| 1. |
- Ahlbeck Bergendahl, Ida, et al.
(författare)
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Fisk- och skaldjursbestånd i hav och sötvatten 2016 : Resursöversikt
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I rapporten kan du ta del av bedömningen som görs av situationen för bestånd som regleras inom ramen för EU:s gemensamma fiskeripolitik (GFP). Bedömningarna baseras på det forskningssamarbete och den rådgivning som sker inom det Internationella Havsforskningsrådet (ICES).De bestånd som förvaltas nationellt baseras på de biologiska underlagen, och rådgivningen i huvudsak på den forskning och övervakning samt analys som bedrivs av Institutionen för akvatiska resurser vid Sveriges lantbruksuniversitet (SLU Aqua) samt yrkesfiskets rapportering.Rapporten omfattar 41 fiskarter uppdelade i olika bestånd, samt sju skal- och blötdjursarter.Nytt för årets upplaga är kapitlet om ekosystemtjänster. Avsnittet beskriver de fördelar människan får genom ekosystemen, till exempel hur fisk och skaldjur kommer till nytta för människan genom föda, rekreation och biologisk mångfald. Nytt för i år är också att rapportens diagram och figurer anpassats för läsare med defekt färgseende.Översikten är utarbetad av SLU Aqua på uppdrag av Havs- och vattenmyndigheten.
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| 2. |
- Hammarström, Lars G. J., et al.
(författare)
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The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features
- 2016
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 59:18, s. 8577-8592
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Tidskriftsartikel (refereegranskat)abstract
- Glioblastoma remains an incurable brain cancer. Drugs developed in the past 20 years have not improved the prognosis for patients, necessitating the development of new treatments. We have previously reported the therapeutic potential of the quinoline methanol Vacquinol-1 (1) that targets glioblastoma cells and induces cell death by catastrophic vacuolization. Compound 1 is a mixture of four stereoisomers due to the two adjacent stereogenic centers in the molecule, complicating further development in the preclinical setting. This work describes the isolation and characterization of the individual isomers of 1 and shows that these display stereospecific pharmacokinetic and pharmacodynamic features. In addition, we present a stereoselective synthesis of the active isomers, providing a basis for further development of this compound series into a novel experimental therapeutic for glioblastoma.
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| 3. |
- Johansson, Ingela, et al.
(författare)
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Vilken litteratur (o)synliggörs inom romanska språk i svensk högre utbildning och forskning?
- 2020
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Ingår i: Litteraturdidaktik : Språkämnen i samverkan - Språkämnen i samverkan. - 9789127826885 ; , s. 200-228
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Bokkapitel (refereegranskat)abstract
- Studien kartlägger litteraturämnen i kandidatuppsatser och avhandlingar i romanska språk i Sverige under tidsperioden 2000-2016. Syftet är att belysa olika litteraturers roll och (o)synliggörande i självständiga arbeten. Ansatsen är deskriptiv och ämnar identifiera mönster och tendenser i materialet. Dessa mönster ska ligga till grund för fördjupade studier av områden med utvecklingspotential i de enskilda romanska språken, i grundutbildning såväl som på avancerad nivå. Materialet är valt för att fånga övergången från grundnivå till forskarnivå i utbildningen. Hypotesen som studien avser att undersöka formuleras av att uppsatser och avhandlingar speglar både undervisningens innehåll och studenters egna intressen. Hur orienterar sig studenters självständiga arbeten med avseende på reproduktion av givna traditioner och/eller innovativa ämnesval? Genom de för språken gemensamma analyskriterierna kön, epok, genre och ursprung visar de övergripande resultaten att manliga författare - företrädesvis vita och döda - starkt dominerar ämnesvalen, att 1900-talet har en stark ställning som epok, att prosagenren, underförstått romanen, är det vanligaste valet samt att franskan och italienskan för fram författarskap från Frankrike och Italien, medan spanskan och portugisiskan uppvisar större internationell bredd, med författarskap från både Latinamerika och den afrikanska kontinenten. Studien ger en inblick i möjliga datainsamlingsmetoder samt ger exempel på hur man i forskning kan presentera kvantitativa data i syfte att belysa mönster, för att därigenom få syn på förbättringsområden inom högre utbildning i romanska språk.
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| 4. |
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| 5. |
- Svensson, Madeleine, 1983-, et al.
