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- Abuhasanein, Suleiman, et al.
(författare)
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Diagnostic value of repeated comprehensive investigation with CT urography and cystoscopy for recurrent macroscopic haematuria
- 2024
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Ingår i: BJUI Compass. - : John Wiley & Sons. - 2688-4526. ; 5:2, s. 253-260
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To perform a descriptive analysis of a series of patients with recurrent macroscopic haematuria after a primary standard evaluation including computed tomography urography (CTU) and cystoscopy negative for urinary bladder cancer (UBC) and upper tract urothelial cancer (UTUC) and to identify potential factors associated with occurrence of recurrent macroscopic haematuria.Methods: All patients older than 50 years who underwent urological investigation for macroscopic haematuria with both cystoscopy and CTU 2015-2017 were retrospectively reviewed. A descriptive analysis of the primary and later investigations for recurrent macroscopic haematuria was performed. To investigate the association between explanatory variables and the occurrence of recurrent macroscopic haematuria, a Poisson regression analysis was performed.Results: A total of 1395 eligible individuals with primary standard investigation negative for UBC and UTUC were included. During a median follow-up of 6.2 (IQR 5.3-7) years, 248 (18%) patients had recurrent macroscopic haematuria, of whom six patients were diagnosed with UBC, two with prostate cancer, one with renal cell carcinoma and one had a suspected UTUC at the repeated investigation. Within 3 years, 148 patients (11%) experienced recurrent macroscopic haematuria, of whom two patients were diagnosed with low-grade UBC (TaG1-2), one with T2G3 UBC and one with low-risk prostate cancer. The presence of an indwelling catheter, use of antithrombotic medication, pathological findings at CTU or cystoscopy or history of pelvic radiotherapy were all statistically significant independent predictors for increased risk for recurrent macroscopic haematuria.Conclusion: In the case of recurrent macroscopic haematuria within 3 years of primary standard evaluation for urinary tract cancer, there was a low risk of later urological malignancies in patients initially negative for UBC and UTUC. Therefore, waiting 3 years before conducting another complete investigation in cases of recurrent macroscopic haematuria might be appropriate.
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- Greenwood, Sarah L., et al.
(författare)
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Multiple re-advances of a Lake Vättern outlet glacier during Fennoscandian Ice Sheet retreat, south-central Sweden
- 2015
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Ingår i: Boreas. - : Wiley. - 0300-9483 .- 1502-3885. ; 44:4, s. 619-637
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Tidskriftsartikel (refereegranskat)abstract
- Lake Vättern represents a critical region geographically and dynamically in the deglaciation of the Fennoscandian Ice Sheet. The outlet glacier that occupied the basin and its behaviour during ice-sheet retreat were key to the development and drainage of the Baltic Ice Lake, dammed just west of the basin, yet its geometry, extent, thickness, margin dynamics, timing and sensitivity to regional retreat forcing are rather poorly known. The submerged sediment archives of Lake Vättern represent a missing component of the regional Swedish deglaciation history. Newly collected geophysical data, including high-resolution multibeam bathymetry of the lake floor and seismic reflection profiles of southern Lake Vättern, are used here together with a unique 74-m sediment record recently acquired by drill coring, and with onshore LiDAR-based geomorphological analysis, to investigate the deglacial environments and dynamics in the basin and its terrestrial environs. Five stratigraphical units comprise a thick subglacial package attributed to the last glacial period (and probably earlier), and an overlying > 120-m deglacial sequence. Three distinct retreat-re-advance episodes occurred in southern Lake Vättern between the initial deglaciation and the Younger Dryas. In the most recent of these, ice overrode proglacial lake sediments and re-advanced from north of Visingsö to the southern reaches of the lake, where ice up to 400 m thick encroached on land in a lobate fashion, moulding crag-and-tail lineations and depositing till above earlier glacifluvial sediments. This event precedes the Younger Dryas, which our data reveal was probably restricted to north-central sectors of the basin. These dynamics, and their position within the regional retreat chronology, indicate a highly active ice margin during deglaciation, with retreat rates on average 175 m a(-1). The pronounced topography of the Vättern basin and its deep proglacial-dammed lake are likely to have encouraged the dynamic behaviour of this major Fennoscandian outlet glacier.
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| 5. |
- Jakobsson, Martin, et al.
