| 1. |
- Meyer, E., et al.
(författare)
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The state of the art in beyond 5G distributed massive multiple-input multiple-output communication system solutions
- 2022
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Ingår i: Open Research Europe. - : F1000 Research Ltd. - 2732-5121. ; 2
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Forskningsöversikt (refereegranskat)abstract
- Beyond fifth generation (5G) communication systems aim towards data rates in the tera bits per second range, with improved and flexible coverage options, introducing many new technological challenges in the fields of network architecture, signal pro- cessing, and radio frequency front-ends. One option is to move towards cell-free, or distributed massive Multiple-Input Multiple-Output (MIMO) network architectures and highly integrated front-end solutions. This paper presents an outlook on be- yond 5G distributed massive MIMO communication systems, the signal processing, characterisation and simulation challenges, and an overview of the state of the art in millimetre wave antennas and electronics.
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| 2. |
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| 3. |
- Tanveer, M. K., et al.
(författare)
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Prevalence and chemo-therapeutical investigations of gastrointestinal nematodes in domestic pigeons in Lahore, Pakistan
- 2011
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Ingår i: Tropical Biomedicine. - 0127-5720. ; 28:1, s. 102-110
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Tidskriftsartikel (refereegranskat)abstract
- The prevalence of gastrointestinal nematodes was studied in 143 (80 male and 63 female) domestic pigeons. Faecal samples were collected to determine the gastrointestinal nematodes of domestic pigeons through qualitative and quantitative faecal examinations. A total of 48 (male 33 and 25 female) naturally infected domestic pigeons were divided into G(1) (albendzdole) and G(2) (fenbendazole) treatment-groups along with one control group (C). The overall prevalence of gastrointestinal nematodes was 40.5% (58/143) in domestic pigeons. Likewise, the prevalence of gastrointestinal nematodes in males and females was found 41.3% (33/58) and 39.7% (25/58) respectively. The overall prevalence of Capillaria obsignata and Ascaridia columbae was found to be 67.2% and 32.8%, respectively. The prevalence of C. obsignata and A. columbae in males was 72.7% (24/33) and 27.8% (9/33) and in females was 60% (15/25) and 40% (10/25), respectively. There was no significant sex related difference seen in the prevalence of C. obsignata (p>0.56) and A. columbae (p>0.40) in domestic pigeons, respectively. The overall efficacy of albendazole and fenbendazole was calculated to be 66% and 71%. A remarkable significant difference (p<0.05) was observed in eggs per gram before and after treatment in both G(1) and G(2) treated-groups. The efficacy of fenbendazole was found to be more significant (p<0.02) than albendazole.
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| 4. |
- Waldschläger, Kryss, et al.
(författare)
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Microplastics: What Can We Learn from Clastic Sediments?
- 2023
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Ingår i: Springer Water. - : Springer Nature. - 2364-6934 .- 2364-8198. ; , s. 105-116
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Microplastics research has gained momentum in the 21st century but lags behind the long-standing research on clastic sediment.An interdisciplinary review paper was conducted, comparing microplastics with natural sediments in terms of particle properties, transport processes, sampling techniques, and ecotoxicology. The paper identifies seven research goals to enhance our understanding of microplastics in freshwater environments while learning from sediment research. This extended abstract presents the core message of the review paper, emphasizing the need to improve descriptions of microplastic particles, understand their transport processes, develop standardized sampling methods, and study their ecotoxicological effects. The research goals outline specific tasks to achieve these objectives and emphasize the importance of comparing microplastics to sediments to gain insights into their toxicity. Addressing these research goals will contribute to a comprehensive understanding of microplastics and their impact on freshwater ecosystems. For detailed insights, the original paper should be consulted.
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| 5. |
- Bilal, Muhammad Sajjad, et al.
