| 1. |
- Bruzzi, M, et al.
(författare)
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Radiation-hard semiconductor detectors for SuperLHC
- 2005
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 541:1-2, s. 189-201
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Tidskriftsartikel (refereegranskat)abstract
- An option of increasing the luminosity of the Large Hadron Collider (LHC) at CERN to 1035 cm-2 s-1 has been envisaged to extend the physics reach of the machine. An efficient tracking down to a few centimetres from the interaction point will be required to exploit the physics potential of the upgraded LHC. As a consequence, the semiconductor detectors close to the interaction region will receive severe doses of fast hadron irradiation and the inner tracker detectors will need to survive fast hadron fluences of up to above 1016cm-2. The CERN-RD50 project "Development of Radiation Hard Semiconductor Devices for Very High Luminosity Colliders" has been established in 2002 to explore detector materials and technologies that will allow to operate devices up to, or beyond, this limit. The strategies followed by RD50 to enhance the radiation tolerance include the development of new or defect engineered detector materials (SiC, GaN, Czochralski and epitaxial silicon, oxygen enriched Float Zone silicon), the improvement of present detector designs and the understanding of the microscopic defects causing the degradation of the irradiated detectors. The latest advancements within the RD50 collaboration on radiation hard semiconductor detectors will be reviewed and discussed in this work.
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| 2. |
- Brante, Thomas, et al.
(författare)
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Inledning
- 2019
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Ingår i: Det professionella landskapets framväxt. - 9789144122052 ; , s. 17-54
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Bokkapitel (refereegranskat)
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| 3. |
- Svensson, Kerstin, et al.
(författare)
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Det svenska professionella landskapet
- 2019
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Ingår i: Ett professionellt landskap i förvandling. - 9789144122274 ; , s. 15-60
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Bokkapitel (refereegranskat)
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| 4. |
- Johnsson, Eva, et al.
(författare)
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Den psykosociala integrationens fält.
- 2019
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Ingår i: Det professionella landskapets framväxt. - 9789144122052 ; , s. 261-331
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Svensson, Lennart, et al.
(författare)
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Psykosociala integrationens fält i nutid
- 2019
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Ingår i: Ett professionellt landskap i förvandling. - 9789144122274 ; , s. 217-271
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Svensson, Kerstin, et al.
(författare)
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Den sociala regleringens fält
- 2019
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Ingår i: Det professionella landskapets framväxt. - 9789144122052 ; , s. 209-260
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Svensson, Kerstin, et al.
(författare)
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Den sociala regleringens professioner
- 2019
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Ingår i: Ett professionellt landskap i förvandling. - 9789144122274 ; , s. 171-216
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Ahlberg, Erik, et al.
(författare)
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"Vi klimatforskare stödjer Greta och skolungdomarna"
- 2019
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Ingår i: Dagens nyheter (DN debatt). - 1101-2447.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- DN DEBATT 15/3. Sedan industrialiseringens början har vi använt omkring fyra femtedelar av den mängd fossilt kol som får förbrännas för att vi ska klara Parisavtalet. Vi har bara en femtedel kvar och det är bråttom att kraftigt reducera utsläppen. Det har Greta Thunberg och de strejkande ungdomarna förstått. Därför stödjer vi deras krav, skriver 270 klimatforskare.
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| 9. |
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| 10. |
- Douagi, I., et al.
(författare)
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Role of interferon regulatory factor 3 in type I interferon responses in rotavirus-infected dendritic cells and fibroblasts
- 2007
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Ingår i: Journal of Virology. - 0022-538X .- 1098-5514. ; 81:6, s. 2758-2768
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Tidskriftsartikel (refereegranskat)abstract
- The main pathway for the induction of type I interferons (IFN) by viruses is through the recognition of viral RNA by cytosolic receptors and the subsequent activation of interferon regulatory factor 3 (IRF-3), which drives IFN-a/ß transcription. In addition to their role in inducing an antiviral state, type I IFN also play a role in modulating adaptive immune responses, in part via their effects on dendritic cells (DCs). Many viruses have evolved mechanisms to interfere with type I IFN induction, and one recently reported strategy for achieving this is by targeting IRF-3 for degradation, as shown for rotavirus nonstructural protein 1 (NSP1). It was therefore of interest to investigate whether rotavirus-exposed DCs would produce type I IFN and/or mature in response to the virus. Our results demonstrate that IRF-3 was rapidly degraded in rotavirus-infected mouse embryonic fibroblasts (MEFs) and type I IFN was not detected in these cultures. In contrast, rotavirus induced type I IFN production in myeloid DCs (mDCs), resulting in their activation. Type I IFN induction in response to rotavirus was reduced in mDCs from IRF-3-/- mice, indicating that IRF-3 was important for mediating the response. Exposure of mDCs to UV-treated rotavirus induced significantly higher type I IFN levels, suggesting that rotavirus-encoded functions also antagonized the response in DCs. However, in contrast to MEFs, this action was not sufficient to completely abrogate type I IFN induction, consistent with a role for DCs as sentinels for virus infection. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
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