(författare)
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Major earthquake at the Pleistocene-Holocene transition in Lake Vattern, southern Sweden
- 2014
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Ingår i: Geology. - 0091-7613 .- 1943-2682. ; 42:5, s. 379-382
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Tidskriftsartikel (refereegranskat)abstract
- Lake Vattern, Sweden, is within a graben that formed through rifting along the boundary between two Precambrian terrains. Geophysical mapping and geological coring show that substantial tectonic movements along the Lake Vattern graben occurred at the very onset of the Holocene. This is evident from deformation structures in the soft sediment accumulated on the lake floor. Our interpretation of these structures suggests as much as 13 m of vertical tectonic displacements along sections of a >80-km-long fault system. If these large displacements are from one tectonic event, Lake Vattern must have had an earthquake with seismic moment magnitudes to 7.5. In addition, our geophysical mapping shows large landslides along sections of the steep lake shores. Pollen analysis of sediment infillings of some of the most prominent sediment deformation structures places this major seismic event at the Younger Dryas-Preboreal transition, ca. 11.5 ka. We suggest that this event is mainly related to the rapid release of ice-sheet load following the deglaciation. This paleoseismic event in Lake Vattern ranks among the larger known intraplate tectonic events in Scandinavia and attests to the significance of glacio-isostatic unloading.
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- O`Regan, Matt, et al.
(författare)
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Early Holocene sea level in the Canadian Beaufort Sea constrained by radiocarbon dates from a deep borehole in the Mackenzie Trough, Arctic Canada
- 2018
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Ingår i: Boreas. - : Wiley. - 0300-9483 .- 1502-3885. ; 47:4, s. 1102-1117
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Tidskriftsartikel (refereegranskat)abstract
- Deglacial and Holocene relative sea level (RSL) in the Canadian Beaufort Sea was influenced by the timing and extent of glacial ice in the Mackenzie River corridor and adjacent coastal plains. Considerable evidence indicates extensive ice cover in this region of northwestern Canada during the Late Wisconsinan. However, no absolute ages exist to constrain maximum RSL lowering before the late Holocene (4.2-0ka). In 1984, the Geological Survey of Canada drilled an 81.5-m-deep borehole in the western Mackenzie Trough at 45m water depth (MTW01). The lower 52.5m of the borehole was interpreted as a deltaic progradational sequence deposited during a period of rising sea level. The upper 29m was described as foraminifer-bearing marine sediments deposited after transgression of the site, when RSL rose above similar to-74m. Here, we present radiocarbon measurements from MTW01, acquired from benthic foraminifera, mollusc fragments and particulate organic carbon in the >63m fraction (POC>63m) in an attempt to constrain the chronology of sediments within this borehole and date the timing of transgression. The deepest carbonate macrofossil was acquired from 8m above the transgressive surface (equivalent to 21m b.s.l.), where mollusc fragments returned a date of 9400 +180-260cal. a BP (2 sigma). This provides the oldest constraint on Holocene sea-level lowering in the region, and implies that transgression at this site occurred prior to the early Holocene. Ages obtained from the lower 52.5m of the borehole are limited to POC>63m samples. These indicate that progradational sediments were deposited rapidly after 24820 +390-380cal. a BP (2 sigma). Due to the incorporation of older reworked organic matter, the actual age of progradation is likely to be younger, occurring after Late Wisconsinan glacial ice retreated from the coast.
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| 7. |
- O'Regan, Matt, et al.
(författare)
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Geotechnical and sedimentary evidence for thick-grounded ice in southern Lake Vättern during deglaciation
- 2016
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Ingår i: GFF. - : Informa UK Limited. - 1103-5897 .- 2000-0863. ; 138:2, s. 355-366
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Tidskriftsartikel (refereegranskat)abstract
- A 74-meter Late Pleistocene to Holocene sedimentary sequence was recovered from southern Lake Vattern in the autumn of 2012. At approximate to 54m below the lake floor, shear strength and high-resolution bulk density measurements suggest the presence of an unconformity in the varved proglacial clays. Incremental load consolidation tests reveal highly overconsolidated sediments below this level. Preconsolidation pressures for the underlying sediments are between 1250 and 2100kPa, up to approximate to 1700kPa more than the current in-situ effective stress. The highly overconsolidated sediments indicate either substantial erosion (the removal of 215-360m of sediment), or consolidation under a large grounded ice mass sitting up to 230m above paleo-lake level. Glaciotectonic deformation in underlying sediments supports the interpretation of a grounded ice mass. It is likely that this horizon is either contemporaneous with or older than the Levene moraine, formed between 13.4 and 13.8ka. In the approximate to 30m of overlying proglacial clays, there is no further evidence for grounded ice, indicating that any ice advance to southern Lake Vattern during the Younger Dryas would have been limited to an extremely thin ice tongue.
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| 8. |
- Preto, Pedro, et al.
