| 1. |
- Svensson, Per Anders, 1959, et al.
(författare)
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Identification of genes predominantly expressed in human macrophages
- 2004
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Ingår i: Atherosclerosis. - : Elsevier BV. ; 177, s. 287-290
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Tidskriftsartikel (refereegranskat)abstract
- Identification of cell and tissue specific genes may provide novel insights to signaling systems and functions. Macrophages play a key role in many diseases including atherosclerosis. Using DNA microarrays we compared the expression of approximately 10,000 genes in 56 human tissues and identified 23 genes with predominant expression in macrophages. The identified genes include both genes known to be macrophage specific and genes previously not well described in this cell type. Tissue distribution of two genes, liver X receptor (LXR) alpha and interleukin-1 receptor antagonist (IL1RN), was verified by real-time RT-PCR. We conclude that comparison of expression profiles from a large number of tissues can be used to identify genes that are predominantly expressed in certain tissues. Identification of novel macrophage specific genes may increase our understanding of the role of this cell in different diseases.
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| 2. |
- Svensson, Per-Arne, 1969, et al.
(författare)
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Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic plaques
- 2005
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Ingår i: BMC Cardiovasc Disord. - : Springer Science and Business Media LLC. - 1471-2261. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The protective role of high-density lipoprotein (HDL) in the cardiovascular system is related to its role in the reverse transport of cholesterol from the arterial wall to the liver for subsequent excretion via the bile. Scavenger receptor class B type I (SR-BI) binds HDL and mediates selective uptake of cholesterol ester and cellular efflux of cholesterol to HDL. The role of SR-BI in atherosclerosis has been well established in murine models but it remains unclear whether SR-BI plays an equally important role in atherosclerosis in humans. The aim of this study was to investigate the expression of SR-BI and its isoforms in human macrophages and atherosclerotic plaques. METHODS: The effect of hypoxia and minimally modified low-density lipoprotein (mmLDL), two proatherogenic stimuli, on SR-BI expression was studied in human monocyte-derived macrophages from healthy subjects using real-time PCR. In addition, SR-BI expression was determined in macrophages obtained from subjects with atherosclerosis (n = 15) and healthy controls (n = 15). Expression of SR-BI isoforms was characterized in human atherosclerotic plaques and macrophages using RT-PCR and DNA sequencing. RESULTS: SR-BI expression was decreased in macrophages after hypoxia (p < 0.005). In contrast, SR-BI expression was increased by exposure to mmLDL (p < 0.05). There was no difference in SR-BI expression in macrophages from patients with atherosclerosis compared to controls. In both groups, SR-BI expression was increased by exposure to mmLDL (p < 0.05). Transcripts corresponding to SR-BI and SR-BII were detected in macrophages. In addition, a third isoform, referred to as SR-BIII, was discovered. All three isoforms were also expressed in human atherosclerotic plaque. Compared to the other isoforms, the novel SR-BIII isoform was predicted to have a unique intracellular C-terminal domain containing 53 amino acids. CONCLUSION: We conclude that SR-BI is regulated by proatherogenic stimuli in humans. However, we found no differences between subjects with atherosclerosis and healthy controls. This indicates that altered SR-BI expression is not a common cause of atherosclerosis. In addition, we identified SR-BIII as a novel isoform expressed in human macrophages and in human atherosclerotic plaques.
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| 3. |
- Alam, Ashraful, et al.
(författare)
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Parallelization of the Estimation Algorithm of the 3D Structure Tensor
- 2012
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Ingår i: 2012 International Conference on Reconfigurable Computing and FPGAs, ReConFig 2012. - Piscataway, N.J. : IEEE Press. - 9781467329194 - 9781467329217
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Konferensbidrag (refereegranskat)abstract
- The three dimensional structure tensor algorithm (3D-STA) is often used in image processing applications to compute the optical flow or to detect local 3D structures and their directions. This algorithm is computationally expensive due to many computations that are required to calculate the gradient, the tensor, and to smooth every pixel of the image frames. Therefore, it is important to parallelize the implementation to achieve high performance. In this paper we present two parallel implementations of 3D-STA; namely moderately parallelized and highly parallelized implementation, on a massively parallel reconfigurable array. Finally, we evaluate the performance of the generated code and results are compared with another optical flow implementation. The throughput achieved by the moderately parallelized implementation is approximately half of the throughput of the Optical flow implementation, whereas the highly parallelized implementation results in a 2x gain in throughput as compared to the optical flow implementation. © 2012 IEEE.
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| 4. |
- Almén, Oscar, 1970-, et al.
(författare)
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Kina idag
- 2008
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Bok (populärvet., debatt m.m.)
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| 5. |
- Almgren Mason, Suzanne, et al.