(författare)
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Strategies to Encourage E-health : The Effects of Using Different Reminders to Various Extents on Overall Response Patterns in a Large Randomized Internet-based Intervention Study
- 2011
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Konferensbidrag (refereegranskat)abstract
- BackgroundThe use of the Internet as a research tool has dramatically increased in the past several years. Yet, the current literature favors the response rate achieved from paper-based studies. Knowledge of successful methods to increase participation in Internet-based research is scarce. The objective of this study is to examine the effects of different reminders to encourage study participation on overall response patterns in an Internet-based intervention study.MethodsIn 2008, 3,876 employees at four companies in the railway sector in Sweden were randomly e-mailed an Internet-based lifestyle questionnaire consisting of: A) questions, B) questions + interactive personalized automated feedback, or C) questions + interactive personalized automated feedback + telephone counseling. The questionnaire assessed health aspects including diet, physical activity, sleep, stress, alcohol/tobacco consumption, and motivation to change health. Interactive feedback was provided for all health sections; telephone counseling was offered for diet, physical activity, alcohol and smoking habits. Nine months later, a follow-up questionnaire (C) was e-mailed to examine health improvements. 4-5 and 11 e-mail reminders were sent at baseline and follow-up, respectively. Additional reminders (flyers, texts in internal media/bulletin board, information talks, SMS, visit by the research group etc) were also administered at the four companies, to various extents. The number of additional reminders was summarized and analyses were based on the total number of received additional reminders (low, moderate or high). Response patterns were examined in relation to basic characteristics, company, work type (office/field worker), received e-mail reminders, and total number of received additional reminders. As a result of the study, the companies received recommendations for future health implementations.Results38% and 36% completed the baseline and follow-up questionnaire, respectively. The majority of the participants was male, non-smokers, employed as field workers, and had a BMI ≥25. The 4-5 e-mail reminders increased the total response rate by 15%; the 11 e-mail reminders by 21%. Additional reminders had a marginal effect on total response rate, yet generated a positive effective on the response rate among office workers (71%). Since the planning process of the study, the company involved had the highest overall response rate (61%: P<0.001), despite receiving a moderate number of additional reminders. The employees at this company were almost 1.80 (CI: 1.55-2.08) times more likely to participate in the baseline questionnaire, compared to the company which entered the study just prior to the start and had the lowest overall response rate. Participant characteristics including sex, age, BMI, smoking, motivation to change health habits, and version of the completed questionnaire (A, B or C) were not associated with time of response. The highest participation at follow-up, however, was found for those who completed baseline questionnaire A, consisting solely of questions.ConclusionsA well-established collaboration with the participants prior to study start and to send out e-mail reminders on a continuous basis are two effective strategies to increase the response rate in Internet-based studies. Additional reminders conducted in the work setting may only be effective among office workers participating in Internet-based studies.
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| 6. |
- Svensson, Madeleine, 1983-, et al.
(författare)
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The effect of reminders in a web-based intervention study
- 2012
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Ingår i: European Journal of Epidemiology. - Dordrecht : Springer Netherlands. - 0393-2990 .- 1573-7284. ; 27:5, s. 333-340
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Tidskriftsartikel (refereegranskat)abstract
- Knowledge on effective strategies to encourage participation in epidemiological web-based research is scant. We studied the effects of reminders on overall participation. 3,876 employees were e-mailed a baseline web-based lifestyle questionnaire. Nine months later, a follow-up questionnaire was sent. To encourage study participation, 4–5 and 11 e-mail reminders were sent at baseline and follow-up, respectively. Additional reminders (media articles, flyers, SMS etc) were also administered. Reminders (e-mails + additional) were given in low (≤6 reminders), medium (7–9 reminders) or high amounts (>9 reminders). Participation was examined with respect to participant characteristics (i.e. age, sex, Body Mass Index, occupation), type/number of reminders, and time of participation. Most participants were males, 35–49 years, and field workers (non-office based). About 29 % responded before any e-mail reminder, following 26 and 45 % after 1 respective ≥ 2 e-mail reminders. Participant characteristics were not related to when the participants responded. The 4–5 e-mail reminders increased total response rate by 15 %, the eleven by 21 % (greatest increases in September). Those receiving medium amounts of reminders (reference) had the highest response rate (75 %), likewise office workers (54 %) compared to field workers (33 %). High amounts of reminders were particularly effective on office workers. The participants’ characteristics were not related to when they responded in this web-based study. Frequent reminders were effective on response rates, especially for those with high Internet availability. The highest increases in response rates were found in September. © The Author(s) 2012.
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| 7. |
- Svensson, Tobias, et al.