(författare)
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Geothermal evidence for groundwater flow through Quaternary sediments overlying bedrock aquifers below Lake V?ttern, Sweden
- 2019
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Ingår i: GFF. - : Informa UK Limited. - 1103-5897 .- 2000-0863. ; 141:2, s. 106-120
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Tidskriftsartikel (refereegranskat)abstract
- Groundwater discharge into lakes is an important component of the fluid and nutrient budgets, and a possible route for contaminant transport. However, groundwater flow beneath lakes is difficult to investigate due to the need for drilling deep boreholes. In 2012, a 2,000 m deep borehole was drilled in Lake Vättern, the second largest lake in Sweden. A continuous temperature profile was collected from the borehole. The geothermal gradient in the upper 180 m is highly non-linear, and not controlled by variability in the measured thermal properties of the sediments and rocks. The anomalous temperature profile is best explained by fluid flow into the borehole and subsequent vertical flow of warm waters towards the lake floor. Combining the temperature profile with stratigraphic information from drilling logs and seismic data, we find that fluid flow into the borehole occurs in glacial and glaciofluvial sediments deposited on top of a large sandstone aquifer (the Visingsö Group). The warm waters flowing through the glacial and glaciofluvial sediments are likely sourced from the underlying Visingsö Group sandstones. There is no evidence for substantial vertical migration of these waters through the overlying glacial and postglacial sediments. We speculate that they escape either along lake margins where overlying sediments become thinner, or along faults that are known to exist in the deeper basin.These results highlight an important hydraulic transport pathway between recognised regional aquifers and Lake Vättern. Further work is needed to evaluate the significance of groundwater discharge on the water and nutrient budget of the lake.
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| 9. |
- Scherstén, Henrik, 1956, et al.
(författare)
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ECMO kan vara brygga till lungtransplantation : Ny metod räddar liv vid akut lungsvikt, visar retrospektiv studie.
- 2011
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Ingår i: Läkartidningen. - 0023-7205. ; 108:32-33, s. 1493-7
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Tidskriftsartikel (refereegranskat)abstract
- Lungtransplantation har utförts i Sverige sedan 20 år. Patienter som snabbt försämras i akut lungsvikt och inte återhämtar sig med konservativ behandling har tidigare bedömts som inte transplantabla och därför avlidit. Sedan några år använder vi i utvalda fall extrakorporeal membranoxygenering (ECMO) som brygga till lungtransplantation hos annars döende patienter. Överlevnaden för patienter som behandlats med ECMO syftande till lungtransplantation var 73 procent (8/11). Överlevnaden för dem som sedan genomgick lungtransplantation var 89 procent (8/9). Ingreppen genererade en hel del morbiditet, dock mest av övergående natur. Vi anser att ECMO-behandling i selekterade fall kan erbjudas yngre och medelålders patienter, trots att behandlingen i sig väcker frågor om morbiditet, kostnader och resursförbrukning. Det återstår att utvärdera långtidsresultaten hos patienter som genomgått ECMO-behandling som brygga till lungtransplantation.
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| 10. |
- Swärd, Henrik, et al.
(författare)
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A chronology of environmental changes in the Lake Vättern basin from deglaciation to its final isolation
- 2018
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Ingår i: Boreas. - : Wiley. - 0300-9483 .- 1502-3885. ; 47:2, s. 609-624
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Tidskriftsartikel (refereegranskat)abstract
- During and after deglaciation, Lake Vättern developed from a proglacial lake situated at the westernmost rim of the Baltic Ice Lake (BIL), into a brackish water body connecting the North Sea and the Baltic Sea, and finally into an isolated freshwater lake. Here we present geochemical and mineralogical data from a 70‐m composite sediment core recovered in southern Lake Vättern. Together with a radiocarbon age model of this core, we are able to delineate the character and timing of the different lake stages. In addition to a common mineralogical background signature seen throughout the sediment core, the proglacial sediments bear a calcite imprint representing ice‐sheet transported material from the limestone bedrock that borders the lake basin in the northeast. The proglacial fresh to brackish water transition is dated to 11 480±290 cal. a BP and is in close agreement with other regional chronologies. The brackish period lasted c. 300 years and was followed by a c. 1600 year freshwater period before the Vättern basin became isolated from the Initial Littorina Sea. Decreasing detrital input, increasing δ13C values and the appearance of diatoms in the upper 15 m of the sediment succession are interpreted as an overall increase in biological productivity. This mode of sedimentation continues until the present and is interpreted to mark the final isolation of the lake at 9530±50 cal. a BP. Consequently, the isolation of Lake Vättern was not an outcome of the Ancylus Lake regression, but rather because of ongoing continental uplift in the early Littorina period.
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