| 1. |
- Mi, Yushuai, et al.
(författare)
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Down-regulation of Barx2 predicts poor survival in colorectal cancer
- 2016
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0006-291X .- 1090-2104. ; 478:1, s. 67-73
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Tidskriftsartikel (refereegranskat)abstract
- Human BarH-like homeobox 2 (Barx2), a homeodomain factor of the Bar family, has an important role in controlling the expression of cell adhesion molecules and has been reported in an increasing array of tumor types except colorectal cancer (CRC). The purpose of the current study was to characterize the expression of Barx2 and assess the clinical significance of Barx2 in CRC. First, we analyzed the expression of Barx2 in two independent public datasets from Oncomine. Subsequently, we evaluated Barx2 mRNA and protein expression by quantitative real-time PCR and western blotting, respectively. It was determined that Barx2 expression was lower in tumor tissues than in adjacent non-tumorous colorectal tissues of CRC patients, consistent with results from the public datasets. Subsequently, a tissue microarray containing 196 CRC specimens was evaluated for Barx2 expression by immunohistochemical staining. It was found that low expression of Barx2 significantly correlated with TNM stage, AJCC stage, differentiation, and relapse in patients with CRC. Patients with lower levels of Barx2 expression showed reduced disease-free survival and overall survival. Furthermore, a trend toward shorter overall survival in the patient group with Barx2-negative tumors independent of advanced AJCC stage and poor differentiation was determined by Kaplan-Meier survival analysis. Based on univariate and multivariate analyses, Barx2 expression was an independent prognostic factor for determining CRC prognosis. Taken together, low Barx2 expression was associated with the progression of CRC and could serve as a potential independent prognostic biomarker for patients with CRC. (C) 2016 The Authors. Published by Elsevier Inc.
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| 2. |
- Mi, Yushuai, et al.
(författare)
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Downregulation of homeobox gene Barx2 increases gastric cancer proliferation and metastasis and predicts poor patient outcomes
- 2016
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Ingår i: Oncotarget. - : IMPACT JOURNALS LLC. - 1949-2553. ; 7:37, s. 60593-60608
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Tidskriftsartikel (refereegranskat)abstract
- Barx2 is a Bar family homeodomain transcription factor shown to play a critical role in cell adhesion and cytoskeleton remodeling, key processes in carcinogenesis and metastasis. Using quantitative real-time PCR, Western blotting, and immunohistochemistry, we found that Barx2 is expressed at lower levels in human gastric cancer (GC) tissues than in adjacent normal mucosa. In a multivariate analysis, Barx2 expression emerged as an independent prognostic factor for disease-free and overall survival. Kaplan-Meier survival analysis showed a trend toward even shorter overall survival in the patient group with Barx2-negative tumors, independent of advanced UICC stage and tumor relapse. Using in vitro and in vivo assays, we demonstrated that under normal conditions Barx2 inhibited GC cell proliferation and invasiveness through inhibition of the Wnt/beta-catenin signaling pathway. These findings indicate that reduction or loss of Barx2 dis-inhibits GC cell proliferation and invasion, and that reduction in Barx2 could serve as an independent prognostic biomarker for poor outcome in GC patients.
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| 3. |
- Peng, Jianhui, et al.
(författare)
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Achieving ultra-high electromagnetic wave absorption by anchoring Co0.33Ni0.33Mn0.33Fe2O4 nanoparticles on graphene sheets using microwave-assisted polyol method
- 2018
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Ingår i: Ceramics International. - : ELSEVIER SCI LTD. - 0272-8842 .- 1873-3956. ; 44:17, s. 21015-21026
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Tidskriftsartikel (refereegranskat)abstract
- The Co0.33Ni0.33Mn0.33Fe2O4/graphene nanocomposite for electromagnetic wave absorption was successfully synthesized from metal chlorides solutions and graphite powder by a simple and rapid microwave-assisted polyol method via anchoring the Co0.33Ni0.33Mn0.33Fe2O4 nanoparticles on the layered graphene sheets. The Fe3+, Co2+, Ni2+ and Mn2+ ions in the solutions were attracted by graphene oxide obtained from graphite and converted to the precursors Fe(OH)(3), Co(OH)(2), Ni(OH)(2), and Mn(OH)(2) under slightly alkaline conditions. After the transformations of the precursors to Co-Ni-Mn ferrites and conversion of graphene oxide to graphene under microwave irradiation at 170 degrees C in just 25 min, the Co0.33Ni0.33Mn0.33Fe2O4/graphene nanocomposite was prepared. The composition and structure of the nanocomposite were characterized by X-ray diffraction (XRD), inductive coupled plasma emission spectroscopy (ICP), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy (RS), transmission electron microscopy (TEM), etc. It was found that with the filling ratio of only 20 wt% and the thickness of 2.3 mm, the nanocomposite showed an ultra-wide effective absorption bandwidth (less than -10 dB) of 8.48 GHz (from 9.52 to 18.00 GHz) with the minimum reflection loss of - 24.29 dB. Compared to pure graphene sheets, Co0.33Ni0.33Mn0.33Fe2O4 nano particles and the counterparts reported in literature, the nanocomposite exhibited much better electromagnetic wave absorption, mainly attributed to strong wave attenuation, as a result of synergistic effects of dielectric loss, conductive loss and magnetic loss, and to good impedance matching. In view of its thin thickness, light weight and outstanding electromagnetic wave absorption property, the nanocomposite could be used as a very promising electromagnetic wave absorber.