(författare)
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Bridging Scientific Cultures in a Regional Health Care Context
- 2010
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Ingår i: VIII Triple Helix International Conference on University, Industry and Government Linkages.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Embedded Intelligent Systems (EIS) is the joint research field of the four collaborating laboratories at the School of Information Science, Computer and Electrical Engineering (IDE) at Halmstad University. The research of the four labs is integrated into a strong concerted research environment within embedded systems (EIS) - with a perspective reaching from the enabling technology via new system solutions and intelligent applications to end user aspects and business models. It is an expanding research area with many applications, not least ones that exist in everyday life.EIS is an important research environment contributing to the regional Triple Helix innovation system Healthcare Technology which the region has pointed out as a prioritised development sector. With its strong connections to both established and new, expanding firms hived off from the university, the research environment is active in the Healthcare Technology Alliance, a network of around sixty companies, counties and health care providers in south-western Sweden with the aim of developing the region into a leading arena for the development of health technology products and services. Several projects together with these participants concern both research and technology transfer.An integrated gender and gender equality perspective in innovations within the health technology area is necessary in order to be able to meet the needs of an ageing population with quality innovations. The relevancy of a gender perspective is clear in relation to the fact that about 70% of all those older than 75 years are women. Older women are on average cared for in hospital twice as long as men, partly due to differing disease panoramas, but also because men are more often cared for in the home by a woman while the women who live longer more often live alone. With the expansion of home-help and home nursing new needs follow and it is likely that a gender perspective will become necessary for the development of products and services that can make daily life easier for the elderly. The gender perspective also has relevance from the point of view of care staff. New technology is developed for application within the health and care sector where the larger professional groups consist mainly of women. The technology, most often designed by men, is used by women. With this in mind it is clear that an important aspect of good innovations is that the end users are involved in the innovation process.Based on an awareness of the need for a more articulated gender perspective within the research environment, in order to meet the needs expressed above, an application for a gender inclusive R&D project was handed in to the VINNOVA programme Applied Gender Research in Strong Research and Innovation Environments. The G-EIS project (Gender Perspective on Embedded Intelligent Systems - Application in Healthcare Technology) was approved and started in 2009. The project involves researchers from the EIS research environment as well as representatives from companies and the public sector.The project participants are on the whole agreed on the need for a gender perspective in the R&I environment, but struggle with the meeting of two epistemologically opposed theories of science. The understanding within gender studies that research and production both create reality and are informed by it is not always accepted within the areas of natural science. Engineering and other technological sciences not only consider aspects of science to be separate from reality, but also seek positivistic proof in research, something not always possible in the more qualitative research of the social sciences. Researching how these two perspectives meet within this specific project is the topic of this paper.
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| 6. |
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| 7. |
- Bengtsson, Jerker, et al.
(författare)
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A configurable framework for stream programming exploration in baseband applications
- 2006
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Ingår i: 2006 IEEE International Parallel & Distributed Processing Symposium. - Piscataway, N.J. : IEEE Press. - 1424400546 ; , s. 8-
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Konferensbidrag (refereegranskat)abstract
- This paper presents a configurable framework to be used for rapid prototyping of stream based languages. The framework is based on a set of design patterns defining the elementary structure of a domain specific language for high-performance signal processing. A stream language prototype for baseband processing has been implemented using the framework. We introduce language constructs to efficiently handle dynamic reconfiguration of distributed processing parameters. It is also demonstrated how new language specific primitive data types and operators can be used to efficiently and machine independently express computations on bitfields and data-parallel vectors. These types and operators yield code that is readable, compact and amenable to a stricter type checking than is common practice. They make it possible for a programmer to explicitly express parallelism to be exploited by a compiler. In short, they provide a programming style that is less error prone and has the potential to lead to more efficient implementations.
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| 8. |
- Bengtsson, Jerker, et al.
(författare)
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A Domain-specific Approach for Software Development on Manycore Platforms
- 2008
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Ingår i: SIGARCH Computer Architecture News. - New York : ACM Press. - 0163-5964 .- 1943-5851. ; 36:5, s. 2-10
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Tidskriftsartikel (refereegranskat)abstract
- The programming complexity of increasingly parallel processors calls for new tools that assist programmers in utilising the parallel hardware resources. In this paper we present a set of models that we have developed as part of a tool for mapping dataflow graphs onto manycores. One of the models captures the essentials of manycores identified as suitable for signal processing, and which we use as target for our algorithms. As an intermediate representation we introduce timed configuration graphs, which describe the mapping of a model of an application onto a machine model. Moreover, we show how a timed configuration graph by very simple means can be evaluated using an abstract interpretation to obtain performance feedback. This information can be used by our tool and by the programmer in order to discover improved mappings.
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| 9. |
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| 10. |
- Bengtsson, Jerker, et al.
(författare)
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Manycore performance analysis using timed configuration graphs
- 2009
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Ingår i: International Symposium on Systems, Architectures, Modeling, and Simulation, 2009. SAMOS '09. - Piscataway, N.J. : IEEE Press. - 9781424445028 ; , s. 108-117
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Konferensbidrag (refereegranskat)abstract
- The programming complexity of increasingly parallel processors calls for new tools to assist programmers in utilising the parallel hardware resources. In this paper we present a set of models that we have developed to form part of a tool which is intended for iteratively tuning the mapping of dataflow graphs onto manycores. One of the models is used for capturing the essentials of manycores that are identified as suitable for signal processing and which we use as target architectures. Another model is the intermediate representation in the form of a timed configuration graph, describing the mapping of a dataflow graph onto a machine model. Moreover, this IR can be used for performance evaluation using abstract interpretation. We demonstrate how the models can be configured and applied in order to map applications on the Raw processor. Furthermore, we report promising results on the accuracy of performance predictions produced by our tool. It is also demonstrated that the tool can be used to rank different mappings with respect to optimisation on throughput and end-to-end latency.
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