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- Bouyoucef, S E, et al.
(författare)
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Poster Session 2 : Monday 4 May 2015, 08
- 2015
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Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Fodor, G., et al.
(författare)
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An Overview of Device-to-Device Communications Technology Components in METIS
- 2016
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Ingår i: IEEE Access. - : Institute of Electrical and Electronics Engineers (IEEE). - 2169-3536 .- 2169-3536. ; 4, s. 3288-3299
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Tidskriftsartikel (refereegranskat)abstract
- As the standardization of network-assisted device-to-device (D2D) communications by the Third Generation Partnership Project progresses, the research community has started to explore the technology potential of new advanced features that will largely impact the performance of 5G networks. For 5G, D2D is becoming an integrative term of emerging technologies that take an advantage of the proximity of communicating entities in licensed and unlicensed spectra. The European 5G research project Mobile and Wireless Communication Enablers for the 2020 Information Society (METIS) has identified advanced D2D as a key enabler for a variety of 5G services, including cellular coverage extension, social proximity, and communicating vehicles. In this paper, we review the METIS D2D technology components in three key areas of proximal communications-network-assisted multi-hop, full-duplex, and multi-antenna D2D communications-and argue that the advantages of properly combining cellular and ad hoc technologies help to meet the challenges of the information society beyond 2020.
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| 4. |
- Sakellariou, P., et al.
(författare)
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Chronic L-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regime for combating obesity and improving metabolic health
- 2016
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Ingår i: Medical Hypotheses. - : Elsevier BV. - 0306-9877. ; 93, s. 21-26
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Obesity constitutes a serious global health concern reaching pandemic prevalence rates. The existence of functional brown adipose tissue (BAT) in adult humans has provoked intense research interest in the role of this metabolically active tissue in whole-body energy balance and body weight regulation. A number of environmental, physiological, pathological, and pharmacological stimuli have been proposed to induce BAT-mediated thermogenesis and functional thermogenic BAT-like activity in white adipose tissue (WAT), opening new avenues for therapeutic strategies based on enhancing the number of beige adipocytes in WAT. Hypothesis: Recent evidence support a role of L-menthol cooling, mediated by TRPM8 receptor, on UCP1-dependent thermogenesis and BAT-like activity in classical WAT depots along with the recruitment of BAT at specific anatomical sites. L-Menthol-induced BAT thermogenesis has been suggested to occur by a beta-adrenergic-independent mechanism, avoiding potential side-effects due to extensive beta-adrenergic stimulation mediated by available beta receptor agonists. L-Menthol has been also linked to the activation of the cold-gated ion channel TRPA1. However, its role in L-menthol-induced UCP1-dependent thermogenic activity in BAT and WAT remains undetermined. White adipose tissue plasticity has important clinical implications for obesity prevention and/or treatment because higher levels of UCP1-dependent thermogenesis can lead to enhanced energy expenditure at a considerable extent. We hypothesize that chronic dietary L-menthol treatment could induce TRPM8- and TRPA1-dependent WAT adaptations, resembling BAT-like activity, and overall improve whole-body metabolic health in obese and overweight individuals. Conclusions: The putative impact of chronic L-menthol dietary treatment on the stimulation of BAT-like activity in classical WAT depots in humans remains unknown. A detailed experimental design has been proposed to investigate the hypothesized L-menthol-induced browning of WAT. If our hypothesis was to be confirmed, TRPM8/TRPA1-induced metabolic adaptations of WAT to BAT-like activity could provide a promising novel therapeutic approach for increasing energy expenditure, regulating body weight, and preventing obesity and its related co-morbidities in humans. (C) 2016 Elsevier Ltd. All rights reserved.
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