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Sökning: WFRF:(Szentesi A)

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  • Pioro, Michal, et al. (författare)
  • On open shortest path first related network optimisation problems
  • 2002
  • Ingår i: Performance Evaluation. - 0166-5316. ; 48:1-4, s. 201-223
  • Tidskriftsartikel (refereegranskat)abstract
    • The paper deals with flow allocation problems in IP networks using open shortest path first (OSPF) routing. Its main purpose is to discuss and propose methods for finding settlements of OSPF link weight system realising the assumed demand pattern for the given network resources (links capacities). Such settlements can result in a significantly better network performance, as compared with the simplified weight setting heuristics typically used nowadays. Although the configuration of the link weight system is primarily done in the network planning phase, still additional re-optimisations are feasible, and in fact essential, in order to cope with major changes in traffic conditions and with major resources' failures and rearrangements. The paper formulates a relevant OSPF routing optimisation problem, proves its NP-completeness, and discusses possible heuristic approaches and related optimisation methods for solving it. Two basic approaches are considered (the direct approach and the two-phase approach) and the resulting optimisation algorithms are presented. The considerations are illustrated with numerical results. (C) 2002 Elsevier Science B.V. All rights reserved.
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  • Pierantozzi, E., et al. (författare)
  • Impaired Intracellular Ca2+ Dynamics, M-Band and Sarcomere Fragility in Skeletal Muscles of Obscurin KO Mice
  • 2022
  • Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Obscurin is a giant sarcomeric protein expressed in striated muscles known to establish several interactions with other proteins of the sarcomere, but also with proteins of the sarcoplasmic reticulum and costameres. Here, we report experiments aiming to better understand the contribution of obscurin to skeletal muscle fibers, starting with a detailed characterization of the diaphragm muscle function, which we previously reported to be the most affected muscle in obscurin (Obscn) KO mice. Twitch and tetanus tension were not significantly different in the diaphragm of WT and Obscn KO mice, while the time to peak (TTP) and half relaxation time (HRT) were prolonged. Differences in force-frequency and force-velocity relationships and an enhanced fatigability are observed in an Obscn KO diaphragm with respect to WT controls. Voltage clamp experiments show that a sarcoplasmic reticulum’s Ca2+ release and SERCA reuptake rates were decreased in muscle fibers from Obscn KO mice, suggesting that an impairment in intracellular Ca2+ dynamics could explain the observed differences in the TTP and HRT in the diaphragm. In partial contrast with previous observations, Obscn KO mice show a normal exercise tolerance, but fiber damage, the altered sarcomere ultrastructure and M-band disarray are still observed after intense exercise. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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  • Resultat 1-6 av 6

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