| 1. |
- Andreasen, Laura, et al.
(författare)
-
Brugada syndrome-associated genetic loci are associated with J-point elevation and an increased risk of cardiac arrest
- 2018
-
Ingår i: Frontiers in Physiology. - : Frontiers Media SA. - 1664-042X. ; 9:JUL
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: A previous genome-wide association study found three genetic loci, rs9388451, rs10428132, and rs11708996, to increase the risk of Brugada Syndrome (BrS). Since the effect of these loci in the general population is unknown, we aimed to investigate the effect on electrocardiogram (ECG) parameters and outcomes in the general population. Materials and Methods: A cohort of 6,161 individuals (median age 45 [interquartile range (IQR) 40-50] years, 49% males), with available digital ECGs, was genotyped and subsequently followed for a median period of 13 [IQR 12.6-13.4] years. Data on outcomes were collected from Danish administrative healthcare registries. Furthermore, ~400,000 persons from UK Biobank were investigated for associations between the three loci and cardiac arrest/ventricular fibrillation (VF). Results: Homozygote carriers of the C allele in rs6800541 intronic to SCN10A had a significantly larger J-point elevation (JPE) compared with wildtype carriers (11 vs. 6 μV, P < 0.001). There was an additive effect of carrying multiple BrS-associated risk alleles with an increased JPE in lead V1. None of the BrS-associated genetic loci predisposed to syncope, atrial fibrillation, or total mortality in the general Danish population. The rs9388451 genetic locus adjacent to the HEY2 gene was associated with cardiac arrest/VF in an analysis using the UK Biobank study (odds ratio = 1.13 (95% confidence interval: 1.08-1.18), P = 0.006). Conclusions: BrS-associated risk alleles increase the JPE in lead V1 in an additive manner, but was not associated with increased mortality or syncope in the general population of Denmark. However, the HEY2 risk allele increased the risk of cardiac arrest/VF in the larger population study of UK Biobank indicating an important role of this common genetic locus.
|
|
| 2. |
- Botermans, Jos, et al.
(författare)
-
Performance, health and behaviour of organic growing-finishing pigs in two different housing systems with or without access to pasture
- 2015
-
Ingår i: Acta Agriculturae Scandinavica, Section A - Animal Science. - : Informa UK Limited. - 0906-4702 .- 1651-1972. ; 65, s. 158-167
-
Tidskriftsartikel (refereegranskat)abstract
- The effects of two housing systems (deep litter and straw-flow), with and without access to pasture during the summer period, were studied in an organic growing-finishing pig herd. Performance, health, skin lesions and daytime pig activity were studied in 29 pens of 16 pigs (total of 464 pigs, in 4 batches). Data from 21 pens were used for comparisons of deep litter and straw-flow and data from 16 pens for comparisons of access/no access to pasture. Pigs in the deep litter system had a lower carcass meat percentage (56.6% vs. 57.3%) and more locomotion problems (4.4% vs. 0%) than pigs in the straw-flow system. No difference in daytime pig activity was detected between the two housing systems. Under moderate temperatures, pigs with access to pasture and fed a commercial organic feed inside the building were not more active during daytime behaviour studies (7.30 h-16.30 h) than pigs without access to pasture. However, at 17 weeks of age the pigs with pasture access spent 21% of their time on pasture, less time inside the pig house (20% vs. 33%) and less time on the outside concrete area (4% vs. 12%) than the pigs without pasture. No difference in performance was detected between pigs with and pigs without access to pasture.
|
|
| 3. |
|
|
| 4. |
- Olsson, Anne-Charlotte, et al.
(författare)
-
An experimental model for studying claw lesions in growing female pigs
- 2016
-
Ingår i: Livestock Science. - : Elsevier BV. - 1871-1413 .- 1878-0490. ; 184, s. 58-63
-
Tidskriftsartikel (refereegranskat)abstract
- Problems with claw lesions leading to lameness are a growing concern in pig production. However, the causes and development of claw lesions are poorly understood and studies on prevention of claw lesion problems in gifts and sows are limited.This study tested a new experimental model which facilitates evaluation of the impact of different risk factors on pig feet lesions.The model consisted of using young gilts with a well-known background and promoting traumatic claw lesions for study purposes by increasing social and agonistic activity through regrouping on concrete flooring. Then claw lesions were assessed systematically and objectively on feet after slaughter. To test the model, two levels of exposure to concrete flooring were compared; normal activity in groups of gifts (no regrouping=NR) and increased activity in groups of gifts by performing several regroupings (repeated regrouping=RR).A total of 72 gilts (pairs of litter mates) in two batches, aged 4 months, were randomly distributed to the two treatments (NR and RR) in group pens (3 gilts per pen) with concrete flooring. The gilts were given approximately 200 g of straw per gilt every day. At 8, 9 and 10 months of age, half the gilts (36 animals) were regrouped with each other. At 11 months of age, all gifts in both treatments were slaughtered and the left rear foot from each was removed and collected for detailed studies of claw lesions. Lesions of the heel, transition heel/toe, white line, wall and toe and over-growth of the heel were assessed on the outer and inner digit. Blind scoring of claw lesions on a scale from 0 to 3 was carried out in laboratory conditions on cleaned claws. Body lesions were also blind-scored on a scale from 0 to 3 one week after the third regrouping.The results showed claw lesions on the soft and hard horn of the claws and significantly (p = 0.004) higher claw lesion score in RR gifts (0.40) than in NR gilts (0.23).It was concluded that as expected, regrouping gifts on concrete flooring resulted in both more numerous and more severe claw lesions than ungrouped gilts. Likewise, body lesion score was significantly (p < 0.001) higher in RR gilts (1.71) than NR gilts (0.46).It was also concluded that the proposed model could be a successful experimental design for challenging different risk factors, e.g. flooring and management, for development of claw lesions in pigs. (C) 2015 Elsevier B.V. All rights reserved.
|
|
| 5. |
- Olsson, Anne-Charlotte, et al.
