| 1. |
- Hansson, T., et al.
(författare)
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High temperature fracture of a SiC whisker-reinforced alumina in air and vacuum
- 1994
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Ingår i: Journal of the European Ceramic Society. - : Elsevier BV. - 0955-2219 .- 1873-619X. ; 13:5, s. 427-436
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Tidskriftsartikel (refereegranskat)abstract
- The fracture behaviour of a SiCw/alumina composite was studied between room temperature and 1320°C in vacuum by four-point bend testing of specimens pre-cracked by bridge indentation. The results are compared to those of earlier work on a similar material in air. In vacuum, the composite begins to exhibit stable crack growth (SCG) and increasing apparent toughness at about 1100°C. Between 1100 and 1320°C, the extent of SCG increases and the toughness rises to almost three times the room temperature fracture toughness. The toughness enhancement is due mainly to such processes as crack deflection, crack branching, microcrack zone formation and crack tip blunting rather than any temperature-related increase in intrinsic fracture resistance of the material. In air, the fracture processes are similar to those in vacuum but the toughness increase is delayed by about 100°C and the level of toughening is lower. These differences arise from the formation of a glass phase in air which delays microcrack formation but reduces the resistance to stable crack growth.
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| 2. |
- Hay-Schmidt, Anders, et al.
(författare)
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Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour
- 2017
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Ingår i: Reproduction. - : Bioscientifica. - 1470-1626 .- 1476-3990. ; 154:2, s. 145-152
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Tidskriftsartikel (refereegranskat)abstract
- Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinised during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood. Both androgens and prostaglandins are known to be inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we found that exposure to APAP decreased neuronal number in the sexually dimorphic nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male adult offspring. Likewise, exposure to the environmental pollutant and precursor of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in the SDNPOA is associated with reductions in male sexual behaviour. Consistent with the changes, male mice exposed in uteri to APAP exhibited changes in urinary marking behaviour as adults and had a less aggressive territorial display towards intruders of the same gender. Additionally, exposed males had reduced intromissions and ejaculations during mating with females in oestrus. Together, these data suggest that prenatal exposure to APAP may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming. These findings add to the growing body of evidence suggesting the need to limit the widespread exposure and use of APAP by pregnant women.
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