| 1. |
- Axelsson, Lars, et al.
(författare)
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Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival
- 2021
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Ingår i: International Archives of Otorhinolaryngology. - : Georg Thieme Verlag KG. - 1809-9777 .- 1809-4864. ; 25:3
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPVpositive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p = 0.036), and N stage (p = 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and ( chemo) radiation and primary (chemo)
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| 2. |
- Bruneau, Jonas, et al.
(författare)
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Exstirpation of symptomatic lingual thyroid with transoral robotic surgery (TORS): A promising novel treatment option
- 2022
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Ingår i: ACTA OTO-LARYNGOLOGICA CASE REPORTS. - : TAYLOR & FRANCIS LTD. - 2377-2484. ; 7:1, s. 48-51
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Tidskriftsartikel (refereegranskat)abstract
- Ectopic thyroid is a rare condition most often found at the base of the tongue, lingual thyroid (LT). The majority of patients are asymptomatic. Recently, transoral robotic surgery (TORS) has emerged as an option for definitive treatment. Here, we present a 20-year-old patient with symptomatic LT, treated with TORS-assisted surgery without adverse events and with depletion of symptoms. We advocate TORS as a very promising means to be considered when encountering the rare condition of symptomatic LT.
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| 3. |
- Frånlund, Karin, et al.
(författare)
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PANDAS - a rare but severe disorder associated with streptococcal infections; Awareness is needed
- 2023
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Ingår i: ACTA OTO-LARYNGOLOGICA CASE REPORTS. - : TAYLOR & FRANCIS LTD. - 2377-2484. ; 8:1, s. 104-107
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Tidskriftsartikel (refereegranskat)abstract
- PANDAS is an acronym for paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and is defined as a subgroup of PANS, Paediatric acute-onset neuropsychiatric syndrome. PANDAS is considered an autoimmune disease based on a streptococcal infection with a verified immune response. The onset is often dramatic, with symptoms of OCD developing within 24-48 h. Symptoms include both psychological symptoms and physical symptoms. Treatments of PANDAS must address both physical and psychiatric symptoms. Supplemental treatments for PANDAS include tonsillectomy to prevent further streptococcal infections. We present a case of PANDAS with the aim of raising awareness of its diagnosis. PANDAS is a rare condition with an impact on the patients quality of life; thus, awareness is needed. A multidisciplinary team is needed for diagnosis and treatment. Otorhinolaryngologists may play an important role in the well-being of these patients when performing tonsillectomy.
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| 4. |
- Talani, Charbél, et al.
(författare)
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A rare case of tonsillar mucoepidermoid carcinoma
- 2023
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Ingår i: ACTA OTO-LARYNGOLOGICA CASE REPORTS. - : TAYLOR & FRANCIS LTD. - 2377-2484. ; 8:1, s. 44-46
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Tidskriftsartikel (refereegranskat)abstract
- Mucoepidermoid carcinoma (MEC) is one of the most common histological malignant salivary gland tumors, it is most frequently diagnosed in the parotid gland. MEC is also diagnosed in the intra oral minor salivary glands. Only a few cases of tonsillar MEC have been reported. We present a rare case of mucoepidermoid carcinoma arising from the left pharyngeal tonsil. This case report shows that it is important to perform tonsillectomy when discovering neck metastasis of salivary gland tumors with unknown primary.
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| 5. |
- Talani, Charbél, et al.
(författare)
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Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study
- 2019
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:10
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Tidskriftsartikel (refereegranskat)abstract
- Background Cancers of the head and neck have a high mortality rate, and roughly 10% of the patients die within six months of diagnosis. To our knowledge little has been written about this group. We wished to identify risk factors for early death, to predict and monitor patients at risk better and, if possible, avoid unjustified major treatment. Methods and findings This population-based nationwide study from the Swedish Head and Neck Cancer Register (SweHNCR) included data from 2008–2015 and 9733 patients at potential risk of early death. A total of 925 (9.5%) patients died within six months. For every year older the patients became, the risk of early death increased by 2.3% (p<0.001). The relative risk of death was 3.37 times higher (237%) for patients with WHO score 1 compared with WHO score 0. A primary tumour in the hypopharynx correlated with a 24% increased risk over the oral cavity (p<0.024). Patients with stage IV disease had a 3.7 times greater risk of early death than those with stage I (p<0.001). As expected, a 12 times increased risk of early death was noted in the palliative treatment group, compared to the curative group. Limitations to this study were that the actual cause of death was not recorded in the SweHNCR, and that socioeconomic factors, alcohol consumption, smoking habits, and HPV status, were not reported in SweHNCR until 2015. However, the fact that this is a population-based nationwide study including 9733 patients compensates for some of these limitations. Conclusions Identification of patients at increased risk of early death shows that older patients with advanced disease, increased WHO score, primary tumour in the hypopharynx, and those given palliative treatment, are more likely than the others to die from head and neck cancer within six months of diagnosis. © 2019 Talani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| 6. |
- Talani, Charbél, et al.
(författare)
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Pretreatment fat-free mass index correlates with early death in patients with head and neck squamous cell carcinoma
- 2024
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Ingår i: Head and Neck. - : WILEY. - 1043-3074 .- 1097-0347.
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundA significant proportion of patients with head and neck squamous cell carcinoma (HNSCC) are malnourished at diagnosis. In this study, we investigated how pretreatment body mass index (BMI) and fat-free mass index (FFMI) correlate with early death, and whether these measurements are useful markers of prognosis for risk stratification of head and neck cancer patients.MethodsPatients (n = 404) with newly diagnosed, curable HNSCC and WHO performance status 0-2 were prospectively included and met with a study representative before treatment initiation, as well as up to four follow-up visits. All patients provided an estimate of body weight at 6 months prior to diagnosis. Bioelectrical impedance analysis (BIA) was performed for all patients before treatment initiation.ResultsMost patients had oropharyngeal (46%), oral cavity (28%), or laryngeal cancer (12%). Forty-five (11%) patients met the standardized criteria for malnutrition according to the Global Leadership Initiative on Malnutrition (GLIM) at diagnosis. FFMI at diagnosis was lower in patients who died within 6 and 12 months after the start of treatment than in patients who survived these time points (p = 0.035 and p = 0.005, respectively).ConclusionsIn this study, pretreatment FFMI was an independent prognostic factor for death within 6 and 12 months after the start of treatment in patients with HNSCC. Pretreatment BMI was not an independent risk factor for death within 6 and 12 months after treatment termination. Thus, FFMI may be useful for risk stratification of patients with head and neck cancer.
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