| 1. |
- Hedblom, Marcus, et al.
(författare)
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Metoder och möjligheter att använda NILS data i tillämpad integrerad landskapsplanering: Renbruksplaner, UAV låghöjdsflygfotografier och dialog Methods and possibilities to apply NILS data for applied integrated landscape planning: Reindeer Husbandry Plans, UAV low altitude aerial photos and dialogue
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Summary There is a need for more integrated landscape planning due to rapid changes in landscape use through increased rationalization of land use (e.g. forestry), climate change and lack of planning in the landscape outside the cities. In this project, we have anticipated the reindeer herding Sami people and their interest to follow the prerequisites of land use and habitat changes over time. The project can partially be mentioned as a process consisting of a dialogue between reindeer herders, the Swedish Forest Agency, Vilhelmina Model Forest and the National Monitoring Programme NILS. The European project Baltic Landscape frames the project. The aim of Baltic Landscape is to demonstrate concrete examples of how conflicts related to land use claims can be solved. In this project, we worked specifically with the Model Forest concept that is based on a bottom-up perspective of working with issues related to landscapes and covering e.g. sector driven industry such as forestry, tourism, environmental values and governmental organizations. During the project all parts met and had theoretical sessions, field exercises and subsequent discussions that overall was about how best to monitor different habitats that are of large importance for the forage of reindeers (grazing types). More technical approaches such as Unmanned airplanes (so called UAV:s) were tested. Reindeer movements across the landscape range from the Alpine regions in the west to the coniferous forests on the east coast. The study includes the alpine landscape, mountain birch forest and marshlands in Vilhelmina Model Forest. The purpose: for reindeer herders was to find a method to conduct inventory on grazing types (reindeer habitats) that was rational to work with, i.e., not too time consuming (so that the inventory could be combined with the everyday work) and not too simple (so that it does not work as it is supposed to, as a support for discussion with other land users). for NILS was to initiate a dialogue with users and their needs of environmental monitoring data. More concretely, it was about to find out if there is data that can be of importance for reindeer herders which is not presently collected in the current field monitoring. Moreover to see if reindeer herders have the opportunity to collect data in a way so that it is possible to supplement existing NILS data. Finally to see if was possible to use unmanned aircraft, known as UAVs, to do inventory grazing types and especially hanging lichens (important as food supplement for reindeer). Moreover, interviews with stakeholders (N= 12) and reindeer herders (N= 1) , were made in order to deepen the knowledge of potential needs of NILS monitoring data for landuse and landscape planning by stakeholders in Vilhelmina Model Forest. for Vilhelmina Model Forest and the Swedish Forest Agency was to initiate dialogue between the parties and act as a coordinator and resource for increased dialogue. The results of the project (and process) revealed: that the importance of the possibility to conduct a dialogue. The dialogue led to the emergence of synergies that all parts could use. In this case the common denominator was to establish a specific area in the alpine region for field visits. The purpose was to use the area to promote and initiate dialogues about the landscape and in the longer perspective enable monitoring and increase knowledge about suitable usage of the landscape. NILS called such a surface Flagship areas, Vilhelmina Model forest call those areas Demo areas or geological parks (geopark). that it was possible to develop a rational functioning method of reindeer grazing types (linked to the Reindeer Husbandry Plans) based on field exercises and discussions conducted in this project 2012 -2014. During 2014 NILS personnel educate reindeer herders using the method developed within this project. that the methodology of inventory used by the NILS programme, both in field and by aerial photographs, is partly compatible with the existing reindeer grazing types. And also that NILS can benefit from dialogue with stakeholders and gain knowledge of which classification schemes can be converted into or what can be added to their inventory. that there is a wish to continue further dialogue between the partners. that interviews with stakeholder revealed the need of usefulness and costs for NILS data, that no no single variable was excluded as not interesting at all for any of the stakeholders (87 out of 356 NILS variables were asked for in the interview) and that stakeholders made suggestions of new variables that could complement the current NILS variable list.
