| 1. |
- Bohlooly-Yeganeh, Mohammad, 1966, et al.
(författare)
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Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.
- 2005
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Ingår i: Diabetes. - 0012-1797 .- 1939-327X. ; 54:1, s. 51-62
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Tidskriftsartikel (refereegranskat)abstract
- It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nervous system (CNS) were created to investigate the role of GH in CNS. This study shows that overexpression of GH in the CNS differentiates the effect of GH on body fat mass from that on appetite. The transgenic mice were not GH-deficient but were obese and showed increased food intake as well as increased hypothalamic expression of agouti-related protein and neuropeptide Y. GH also had an acute effect on food intake following intracerebroventricular injection of C57BL/6 mice. The transgenic mice were severely hyperinsulinemic and showed a marked hyperplasia of the islets of Langerhans. In addition, the transgenic mice displayed alterations in serum lipid and lipoprotein levels and hepatic gene expression. In conclusion, GH overexpression in the CNS results in hyperphagia-induced obesity indicating a dual effect of GH with a central stimulation of appetite and a peripheral lipolytic effect.
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| 2. |
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| 3. |
- Johnsson, Filip, 1960, et al.
(författare)
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Fluidization regimes in boilers
- 1995
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Ingår i: Preprints of Fluidization VIII. ; , s. 129-136
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The fluid dynamics were studied in a fluidized bed boiler and in two laboratory fluidized beds under ambient conditions. The beds had different geometries but were all of a non-slugging type operated with Geldart Group B and D particles. The bed geometry was found to strongly influence the fluid dynamics of the bed.
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| 4. |
- Johnsson, Filip, 1960, et al.
(författare)
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Fluidization regimes in fluidized bed boilers
- 1992
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Ingår i: Proc of the 7th Engineering Foundation Conference on Fluidization. - 0939204479 ; 7, s. 471-478
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Konferensbidrag (refereegranskat)abstract
- The fluidization regime of the bottom bed has been investigated in a circulating fluidized bed at ambient temperature. A few measurements have also been made in a 12 MWth CFB boiler at normal operation temperature. It was found that the bottom bed was of a bubbling type for all conditions studied.
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| 5. |
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| 6. |
- Svensson, Anders, 1960, et al.
(författare)
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Bottom bed regimes in a circulating fluidized bed boiler
- 1996
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Ingår i: International Journal of Multiphase Flow. - 0301-9322. ; 22:6, s. 1187-1204
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Tidskriftsartikel (refereegranskat)abstract
- This paper extends previous work on the fluidization regimes of the bottom bed of circulating flyidized bed (CFB) boilers. Pressure measurements were performed to obtain the time-average bottom bed voidage and to study the bed pressure fluctuations. The measurements were carried out in a 12 MWth CFB boiler operated at 850°C and also under ambient conditions (40°C). Two bubbling regimes were identified: a “single bubble regime” with large single bubbles present at low fluidization velocities, and, at high fluidization velocities, an “exploding bubble regime” with bubbles often stretching all the way from the air distributor to the surface of the bottom bed. The exploding bubble regime results in a high through-flow of gas, indirectly seen from the low average voidage of the bottom bed, which is similar to that of a stationary fluidized bed boiler, despite the higher gas velocities in the CFB boiler. Methods to determine the fluidization velocity at the transition from the single to the exploding bubble regime are proposed and discussed. The transition velocity increases with an increase in particle size and bed height.
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| 7. |
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| 8. |
- Svensson, Anders, 1960, et al.
