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Sökning: WFRF:(Svenningsen N)

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  • Bjerre, I, et al. (författare)
  • Monitoring of cerebral function after severe asphyxia in infancy
  • 1983
  • Ingår i: Archives of Disease in Childhood. - 1468-2044. ; 58:12, s. 997-1002
  • Tidskriftsartikel (refereegranskat)abstract
    • Thirty nine infants with severe asphyxia (28 affected perinatally and 11 later) were studied by electrophysiological cerebral function monitoring (CFM) for periods varying from a half to 49 days. Nineteen infants died while still in intensive care and two died later from sequelae. Eighteen survived and were followed up when aged between 8 and 36 months. The initial electroencephalogram (EEG) and the first 12 hours of CFM tracing correlated well. The type of background activity, whether continuous or interrupted, proved to be of high prognostic importance unlike the presence of seizure activity, which bore no distinct correlation to outcome in these severely asphyxiated infants.
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  • Feet, B A, et al. (författare)
  • Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets
  • 1998
  • Ingår i: Journal of Applied Physiology. - 1522-1601. ; 84:4, s. 1208-1216
  • Tidskriftsartikel (refereegranskat)abstract
    • We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were found among the groups. BE and plasma hypoxanthine, however, normalized significantly more slowly during controlled hypoxemic resuscitation than during resuscitation with 21 or 100% O2. We conclude that early brain recovery during controlled hypoxemic resuscitation was as efficient as, but not superior to, recovery during resuscitation with 21 or 100% O2. The systemic metabolic recovery from hypoxia, however, was delayed during controlled hypoxemic resuscitation.
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  • Greisen, G, et al. (författare)
  • EEG depression and germinal layer haemorrhage in the newborn
  • 1987
  • Ingår i: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 76:3, s. 519-525
  • Tidskriftsartikel (refereegranskat)abstract
    • Amplitude integrated EEG (aEEG) recordings from 32 mechanically ventilated infants, gestational age 32 weeks or less, were analysed. All recordings were started within 24 h of birth and continued for at least 50 h. Germinal layer haemorrhage (GLH) was diagnosed by repeated ultrasonography. In six infants neither GLH nor hypocalcaemia were diagnosed; aEEG in these infants rapidly became more active after birth: at 30 h of age continuous background activity was present for more than 20% of the time, and a seizure-like pattern was exceptional. In seven infants without GLH but with hypocalcaemia and other signs of metabolic derangement, continuous background activity appeared later and seizure-like activity was frequent. In the infants with GLH, depression of the background activity was apparent. This finding was particularly distinct in the presence of severe haemorrhages. Four infants developed GLH after 30 h of age. All these infants had depressed aEEG before the development of GLH, with less than 20% continuous activity at 30 h of age. In ten infants an analysis of the aEEG during the occurrence of GLH was possible. In six of these, cortical electrical activity decreased. Due to the limitation of GLH timing, it was not possible to decide whether this decrease closely preceded or followed GLH. We suggest that GLH primarily occurs in brains with a preceding metabolic and neurophysiologic abnormality, and that further functional deterioration is caused by the most severe haemorrhages.
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  • Hellström-Westas, Lena, et al. (författare)
  • Cerebral complications detected by EEG-monitoring during neonatal intensive care
  • 1989
  • Ingår i: Acta paediatrica Scandinavica. Supplement. - : Wiley. - 0300-8843. ; 78:S360, s. 83-86
  • Tidskriftsartikel (refereegranskat)abstract
    • The report describes the clinical use and value of continuous EEG-monitoring during different clinical circumstances that are not usually related to changes in EEG. Three infants with pneumothorax, hypoglycaemia, and severe hyaline membrane, respectively, are presented.
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