(författare)
-
Animal interaction and response to electronic sow feeding (ESF) in 3 different herds and effects of function settings to increase capacity
- 2011
-
Ingår i: Livestock Science. - : Elsevier BV. - 1871-1413 .- 1878-0490. ; 137, s. 268-272
-
Tidskriftsartikel (refereegranskat)abstract
- ESF feeding technology is one of the available choices for the group housing of gestating sows. The general objective of this investigation was to study animal interaction and response to ESF feeding in 3 sow herds. The focus was on the effect of the EFS settings used to determine feeder capacity (feed delivery intervals, amount to be delivered, gate management), on animal interactions and attacks at the feeder, and on the occurrence of vulva lesions and skin injuries. More than 50 % of the sow visits to the feeder were non-feeding visits, and sows attacking a sow when she entered the feeder were noted in one third of the visits. When changing sows in the feeder, 4-6 sows queued at the entrance gate; it was found that one third of these had eaten previously. Vulva bites were seen in up to one third of the sows; many of these bites were serious, bleeding lesions. Feeder settings which increased the capacity, thus shortening the available feeding time, also resulted in significantly more sow queuing. In addition, the presence of serious vulva bites was more pronounced in the herd with the highest capacity settings. An increase in feed spillage and the presence of unusual bite lesions at the root of the tail were also attributed to settings for higher capacity (shorter available eating times). It was concluded that the biological function (how sows relate to the system) depended very much on the feeder settings
|
|
| 6. |
|
|
| 7. |
- Olsson, Anne-Charlotte, et al.
(författare)
-
Klövskador hos suggor : en pilotstudie för att öka förståelsen av hur skadorna uppkommer
- 2011
-
Ingår i: LTJ-fakultetens faktablad.
-
Annan publikation (populärvet., debatt m.m.)abstract
- Klövskador hos suggor under sinperioden är ett växande bekymmer. Klövskador orsakar lidande för djuren och leder ofta till för tidig utslagning eftersom djurens produktion påverkas negativt. Att hålla suggorna lösgående i grupp jämfört med att ha suggorna fixerade ökar problemen. I denna pilotstudie har klövskador hos gyltor som omgrupperats vid tre tillfällen under tillväxten jämförts med klövskador hos gyltor som under tillväxten hållits i intakta grupper. Det utförda pilotförsöket visar tydligt på att en ökad aktivitet hos djuren i form av konflikter i samband med omgrupperingar, förutom fler bit- och rivskador också ger upphov till fler klövskador på djuren. De hittills erhållna resultaten är mycket intressanta och visar på att konflikter och annat aggressivt beteende, som ses bl a i samband med blandningar av djur, kan vara en starkt bidragande orsak till en hög förekomst av klövskador. Detta har inte dokumenterats tidigare. Omgrupperingar av djur kan användas som ”modell” för att öka belastningen på klövarna. En sådan ”modell” bör med framgång kunna användas i samband med tester av närmiljödetaljer (golvmaterial o d) som bedöms kunna ge mindre slitage på klövarna och en långsiktigt förbättrad klövhälsa hos våra suggor.
|
|
| 8. |
- Olsson, Anne-Charlotte, et al.
(författare)
-
Pen hygiene, N, P and K budgets and calculated nitrogen emission for organic growing-finishing pigs in two different housing systems with and without pasture access
- 2014
-
Ingår i: Livestock Science. - : Elsevier BV. - 1871-1413 .- 1878-0490. ; 165, s. 138-146
-
Tidskriftsartikel (refereegranskat)abstract
- The effects of two housing systems (deep litter and straw-flow), with and without access to pasture during the summer period, were studied in an organic growing-finishing pig herd. Pen hygiene studies, N, P and K budgets and estimations of nitrogen emission were made for two batches (8 pens/batch and 16 pigs/pen) one during the winter period and one during the summer period. It was concluded that there were no significant differences in overall pen hygiene between the housing systems. During the growing period in the summer, the pen hygiene on the outdoor concrete area was significantly better (P < 0.05) when the pigs had access to pasture. In addition, the total pen hygiene (indoors+concrete area outdoors) tended (P=0.09) to be cleaner with access to pasture during the summer period. The N-losses of the amount of N excreted were the same (26-27%) during the winter period as during the summer period. The amount of N excreted was on average 6.0 kg N per pig during the winter, and 4.2 kg N per pig during the summer; this was equivalent to an N-emission of 1.5-1.6 kg N/pig during winter and 1.1-1.2 kg N/pig during summer. The difference was mainly due to a higher feed consumption and more straw usage during the winter. In comparison to the calculated N-emissions from a non-organic pig, this was approximately 3-4 times greater. In the present study, a 10% larger feed usage explained the differences in N-emission by a factor of 1.2, a 15% higher crude protein level explained the differences by a factor of 1.3 and finally a larger fouled area explained the differences by a factor of 2.3. Differences in temperature and airflow were not taken into account in these calculations. (C) 2014 Elsevier B.V. All rights reserved.
|
|
| 9. |
|
|
| 10. |
|
|
