| 1. |
- Yang, Bo, et al.
(författare)
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Seeking community structure in networks via biogeography-based optimization with consensus dynamics
- 2019
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Ingår i: Physica A. - : Elsevier. - 0378-4371 .- 1873-2119. ; 527
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Tidskriftsartikel (refereegranskat)abstract
- Uncovering the community structure hidden in networks is crucial for understanding the function of networks. In this paper, an algorithm of biogeography-based optimization with consensus dynamics for community detection is proposed. The problems of seeking community structures in networks are exquisitely embedded into the framework of biogeography-based optimization. Hence the community structure unveiled in such an evolutionary and global manner is corresponding to the habitat with maximum modularity. We present a dynamical framework for generating initial distribution of solutions for the evolutionary process using consensus dynamics, which gives a reasonably good estimate of the community structure based on the topological information. Thereof, the proposed dynamical method of initialization promotes the efficiency of optimal solution search significantly, compared with the traditional random initialization. Then, the obtained partition is refined using biogeography-based optimization. In addition, a preferential selection strategy for generating the new solutions is developed based on local network topology. Furthermore, we also proposed an adaptive mutation operator that enhances the exploration ability of our evolutionary algorithm. The experimental results on both artificial random and real-world networks indicate the effectiveness and reliability of our algorithm. These findings shed new light on the role played by topological knowledge of networks extracted from consensus dynamics in the evolving optimization processes when finding complex mesoscale structures in networks such as community structure.
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| 2. |
- Yang, Zhen, et al.
(författare)
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Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people
- 2011
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Ingår i: Molecular Biology Reports. - : Springer Science and Business Media LLC. - 0301-4851 .- 1573-4978. ; 38:2, s. 1145-1150
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Tidskriftsartikel (refereegranskat)abstract
- Recent genome-wide association studies reported that GCKR rs780094 polymorphism is associated with elevated fasting serum triglyceride levels and elevated levels of C-reactive protein (CRP). There are a ample of data on the association between circulating triglyceride, CRP concentrations and risk of non-alcoholic fatty liver (NAFLD). To determine whether the GCKR rs780094 polymorphism contributes to the development of non-alcoholic fatty liver, a case-control study was performed in 903 Chinese subjects. Among study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis IA degrees, 90 with steatosis hepatis IIA degrees and 28 with steatosis hepatis IIIA degrees) and 467 controls were genotyped by using TaqMan allelic discrimination assays. We confirmed the association of GCKR rs780094 with NAFLD in Chinese people (OR = 1.607, 95% CI 1.139-2.271, P ([dom]) = 7.2 x 10(-3)). In this study, polymorphism in GCKR rs780094 was not significantly associated with the degree of fatty infiltration of the liver. In addition, the T-allele of GCKR rs780094 was significantly associated with increasing fasting triglyceride (P ([add]) = 3.8 x 10(-4)) and CRP (P ([add]) = 2.9 x 10(-4)) concentrations after adjusting for age, gender, and BMI. The association with NAFLD remained significant after adjustment for triglyceride, while adjustment for CRP abolished the association. Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people. The effect of genotype on NAFLD is probably mediated through chronic low-grade systemic inflammation rather than through dislipidemia.
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| 3. |
- Yang, Zhen, et al.
(författare)
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PPARG gene Pro12Ala variant contributes to the development of non-alcoholic fatty liver in middle-aged and older Chinese population
- 2012
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Ingår i: Molecular and Cellular Endocrinology. - : Elsevier BV. - 1872-8057 .- 0303-7207. ; 348:1, s. 255-259
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Tidskriftsartikel (refereegranskat)abstract
- Oxidative stress has been suggested to contribute to the development of non-alcoholic fatty liver disease (NAFLD). Peroxisome proliferator-activated receptor gamma (PPAR-gamma) heterozygous mice and Pro12Ala (C/G) polymorphism in PPARG exhibited increased resistance to oxidative stress. Smoking increases the production of reactive oxygen species, which could accelerates oxidative stress under overnutrition. To explore whether the C/G polymorphism, alone or in combination with smoking, may promote the development of non-alcoholic fatty liver, a case-control study was performed in 903 Chinese subjects. Among the study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis I degrees, 90 with steatosis hepatis II degrees and 28 with steatosis hepatis III degrees) and 467 controls were genotyped by using TaqMan allelic discrimination assays. After adjusting for confounders, the C/C genotype significantly associated with NAFLD (OR = 1.87, 95%CI 1.13-2.85, p = 0.009); smoking was also an independent risk factor for NAFLD (OR = 1.69, 95%CI 1.18-2.43, p = 0.025). In addition, we found possible synergistic effects, the higher risk group (smokers with the C/C genotype) showed 3.75 times higher risk of NAFLD than the low-risk group (non-smokers with C/G genotype) in a multiple logistic analysis after adjusting for the confounders (p < 0.001), but no departure from additivity was found. Our results indicated that the C/C genotype and smoking were significant independent risk factors for NAFLD. The possible synergistic effects of genotype and smoking may promote the development of NAFLD by aggravating oxidative stress, which supports the hypothesis that oxidative stress contributes to the development of NAFLD. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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| 4. |
- Zhang, Hanzhi, et al.
(författare)
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Quantitative estimation of the contribution of dustsources to Chinese loess using detrital zircon U-Pbage patterns
- 2016
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Ingår i: Journal of Geophysical Research - Earth Surface. - 2169-9003 .- 2169-9011. ; 121:11, s. 2085-2099
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Tidskriftsartikel (refereegranskat)abstract
- The origin and provenance of the loess deposits of the Chinese Loess Plateau (CLP) are stilldebated. In order to pinpoint the dust sources, surface samples from the piedmont of the NortheasternTibetan Plateau, the Gobi Altai Mountains, and modern eolian dunes from the Tengger desert and Mu Ussand field were analyzed by using the detrital zircon dating technique. In order to quantitatively discriminatethe content of different potential sources, zircon grains of different ages were grouped according to theirtectonic origin. Zircon grains aged from 1300 to 550 Ma were assigned to the Northeastern Tibetan Plateau,and grains aged from 550 to 0 Ma to the Northeastern Tibetan Plateau or the Gobi Altai Mountains, or to acombination of the two. Zircon ages of around 2.8 Ga to 1.3 Ga may be a mixture of sources from theNortheastern Tibetan Plateau, Gobi Altai Mountains, or North China Craton. Sediments from the Tenggerdesert and Mu Us sand field consist of a mixture of the three sources and exhibit a high degree of spatialvariability in terms of their source. In the northern part of the two deserts, 43–83% of the sediments arederived from the Gobi Altai Mountains, while in the south, material from the Northeastern Tibetan Plateaucomprises 51–98% of the sediments. Loess deposits from the CLP also comprise a mixture of the threedifferent sources, with material from the Northeastern Tibetan Plateau making the dominant contribution(65–100%), with material from the North China Craton and the Gobi Altai Mountains comprising 0–35% and0–40% of the loess deposits, respectively. The contributions from the three sources to the loess deposits onCLP vary spatially. Application of the novel statistical method of provenance group analysis demonstratesthat the loess deposits comprise a mixture of material from a broad region of northern China and that theNortheastern Tibetan Plateau material makes the dominant contribution.
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