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| 2. |
- Andersson, My, et al.
(författare)
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Optogenetic control of human neurons in organotypic brain cultures
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.
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| 3. |
- Assenova, Daniela, et al.
(författare)
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Bibliography for 2008
- 2010
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Ingår i: Slovo. - 0348-744X .- 2001-7359. ; 50, s. 157-160
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Assenova, Daniela, et al.
(författare)
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Bibliography for 2009
- 2010
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Ingår i: Slovo. - 0348-744X .- 2001-7359. ; 50, s. 161-165
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Benoni, Henrik, et al.
(författare)
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Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study
- 2020
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Ingår i: Transplant International. - : WILEY. - 0934-0874 .- 1432-2277. ; 33:12, s. 1700-1710
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Tidskriftsartikel (refereegranskat)abstract
- Kidney transplant recipients (KTRs) have an increased cancer risk compared to the general population, but absolute risks that better reflect the clinical impact of cancer are seldom estimated. All KTRs in Sweden, Norway, Denmark, and Finland, with a first transplantation between 1995 and 2011, were identified through national registries. Post-transplantation cancer occurrence was assessed through linkage with cancer registries. We estimated standardized incidence ratios (SIR), absolute excess risks (AER), and cumulative incidence of cancer in the presence of competing risks. Overall, 12 984 KTRs developed 2215 cancers. The incidence rate of cancer overall was threefold increased (SIR 3.3, 95% confidence interval [CI]: 3.2-3.4). The AER of any cancer was 1560 cases (95% CI: 1468-1656) per 100 000 person-years. The highest AERs were observed for nonmelanoma skin cancer (838, 95% CI: 778-901), non-Hodgkin lymphoma (145, 95% CI: 119-174), lung cancer (126, 95% CI: 98.2-149), and kidney cancer (122, 95% CI: 98.0-149). The five- and ten-year cumulative incidence of any cancer was 8.1% (95% CI: 7.6-8.6%) and 16.8% (95% CI: 16.0-17.6%), respectively. Excess cancer risks were observed among Nordic KTRs for a wide range of cancers. Overall, 1 in 6 patients developed cancer within ten years, supporting extensive post-transplantation cancer vigilance.
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| 7. |
- Bredewold, Obbo W, et al.
(författare)
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Cardiovascular Risk Following Conversion to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients : A Randomized Clinical Trial
- 2023
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Ingår i: Kidney Medicine. - : Elsevier. - 2590-0595. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- RATIONALE & OBJECTIVE: In kidney transplant recipients (KTRs), a belatacept-based immunosuppressive regimen is associated with beneficial effects on cardiovascular (CV) risk factors compared with calcineurin inhibitor (CNI)-based regimens. Our objective was to compare the calculated CV risk between belatacept and CNI (predominantly tacrolimus) treatments using a validated model developed for KTRs.STUDY DESIGN: Prospective, randomized, open-label, parallel-group, investigator-initiated, international multicenter trial.SETTING & PARTICIPANTS: KTRs aged 18-80 years with a stable graft function (estimated glomerular filtration rate > 20 mL/min/1.73 m2), 3-60 months after transplantation, treated with tacrolimus or cyclosporine A, were eligible for inclusion.INTERVENTION: Continuation with a CNI-based regimen or switch to belatacept for 12 months.OUTCOMES: Comparison of the change in the estimated 7-year risk of major adverse CV events and all-cause mortality, changes in traditional markers of CV health, as well as measures of arterial stiffness.RESULTS: Among the 105 KTRs randomized, we found no differences between the treatment groups in the predicted risk for major adverse CV events or mortality. Diastolic blood pressure, measured both centrally by using a SphygmoCor device and peripherally, was lower after the belatacept treatment than after the CNI treatment. The mean changes in traditional cardiovascular (CV) risk factors, including kidney transplant function, were otherwise similar in both the treatment groups. The belatacept group had 4 acute rejection episodes; 2 were severe rejections, of which 1 led to graft loss.LIMITATIONS: The heterogeneous baseline estimated glomerular filtration rate and time from transplantation to trial enrollment in the participants. A limited study duration of 1 year.CONCLUSIONS: We found no effects on the calculated CV risk by switching to the belatacept treatment. Participants in the belatacept group had not only lower central and peripheral diastolic blood pressure but also a higher rejection rate.FUNDING: The trial has received a financial grant from Bristol-Myers Squibb.TRIAL REGISTRATION: EudraCT no. 2013-001178-20.
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| 9. |
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| 10. |
- Egnell, Susanne
(författare)
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Drug policing of youth : examining pre- and post-stop conditions and outcomes
- 2023
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Given the strong focus on minor drug offenses in Swedish drug control policy and the risk of disparate drug enforcement that may follow from such policies, this thesis explores drug enforcement and the use of coercive measures (enforced drug tests and body searches) towards youths aged 15-20 years. The first study focuses on the circumstances of the detection of minor drug offenses, the grounds for suspicion and use of coercive measures. The second study explores ethnic disparities in exposure to drug tests, as well as ethnic disparities in relation to hitrates for drug tests and body searches. The results show that about one-third of the minor drug situations were detected in a reactive policing manner, and approximately 30-40 percent were detected in association with other offenses. The findings suggest that the grounds for enforcing drug tests and body searches often were based on subjective cues. Results from the second study show that youths subjected to a drug test were male, born outside Europe, and had unemployed fathers to a significantly greater extent than the drug-using youths in the school survey. Additionally, youths born outside Europe were more likely than youths born in Sweden to be submitted to coercive measures that produced a negative result. This finding was dependent on the definition of ethnic background that was employed. The findings suggest that future research should investigate a number of pre- and post-stop conditions and outcomes. Research on pre-stop conditions should further explore: 1) the distribution of "criminal" signs between different sociodemographic groups and their probability for a hit, 2) the importance of concurrent offending for the detection of drug offenses, and 3) the nature of drug use, transactions, and dealing in association with the risk for suspicion. Research on post-stop conditions and outcomes should explore: 1) ethnic disparities in hitrates of body searches and drug tests with more detailed data on ethnic background (specific region-based vulnerabilities), and 2) neighborhood effects on searches and drug tests, including hit-rates, both on an individual level and a neighborhood level. Research on various forms of police bias in drug enforcement should integrate both neighborhood- and individual-level processes in relation to pre-stop and post-stop conditions and outcomes to understand the mechanisms behind ethnic disparities. Finally, future research should focus on the "gender gap" found in this study and previous studies on drug enforcement.
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