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1.	Scirica, BM, et al. (author) Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus 2013 In: The New England journal of medicine. - 1533-4406. ; 369:14, s. 1317-1326 Journal article (peer-reviewed)
2.	Forouzanfar, MH, et al. (author) Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 2016 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 388:10053, s. 1659-1724 Journal article (peer-reviewed)
3.	Ding, Hao, et al. (author) A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling 2004 In: NATURE GENETICS. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 36:10, s. 1111-1116 Journal article (peer-reviewed)
4.	Ding, Hao, et al. (author) A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. 2004 In: Nat Genet. - 1061-4036. ; 36:10, s. 1111-6 Journal article (peer-reviewed)abstract PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers. Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-) embryos developed a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects. Complete loss of function of both ligands, therefore, phenocopied the loss of PDGFR-alpha function, suggesting that both PDGF-A and PDGF-C signal through PDGFR-alpha to regulate the development of craniofacial structures, the neural tube and mesodermal organs. Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated.

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Gupta, R. (2); Brown, J. (1); Jiang, Y. (1); Li, Y. (1); Price, D. (1); Walder, J. (1); show more...; Wang, H. (1); Wang, J. (1); Zhu, J. (1); Krueger, H. (1); Zhao, Y. (1); Zhou, M. (1); Lu, J. (1); Nilsson, J. (1); Albert, M (1); Fischer, H. (1); Conway, J. (1); Moore, R. (1); Jain, S. (1); Robinson, S. (1); Bose, S. (1); Ma, R. (1); Das, D. (1); Gupta, V. (1); Kim, D. (1); Schneider, R. (1); Weiderpass, E (1); Horton, K. (1); Kivipelto, M (1); Wood, J. (1); Hoffman, E. (1); Dellborg, M (1); Larsson, Anders (1); Bao, Y. (1); Diaz, M. (1); Taylor, R. (1); Weiss, R. (1); Svensson, M. (1); Uthman, OA (1); Abbafati, C (1); Abbas, KM (1); Abd-Allah, F (1); Abu-Raddad, LJ (1); Adedeji, IA (1); Afshin, A (1); Agardh, EE (1); Agrawal, A (1); Al-Aly, Z (1); Alam, K (1); Alla, F (1); show less...

University: University of Gothenburg (2); Uppsala University (2); Karolinska Institutet (2); Lund University (1); Högskolan Dalarna (1)

Language: English (4)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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