(författare)
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Computational Investigation of 1, 3, 4 Oxadiazole Derivatives as Lead Inhibitors of VEGFR 2 in Comparison with EGFR : Density Functional Theory, Molecular Docking and Molecular Dynamics Simulation Studies
- 2022
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Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 12:11
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Tidskriftsartikel (refereegranskat)abstract
- Vascular endothelial growth factor (VEGF) is an angiogenic factor involved in tumor growth and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the treatment of renal inflammatory diseases, acting via VEGFR 2 receptor. To date, most FDA-approved tyrosine kinase (TK) inhibitors have been reported as dual inhibitors of EGFR and VEGFR 2. The aim of the present study was to find the potent and selective inhibitor of VEGFR 2 specifically for the treatment of renal cancer. Fourteen previously identified anti-inflammatory compounds i.e., 1, 3, 4 oxadiazoles derivatives by our own group were selected for their anti-cancer potential, targeting the tyrosine kinase (TK) domain of VEGFR2 and EGFR. A detailed virtual screening-based study was designed viz density functional theory (DFT) study to find the compounds stability and reactivity, molecular docking for estimating binding affinity, SeeSAR analysis and molecular dynamic simulations to confirm protein ligand complex stability and ADMET properties to find the pharmacokinetic profile of all compounds. The DFT results suggested that among all the derivatives, the 7g, 7j, and 7l were chemically reactive and stable derivatives. The optimized structures obtained from the DFTs were further selected for molecular docking, and the results suggested that 7g, 7j and 7l derivatives as the best inhibitors of VEGFR 2 with binding energy values -46.32, -48.89 and -45.01 kJ/mol. The Estimated inhibition constant (IC50) of hit compound 7j (0.009 mu M) and simulation studies of its complexes confirms its high potency and best inhibitor of VEGFR2. All the derivatives were also docked with EGFR, where they showed weak binding energies and poor interactions, important compound 7g, 7j and 7i exhibited binding energy of -31.01, -33.23 and -34.19 kJ/mol respectively. Furthermore, the anticancer potential of the derivatives was confirmed by cell viability (MTT) assay using breast cancer and cervical cancer cell lines. At the end, the results of ADMET studies confirmed these derivatives as drug like candidates. Conclusively, the current study suggested substituted oxadiazoles as the potential anticancer compounds which exhibited more selectivity towards VEGFR2 in comparison to EGFR. Therefore, the identified lead molecules can be used for the synthesis of more potent derivatives of VEGFR2, along with extensive in vitro and in vivo experiments, that can be used to treat various cancers, especially renal cancers, and to prevent angiogenesis due to aberrant expression of VEGFR2.
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| 6. |
- Flores-Morales, Amilcar, et al.
(författare)
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Proteogenomic characterization of patient-derived xenografts highlights the role of REST in neuroendocrine differentiation of castration-resistant prostate cancer
- 2019
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Ingår i: Clinical Cancer Research. - 1078-0432. ; 25:2, s. 595-608
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: An increasing number of castration-resistant prostate cancer (CRPC) tumors exhibit neuroendocrine (NE) features. NE prostate cancer (NEPC) has poor prognosis, and its development is poorly understood. Experimental Design: We applied mass spectrometry–based proteomics to a unique set of 17 prostate cancer patient–derived xenografts (PDX) to characterize the effects of castration in vivo, and the proteome differences between NEPC and prostate adenocarcinomas. Genome-wide profiling of REST-occupied regions in prostate cancer cells was correlated to the expression changes in vivo to investigate the role of the transcriptional repressor REST in castration-induced NEPC differentiation. Results: An average of 4,881 proteins were identified and quantified from each PDX. Proteins related to neurogenesis, cell-cycle regulation, and DNA repair were found upregulated and elevated in NEPC, while the reduced levels of proteins involved in mitochondrial functions suggested a prevalent glycolytic metabolism of NEPC tumors. Integration of the REST chromatin bound regions with expression changes indicated a direct role of REST in regulating neuronal gene expression in prostate cancer cells. Mechanistically, depletion of REST led to cell-cycle arrest in G1, which could be rescued by p53 knockdown. Finally, the expression of the REST-regulated gene secretagogin (SCGN) correlated with an increased risk of suffering disease relapse after radical prostatectomy. Conclusions: This study presents the first deep characterization of the proteome of NEPC and suggests that concomitant inhibition of REST and the p53 pathway would promote NEPC. We also identify SCGN as a novel prognostic marker in prostate cancer.
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| 7. |
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| 8. |
- Islam, M. S., et al.