(författare)
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Conjugated Pneumococcal Vaccine Triggers a Better Immune Response than Polysaccharide Pneumococcal Vaccine in Patients with Chronic Lymphocytic Leukemia : A Randomized Study by the Swedish CLL group
- 2018
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Ingår i: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 36:25, s. 3701-3707
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To determine if patients with untreated chronic lymphocytic leukemia (CLL) benefit from vaccination with a 13-valent conjugated pneumococcal vaccine (PCV13), Prevenar13®, compared with a 23-valent capsular polysaccharide vaccine (PPSV23), Pneumovax®, in terms of immune response. Background: Patients with CLL have an increased risk for infection and Streptococcus pneumoniae is one of the most common pathogens with high morbidity. Patients with CLL are known to respond poorly to the traditionally used polysaccharide vaccines. Conjugation of polysaccharide to protein carriers renders a thymus-dependent, memory-inducing and more immunogenic vaccine. In patients with CLL, there is no consensus on a recommendation for pneumococcal vaccination, due to a lack of comparative studies. Methods: 128 treatment naïve CLL patients from eight hematology clinics in Sweden were randomized to vaccination with PCV13 (n=63) or PPSV23 (n=65) after stratification by IgG levels and CLL clinical stage (Rai). Blood samples for evaluation of immune response were obtained at baseline, at one and at six months after vaccination. Analyses for each of the 12 pneumococcal serotypes common for PCV13 and PPSV23 were performed by opsonophagocytic assay (OPA) and enzyme-linked immunosorbent assay (ELISA). Results: PCV13 elicited a superior immune response than PPSV23 in 10/12 serotypes one month after vaccination and in 5/12 serotypes six months after vaccination, measured as OPA geometric mean titers (GMTs). Geometric mean concentrations of serotype-specific IgG antibodies elicited by PCV13 as measured by ELISA, were higher than those elicited by PPSV23 in half of the common serotypes, both after one and six months. The proportion of patients with good response (defined as response in 8 of 12 common serotypes according to predefined response criteria) was higher in PCV13 recipients than in PPSV23 recipients after one month (40% vs. 22%, p=0.034) as well as after six months (33% vs. 17%, p=0.041). Never did PPSV23 trigger a better immune response for any of the serotypes, than PCV13, regardless of analysis. For two of the serotypes, OPA GMTs were lower at the six months than at the one-month follow up. Negative predictive factors for vaccination response were hypogammaglobulinemia and long disease duration. Both vaccines were well tolerated. Conclusions: In patients with previously untreated CLL, the efficacy of PCV13 in terms of immune response is superior to PPSV23 for many serotypes common for the two vaccines. PCV13 should be considered as a part in vaccination programs against Streptococcus pneumoniae for these patients and administered as early as possible during the course of the disease.
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| 8. |
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| 9. |
- Ahlbeck Bergendahl, Ida, et al.
(författare)
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Fisk- och skaldjursbestånd i hav och sötvatten 2017 : Resursöversikt
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I rapporten kan du ta del av bedömningen som görs av situationen för bestånd som regleras inom ramen för EU:s gemensamma fiskeripolitik (GFP). Bedömningarna baseras på det forskningssamarbete och den rådgivning som sker inom det Internationella Havsforskningsrådet (ICES).De bestånd som förvaltas nationellt baseras på de biologiska underlagen, och rådgivningen i huvudsak på den forskning och övervakning samt analys som bedrivs av Institutionen för akvatiska resurser vid Sveriges lantbruksuniversitet (SLU Aqua) samt yrkesfiskets rapportering.Rapporten omfattar 41 fiskarter och sju skaldjursarter.Nytt för i år är att vi även beskriver fritidsfisket mer utförligt. Det fisket får allt större betydelse för utvecklingen av många av Sveriges bestånd av fisk- och skaldjur, till exempel sötvattens- och kustlevande arter som abborre, gädda, gös, lax, röding och öring, liksom marina arter som torsk och hummerÖversikten är utarbetad av SLU Aqua på uppdrag av Havs- och vattenmyndigheten.
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| 10. |
- Alkmark, Mårten, 1973, et al.
(författare)
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Induction of labour at 41weeks of gestation versus expectant management and induction of labour at 42weeks of gestation: a cost-effectiveness analysis
- 2022
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Ingår i: BJOG: An International Journal of Obstetrics and Gynaecology. - : Wiley. - 1470-0328 .- 1471-0528. ; 129:13, s. 2157-2165
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To assess the cost-effectiveness of induction of labour (IOL) at 41weeks of gestation compared with expectant management until 42weeks of gestation. Design: A cost-effectiveness analysis alongside the Swedish Post-term Induction Study (SWEPIS), a multicentre, randomised controlled superiority trial. Setting: Fourteen Swedish hospitals during 2016–2018. Population: Women with an uncomplicated singleton pregnancy with a fetus in cephalic position were randomised at 41weeks of gestation to IOL or to expectant management and induction at 42weeks of gestation. Methods: Health benefits were measured in life years and quality-adjusted life years (QALYs) for mother and child. Total cost per birth was calculated, including healthcare costs from randomisation to discharge after delivery, for mother and child. Incremental cost-effectiveness ratios (ICERs) were calculated by dividing the difference in mean cost between the trial arms by the difference in life years and QALYs, respectively. Sampling uncertainty was evaluated using non-parametric bootstrapping. Main outcome measures: The cost per gained life year and per gained QALY. Results: The differences in life years and QALYs gained were driven by the difference in perinatal mortality alone. The absolute risk reduction in mortality was 0.004 (from 6/1373 to 0/1373). Based on Swedish life tables, this gives a mean gain in discounted life years and QALYs of 0.14 and 0.12 per birth, respectively. The mean cost per birth was €4108 in the IOL group (n=1373) and €4037 in the expectant management group (n=1373), with a mean difference of €71 (95%CI −€232 to €379). The ICER for IOL compared with expectant management was €545 per life year gained and €623 per QALY gained. Confidence intervals were relatively wide and included the possibility that IOL had both lower costs and better health outcomes. Conclusions: Induction of labour at 41weeks of gestation results in a better health outcome and no significant difference in costs. IOL is cost-effective compared with expectant management until 42weeks of gestation using standard threshold values for acceptable cost per life year/QALY. Tweetable abstract: Induction of labour at 41weeks of gestation is cost-effective compared with expectant management until 42weeks of gestation.
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