(författare)
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Fluidization regimes in non-slugging fluidized beds: the influence of pressure drop across the air distributor
- 1996
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Ingår i: Powder Technology. - 1873-328X .- 0032-5910. ; 86:3, s. 299-312
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the present work is to study the influence of the pressure drop across the air distributor on the bubbling conditions of thebottom bed of circulating fluidized beds (CFB). The bottom bed is the dense bubbling zone just above the distributor. The experimental workwas carried out in a 12 MWm CFB boiler and in a cold CFR Three different distributions of the bubble flow in time and space, termedfluidization regimes, were identified in the cold CFB: the multiple bubble regime with many small bubbles evenly distributed in the bed; thesingle bubble regime, characterized by the presence of only one bubble at a time in the bed; and the exploding bubble regime with large,single, irregular voids stretching from the air distributor to the bed surface. These bubbling conditions were observed during variations in thegas velocity and the distributor pressure drop. A comparison with the 2 mz cross-section CFB boiler showed that the boiler always operatesin the single or in the exploding bubble regime, which indicates a bubble flow that is not continuous and not well distributed over the crosssectionof the bed. The conditions in the boiler are influenced by the relatively large area of gas passage and the low pressure drop of theboiler air distributor.
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| 9. |
- Aifa, Sami, et al.
(författare)
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Interactions between the juxtamembrane domain of the EGFR and calmodulin measured by surface plasmon resonance
- 2002
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Ingår i: Cellular Signalling. - 0898-6568 .- 1873-3913. ; 14:12, s. 1005-1013
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Tidskriftsartikel (refereegranskat)abstract
- One early response to epidermal growth factor receptor (EGFR) activation is an increase in intracellular calcium. We have used surface plasmon resonance (SPR) to study real-time interactions between the intracellular juxtamembrane (JM) region of EGFR and calmodulin. The EGFR-JM (Met644-Phe688) was expressed as a GST fusion protein and immobilised on a sensor chip surface. Calmodulin specifically interacts with EGFR-JM in a calcium-dependent manner with a high on and high off rate. Chemical modification of EGFR-JM by using arginine-selective phenylglyoxal or deletion of the basic segment Arg645-Arg657 inhibits the interaction. Phosphorylation of EGFR-JM by protein kinase C (PKC) or glutamate substitution of Thr654 inhibits the interaction, suggesting that PKC phosphorylation electrostatically interferes with calmodulin binding to basic arginine residues. Calmodulin binding was also inhibited by suramin. Our results suggest that EGFR-JM is essential for epidermal growth factor (EGF)-mediated calcium-calmodulin signalling and for signal integration between other signalling pathways.
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| 10. |
- Alirani, Gertrud, 1976-
(författare)
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Miljöintegrering i praktisk tillämpning : En policystudie av två lokala stadsutvecklingsprocesser
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Dealing with environmental problems has become one of the most challenging political issues of our time. Since the Brundtland report in 1987, environmental policy integration (EPI) that is, the mainstreaming of environmental issues in all policy sectors has emerged as a viable policy solution. This has meant that responsibility for implementing environmental policy rests to a large extent on local authorities where environmental problems with both local and global consequences are expected to be handled. However, there is still a disagreement on what EPI means in day-to-day decision making. With a theoretical framework drawing from theory on policy change, policy entrepreneurship and the neoinstitutional “logic of appropriateness” the aim of this dissertation is to analyze how the integration of environmental considerations manifests itself in local policy processes, highlighting what factors foster or hinder EPI. To reach this aim, I have followed two urban development processes in Kristianstad. This research offers insights on how EPI varies through the policy process and how focus is placed mainly on certain environmental issues and chiefly defined as of local importance. My study suggest that arenas for coordination are critical to overcoming the perceived “gap” between EPI on a strategic level and its implementation. This can help to clarify responsibility allocation among bureaucrats and their leeway for interpretation when new issues comes up continuously during the processes and affect the conditions for EPI. Furthermore, the dissertation gives insights on how acting “entrepreneurially” can enable an environmental issue to be included and given priority. This can also be a barrier if the ones acting entrepreneurially are not part of the entire process because the issue might receive less attention. In addition, if too much attention is given to one issue it might overshadow other environmental issues. Conversely, acting according to “the logic of appropriateness” can enable EPI by enhancing a more all-encompassing perspective on environmental considerations and also function as a cautious approach to radical change by preventing measures taken in absence of democratic legitimacy. By using the two theoretical perspectives, “entrepreneurial” and “appropriate” agency, this dissertation offers important insights into how different ways of acting interact and affect EPI and its outcome.
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