(författare)
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Augmenting the sensing aptitude of hydrogenated graphene by crafting with defects and dopants
- 2016
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 228, s. 317-321
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Tidskriftsartikel (refereegranskat)abstract
- Density functional theory (DFT) level calculations were performed to study the interaction of hydrogenated graphene (CH) monolayer towards methane (CH4) gas molecules. The structural, electronic and gas sensing properties of pure, defected and light metal-doped CH monolayer were investigated. For the pristine CH, the estimated binding energy of CH4 fell short of the desired physisorption range and limit its gas sensing application at ambient conditions. However, upon crafting defects on pure CH layer by introducing hydrogen vacancies, a sharp increase in adsorption energies were observed when the CH4 molecules approached the defected sites of CH. Further, the effect of metal doping was studied by uniformly distributing light metal adatoms on CH monolayer which significantly enhanced the CH4 adsorption. To have better accuracy in calculating adsorption energies, we have incorporated van der Waals type corrections to our calculations for these weakly interacting systems.
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| 9. |
- Khan, Farooq-Ahmad, et al.
(författare)
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Designing Functionally Substituted Pyridine-Carbohydrazides for Potent Antibacterial and Devouring Antifungal Effect on Multidrug Resistant (MDR) Strains
- 2023
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Ingår i: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 28:1
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Tidskriftsartikel (refereegranskat)abstract
- The emergence of multidrug-resistant (MDR) pathogens and the gradual depletion of available antibiotics have exacerbated the need for novel antimicrobial agents with minimal toxicity. Herein, we report functionally substituted pyridine carbohydrazide with remarkable antimicrobial effect on multi-drug resistant strains. In the series, compound 6 had potent activity against four MDR strains of Candida spp., with minimum inhibitory concentration (MIC) values being in the range of 16-24 mu g/mL and percentage inhibition up to 92.57%, which was exceptional when compared to broad-spectrum antifungal drug fluconazole (MIC = 20 mu g/mL, 81.88% inhibition). Substitution of the octyl chain in 6 with a shorter butyl chain resulted in a significant anti-bacterial effect of 4 against Pseudomonas aeruginosa (ATCC 27853), the MIC value being 2-fold superior to the standard combination of ampicillin/cloxacillin. Time-kill kinetics assays were used to discern the efficacy and pharmacodynamics of the potent compounds. Further, hemolysis tests confirmed that both compounds had better safety profiles than the standard drugs. Besides, molecular docking simulations were used to further explore their mode of interaction with target proteins. Overall results suggest that these compounds have the potential to become promising antimicrobial drugs against MDR strains.
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| 10. |
- Ragupathi, V., et al.
(författare)
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Enhanced electrochemical performance of LiMnBO3 with conductive glassy phase : a prospective cathode material for lithium-ion battery
- 2017
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Ingår i: Ionics (Kiel). - : Springer. - 0947-7047 .- 1862-0760. ; 23:7, s. 1645-1653
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Tidskriftsartikel (refereegranskat)abstract
- LiMnBO3 has been identified as a promising cathode material for next-generation lithium-ion batteries. In this study, LiMnBO3 along with glassy lithium borate material (LiMnBO3 (II)) is synthesized by sol-gel method. X-ray diffraction (XRD) analysis depicts the existence of LiBO2 glassy phase along with m-LiMnBO3 phase. Transmission electron microscopy (TEM) analysis confirms the presence of LiBO2 glassy phase. An enhanced electrical conductivity of 3.64 x 10(-7) S/cm is observed for LiMnBO3 (II). The LiBO2 glassy phase is found to promote the Li reaction kinetics in LiMnBO3 (II). The synthesized LiMnBO3 (II) delivers a first discharge capacity of 310 mAh g(-1) within a potential window of 1.5-4.5 V at C/10 rate. Further, a discharge capacity of 186 mAh g(-1) at the 27th cycle shows a better cycle performance. The enhanced capacity is due to the presence of LiBO2 glassy phase and more than one Li-ion transfer in the lithium-rich stoichiometry of LiMnBO3 (II). Density functional theory calculation reveals the exact electronic structure of m-LiMnBO3 with a band gap of 3.05 eV. A charge transfer mechanism is predicted for delithiation process of m-LiMnBO3.
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