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| 4. |
- Peng, Zhiwei, et al.
(författare)
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From ferronickel slag to value-added refractory materials : A microwave sintering strategy
- 2019
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Ingår i: Resources, Conservation and Recycling. - : ELSEVIER. - 0921-3449 .- 1879-0658. ; 149, s. 521-531
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Tidskriftsartikel (refereegranskat)abstract
- The present study proposes a novel strategy for preparation of refractory materials from potentially hazardous ferronickel slag by microwave sintering of the slag with addition of sintered magnesia in which a series of chemical reactions were involved. This strategy was developed based on examination of the phase transformations and microstructural changes of the slag during microwave sintering through X-ray diffraction (XRD) analysis and scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS) analysis, which determined the properties of refractory materials derived from the slag. It was shown that under microwave irradiation there existed rapid transformation of the olivine phase in the slag to high-melting point phases, including forsterite and spinels (e.g., magnesium iron chromate spinel, magnesium chromate spinel, and magnesium iron aluminate spinel). As a result, a high-quality refractory material with refractoriness of 1730 degrees C, bulk density of 2.80 g/cm(3), apparent porosity of 1.6%, and compressive strength of 206.62 MPa was obtained by microwave sintering of the slag at 1350 degrees C for only 20 min with addition of 25 wt % sintered magnesia. Because the microwave sintering strategy not only elevated the refractoriness by 70 degrees C, but also reduced the heating duration required by the conventional approach by 6 times, it demonstrated apparent technological superiority and wide application prospect in preparing superior-quality refractory materials from ferronickel slag and relevant industrial waste, which contributed to conservation of resources and energy as well as environmental protection.
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| 5. |
- Ye, Lei, et al.
(författare)
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Toward environmentally friendly direct reduced iron production : A novel route of comprehensive utilization of blast furnace dust and electric arc furnace dust
- 2021
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Ingår i: Waste Management. - : Elsevier. - 0956-053X .- 1879-2456. ; 135, s. 389-396
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Tidskriftsartikel (refereegranskat)abstract
- In this study, a novel method for producing direct reduced iron (DRI) powders based on microwave-assisted self reduction of core-shell composite pellets composed of blast furnace (BF) dust and hazardous electric arc furnace (EAF) dust followed by magnetic separation was reported. The proper core-shell structure of the composite pellets was designed according to the rule of impedance matching and properties of BF dust and EAF dust by adjusting the thickness of shell (i.e., thickness of impedance matching layer) via controlling the C/O molar ratio of the raw materials from 0.55 to 0.70. The results showed that the EAF dust with high content of CaO was beneficial to the mechanical strength of green, dried, and metallized pellets (collected after reduction), while the BF dust with high content of carbon enabled sufficient microwave-assisted reduction of the pellets, facilitating subsequent magnetic separation and also the removal of zinc from EAF dust. By reduction of the core-shell BF dust-EAF dust composite pellets with the C/O molar ratio of 0.65 at 1050 degrees C for 15 min, the resulting metallized pellets showed superior reduction and magnetic separation indexes with higher removal percentages of zinc and lead, in comparison with conventional metallized pellets. The DRI powders obtained after magnetic separation had total iron content of 91.2 wt%, iron metallization degree of 95.8%, yield of 68.1%, and iron recovery of 88.0%. This study provided a good example for efficient and environmentally friendly comprehensive utilization of typical and hazardous wastes in the iron and steel industry.
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