does acupuncture affect skin temperature? Are cold feet a general symptom in children with neurological disorders? Are cold feet associated with other symptoms? What are the moods, health, and daily life experiences of these children’s parents? Study I assessed effects of acupuncture on skin temperature in children with neurological disorders. The study was of pilot character, to determine if further investigation in a larger, well-characterised group could be worthwhile. Study II analysed skin temperature variation between pre-school children with and without neurological disorders to determine if skin temperature and walking ability were correlated. Study III investigated accompanying symptoms, such as cold extremities, constipation, pain, sleeping disorders, and well-being, and their treatment to determine (i) whether cold extremities is a general problem, (ii) what symptom treatment the children had received, (iii) associations between cold extremities and gross-motor function, and (iv) associations between cold extremities and other symptoms borne by the child. Study IV described mood, health, and daily life experiences of the children’s parents to investigate (i) impact that the child’s impairments and symptoms have on the family and (ii) community services support. Study I (single subject design; each child was its own control) comprised 6 children with neurological disorders. Study II (hypothesis refinement study) comprised 25 healthy children recruited from a community pre-school and 15 children with cerebral or spinal cord disorders from Child and youth neurohabilitation in Örnsköldsvik. Studies III and IV (postal survey, descriptive hypothesis-generating studies) comprised 107 children with cerebral palsy (Study III) and parents of 106 of these (Study IV) from 8 habilitation centres in the northern region of Sweden. Conclusions: · Acupuncture may increase skin temperature in some children with neurological disorders and cold extremities. · Non-walking children with cerebral damage had significantly lower mean hand and foot skin temperature compared to healthy controls. · Of the 5 symptoms – cold extremities, pain, sleeping disorders, constipation, and impaired well-being – (i) most of the children with CP had had 1 or several symptoms for more than 1 year and (ii) symptom frequency was generally higher in non-walking children than in walkers. Of the children who had had symptoms for more than 1 year, a surprisingly large number had received no treatment for them. · Care-giving for a child with CP may affect parents’ moods, health, and daily living – especially if the child has several impairments and symptoms. Frequent parental anxiousness regarding the child’s physical and psychological health might be associated with affected parental health.
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| 3. |
- Svedberg, Lena, 1958, et al.
(författare)
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Comparison of impact on mood, health, and daily living experiences of primary caregivers of walking and non-walking children with cerebral palsy and provided community services support.
- 2010
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Ingår i: European journal of paediatric neurology. - : Elsevier BV. - 1532-2130 .- 1090-3798. ; 14:3, s. 239-246
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Tidskriftsartikel (refereegranskat)abstract
- Many children with cerebral palsy (CP), especially non-walkers, were previously reported to have cold extremities, pain, sleeping disorders, constipation, and impaired well-being - besides accompanying impairments. Most children had had one or more of these symptoms for more than 1 year, and the symptoms were largely untreated. This study (1) describes mood, health, and daily life experiences of the children's parents; (2) explains impact that the child's impairments and symptoms have on the family; and (3) investigates community services support. Information in this study was gathered from parents of 106 children, ages 5-16, with CP, who lived in northern Sweden. Compared with parents of walkers, parents with non-walking children and several disorders were more frequently anxious for their children's physical and psychological health; often experienced restricted time for themselves; reported frequent daily living interferences; and stated that their health was affected due to the child's health. 10 percent of all families reported that their need of community services support was unmet. To improve health and to provide good community services support for the entire family, regular follow-up and evaluation of the child's treatment and family support are important.
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| 4. |
- Svedberg, Lena, 1958, et al.
(författare)
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Parental perception of cold extremities and other accompanying symptoms in children with cerebral palsy.
- 2008
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Ingår i: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. - : Elsevier BV. - 1090-3798. ; 12:2, s. 89-96
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Tidskriftsartikel (refereegranskat)abstract
- Cold extremities have been noted in non-walking children with cerebral damage compared with healthy controls. Whether this is a general problem in children with cerebral palsy (CP) and associated with other symptoms is unknown. This study describes accompanying symptoms such as cold extremities, constipation, pain, sleeping disorders and impaired well-being in children with CP as well as treatment the children have undergone. Associations between cold extremities and other symptoms borne by the children were analysed and discussed. From information in postal surveys received from parents of children with CP, 107 children (60 boys and 47 girls) aged 5-13 years, mean 11 years 8 months (SD 2 years 11 months), were described and analysed. Besides neurological impairments, many children had cold extremities and pain, sleeping disorders, constipation, and impaired well-being. Most children had had one or more of these symptoms for over 1 year but the symptoms were largely untreated. Non-walkers generally had more symptoms than walkers. Although pain, constipation, and sleeping disorders may have different underlying causes in children with CP, these symptoms might also be mediated or aggravated by dysfunction in the autonomic nervous system. To improve the child's well-being, early recognition and treatment of accompanying symptoms is important.
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| 5. |
- Svedberg, Lena, 1958, et al.
(författare)
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Skin temperature in the extremities of healthy and neurologically impaired children.
- 2005
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Ingår i: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. - : Elsevier BV. - 1090-3798. ; 9:5, s. 347-54
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Tidskriftsartikel (refereegranskat)abstract
- Little emphasis has been accorded to peripheral skin temperature impairments in children with neurological disorders but attention has been paid to the significance of cold extremities (autonomic failure) for well-being and quality of life in adults stroke patients. Therefore, it seems important to investigate skin temperature in children with neurological disorder, especially when their communication is impaired. In the present study, we wanted to objectively verify any skin temperature differences between pre-school children with and without neurological disorders and also ascertain if any correlation existed between skin temperature and physical activity. Skin temperatures in 25 healthy children and 15 children with cerebral or spinal cord damages were assessed using infrared radiation. The temperatures were recorded on the palm and the dorsal surface of the hands and on the sole and dorsal surface of the feet three times at 15-minute intervals over 30min. A significant lower mean skin temperature in all measurement points was seen in non-walking children with cerebral damages compared to healthy controls. Also, the mean skin temperature was significantly lower in all foot measuring points in the children with cerebral damages that were unable to walk compared to those walking. In conclusion, as cold extremities may result in impaired well-being and hypothetically may be associated with other symptoms born by the child, further investigations of thermal dysfunction and autonomic function are of importance and treatment may be warranted.
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