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| 2. |
- Scholz, Birger, et al.
(författare)
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Impact of Temperature Dependent Sampling Procedures in Proteomics and Peptidomics : A Characterization of the Liver and Pancreas Post Mortem Degradome
- 2011
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 10:3, s. M900229MCP200-
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Tidskriftsartikel (refereegranskat)abstract
- Little is known about the nature of post mortem degradation of proteins and peptides on a global level, the so-called degradome. This is especially true for nonneural tissues. Degradome properties in relation to sampling procedures on different tissues are of great importance for the studies of, for instance, post translational modifications and/or the establishment of clinical biobanks. Here, snap freezing of fresh(< 2 min post mortem time) mouse liver and pancreas tissue is compared with rapid heat stabilization with regard to effects on the proteome (using two-dimensional differential in-gel electrophoresis) and peptidome (using label free liquid chromatography). We report several proteins and peptides that exhibit heightened degradation sensitivity, for instance superoxide dismutase in liver, and peptidyl-prolyl cis-trans isomerase and insulin C-peptides in pancreas. Tissue sampling based on snap freezing produces a greater amount of degradation products and lower levels of endogenous peptides than rapid heat stabilization. We also demonstrate that solely snap freezing related degradation can be attenuated by subsequent heat stabilization. We conclude that tissue sampling involving a rapid heat stabilization step is preferable to freezing with regard to proteomic and peptidomic sample quality.
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| 3. |
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| 4. |
- Wuttke, Matthias, et al.
(författare)
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A catalog of genetic loci associated with kidney function from analyses of a million individuals
- 2019
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Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
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Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
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| 5. |
- Ahmadi, Shilan Seyed, et al.
(författare)
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Risk factors for nephropathy in persons with type 1 diabetes: a population-based study
- 2022
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Ingår i: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 59, s. 761-772
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Tidskriftsartikel (refereegranskat)abstract
- Aims Albuminuria is strongly associated with risk of renal dysfunction, cardiovascular disease and mortality. However, clinical guidelines diverge, and evidence is sparse on what risk factor levels regarding blood pressure, blood lipids and BMI are needed to prevent albuminuria in adolescents and young adults with type 1 diabetes. Methods A total of 9347 children and adults with type 1 diabetes [mean age 15.3 years and mean diabetes duration 1.4 years at start of follow-up] from The Swedish National Diabetes Registry were followed from first registration until end of 2017. Levels for risk factors for a risk increase in nephropathy were evaluated, and the gradient of risk per 1 SD (standard deviation) was estimated to compare the impact of each risk factor. Results During the follow-up period, 8610 (92.1%) remained normoalbuminuric, 737 (7.9%) individuals developed micro- or macroalbuminuria at any time period of whom 132 (17.9% of 737) individuals developed macroalbuminuria. Blood pressure >= 140/80 mmHg was associated with increased risk of albuminuria (p <= 0.0001), as were triglycerides >= 1.0 mmol/L (p = 0.039), total cholesterol >= 5.0 mmol/L (p = 0.0003), HDL < 1.0 mmol/L (p = 0.013), LDL 3.5- < 4.0 mmol/L (p = 0.020), and BMI >= 30 kg/m(2) (p = 0.033). HbA1c was the strongest risk factor for any albuminuria estimated by the measure gradient of risk per 1 SD, followed by diastolic blood pressure, triglycerides, systolic blood pressure, cholesterol and LDL. In patients with HbA1c > 65 mmol/mol (> 8.1%), blood pressure > 140/70 mmHg was associated with increased risk of albuminuria. Conclusions Preventing renal complications in adolescents and young adults with type 1 diabetes need avoidance at relatively high levels of blood pressure, blood lipids and BMI, whereas very tight control is not associated with further risk reduction. For patients with long-term poor glycaemic control, stricter blood pressure control is advocated.
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| 6. |
- Ahmadi, Shilan Seyed, et al.
