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- Tarstedt, M, et al.
(författare)
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A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix (R))-PDT in actinic keratosis of the face and scalp
- 2005
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 1651-2057 .- 0001-5555. ; 85:5, s. 424-428
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Tidskriftsartikel (refereegranskat)abstract
- Photodynamic therapy (PDT) with topical methyl aminolevulinate ( MAL) administered in two treatment sessions separated by 1 week is an effective treatment for actinic keratoses. This open prospective study compared the efficacy and safety of MAL-PDT given as a single treatment with two treatments of MAL-PDT 1 week apart. Two hundred and eleven patients with 413 thin to moderately thick actinic keratoses were randomized to either a single treatment with PDT using topical MAL ( regimen I; n=105) or two treatments 1 week apart ( regimen II; n=106). Each treatment involved surface debridement, application of Metvix(R) cream (160 mg/g) for 3 h, followed by illumination with red light using a light-emitting diode system ( peak wavelength 634 +/- 3 nm, light dose 37 J/cm(2)). Thirty-seven lesions (19%) with a non-complete response 3 months after a single treatment were re-treated. All patients were followed up 3 months after the last treatment. A total of 400 lesions, 198 initially treated once and 202 treated twice, were evaluable. Complete response rate for thin lesions after a single treatment was 93% (95% CI = 87 - 97%), which was similar to 89% ( 82 - 96%) after repeated treatment. Response rates were lower after single treatment of thicker lesions (70% ( 60 - 78%) vs 84% ( 77 - 91%)), but improved after repeated treatment (88% ( 82 - 94%)). The conclusion of this study is that single treatment with topical MAL-PDT is effective for thin actinic keratosis lesions; however, repeated treatment is recommended for thicker or non-responding lesions.
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- Tarstedt, M., et al.
(författare)
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[Increasing number of skin cancer cases--also among the younger]
- 2005
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Ingår i: Läkartidningen. - 0023-7205. ; 102:26-27, s. 1972-5
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Tidskriftsartikel (refereegranskat)abstract
- The incidence of skin cancer has been increasing for several years. This is the case in malignant melanoma as well as in squamous cell carcinoma and basal cell carcinoma. Skin cancer is most common among the elderly, but is now also more frequently found in younger people. Surgery is often the treatment of choice and this is still the case in malignant melanoma and most cases of squamous cell carcinoma. For basal cell carcinoma, Bowen's disease and actinic keratoses, however, alternative treatments should be considered. Today, dermatologists can offer patients with skin cancer several new treatments besides surgery. These new treatments seem to have the same efficacy but better cosmetic results compared to earlier treatments.
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