(författare)
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Risk of atrial fibrillation in persons with type 2 diabetes and the excess risk in relation to glycaemic control and renal function: a Swedish cohort study
- 2020
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Ingår i: Cardiovascular Diabetology. - : Springer Science and Business Media LLC. - 1475-2840. ; 19:1
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Tidskriftsartikel (refereegranskat)abstract
- Background To examine the incidence of atrial fibrillation in individuals with type 2 diabetes compared with age- and sex-matched controls from the general population and its variation in relation to glycaemic control and renal function. Methods A total of 421,855 patients with type 2 diabetes from the Swedish National Diabetes Registry and 2,131,223 controls from the Swedish Population Registry, matched for age, sex and county, were included and followed from January 1, 2001 to December 31, 2013. Results Overall, 8.9% of individuals with type 2 diabetes and 7.0% of controls were diagnosed with atrial fibrillation during follow-up, unadjusted incidence risk ratio (IRR) 1.35 (95% 1.33-1.36). Women < 55 years old with type 2 diabetes had an IRR of 2.36 (95% CI 2.10-2.66), in relation to controls, whereas the corresponding value for men < 55 years old with type 2 diabetes was IRR 1.78 (95% CI 1.67-1.90). In the fully adjusted Cox regression, the risk of type 2 diabetes on incident atrial fibrillation was 28% greater vs controls, hazard ratio (HR) 1.28 (95% CI 1.26-1.30), p < 0.0001. The excess risk of atrial fibrillation in individuals with type 2 diabetes increased with worsening glycaemic control and renal complications. For individuals with HbA1c <= 6.9% (<= 52 mmol/mol) and normoalbuminuria the excess risk vs controls was still increased, adjusted HR 1.16 (95% CI 1.14-1.19); p < 0.0001. Conclusions Individuals with type 2 diabetes had an overall 35% higher risk of atrial fibrillation compared to age- and sex-matched controls from the general population. The excess risk for atrial fibrillation increased with renal complications or with poor glycaemic control. Individuals with type 2 diabetes with good glycaemic control and normoalbuminuria had slightly increased risk.
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| 7. |
- Alvarez Díaz, María Guadalupe, et al.
(författare)
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The Mystery of Elin : Incorporating a City Cultural Program on History and Heritage into a Pervasive Game
- 2014
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Ingår i: IE2014 Proceedings of the 2014 Conference on Interactive Entertainment. - New York, NY, USA : ACM Digital Library. - 9781450327909 ; , s. 1-10
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Konferensbidrag (refereegranskat)abstract
- This paper reports on the use of mobile terminals in historical spaces to play an adventure game, using a location-based platform to awaken the fantasy and curiosity of children about cultural heritage; the design of a mystery game as the medium to convey content along with features shared by pervasive games, such as mobile exploration, team work, and the combination of virtual and real worlds. It includes the process of adapting history to storytelling and the results of using a method to evaluate the experience.
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| 10. |
- Axelsson, Robert, et al.
(författare)
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Evaluation of Multi-level Social Learning for Sustainable Landscapes : Perspective of a Development Initiative in Bergslagen, Sweden
- 2013
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Ingår i: Ambio. - : Springer Netherlands. - 0044-7447 .- 1654-7209. ; 42:2, s. 241-253
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Tidskriftsartikel (refereegranskat)abstract
- To implement policies about sustainable landscapes and rural development necessitates social learning about states and trends of sustainability indicators, norms that define sustainability, and adaptive multi-level governance. We evaluate the extent to which social learning at multiple governance levels for sustainable landscapes occur in 18 local development initiatives in the network of Sustainable Bergslagen in Sweden. We mapped activities over time, and interviewed key actors in the network about social learning. While activities resulted in exchange of experiences and some local solutions, a major challenge was to secure systematic social learning and make new knowledge explicit at multiple levels. None of the development initiatives used a systematic approach to secure social learning, and sustainability assessments were not made systematically. We discuss how social learning can be improved, and how a learning network of development initiatives could be realized.
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