| 1. |
- Arrowsmith, CH, et al.
(författare)
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The promise and peril of chemical probes
- 2015
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Ingår i: Nature chemical biology. - : Springer Science and Business Media LLC. - 1552-4469 .- 1552-4450. ; 11:8, s. 536-541
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
- Daelman, Bo, et al.
(författare)
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Frailty and cognitive function in middle-aged and older adults with congenital heart disease
- 2024
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Ingår i: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 83:12, s. 1149-1159
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Tidskriftsartikel (refereegranskat)abstract
- Background: Life expectancy of patients with congenital heart disease (CHD) has increased rapidly, resulting in a growing and aging population. Recent studies have shown that older people with CHD have higher morbidity, health care use, and mortality. To maintain longevity and quality of life, understanding their evolving medical and psychosocial challenges is essential.Objectives: The authors describe the frailty and cognitive profile of middle-aged and older adults with CHD to identify predictor variables and to explore the relationship with hospital admissions and outpatient visits.Methods: Using a cross-sectional, multicentric design, we included 814 patients aged ≥40 years from 11 countries. Frailty phenotype was determined using the Fried method. Cognitive function was assessed by the Montreal Cognitive Assessment.Results: In this sample, 52.3% of patients were assessed as robust, 41.9% as prefrail, and 5.8% as frail; 38.8% had cognitive dysfunction. Multinomial regression showed that frailty was associated with older age, female sex, higher physiologic class, and comorbidities. Counterintuitively, patients with mild heart defects were more likely than those with complex lesions to be prefrail. Patients from middle-income countries displayed more prefrailty than those from higher-income countries. Logistic regression demonstrated that cognitive dysfunction was related to older age, comorbidities, and lower country-level income.Conclusions: Approximately one-half of included patients were (pre-)frail, and more than one-third experienced cognitive impairment. Frailty and cognitive dysfunction were identified in patients with mild CHD, indicating that these concerns extend beyond severe CHD. Assessing frailty and cognition routinely could offer valuable insights into this aging population.
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| 4. |
- Marimon Giovannetti, Laura, et al.
(författare)
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Investigation of tacking strategies using an America's Cup 45 catamaran simulator
- 2014
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Ingår i: Procedia Engineering. - : Elsevier Ltd. - 1877-7058. ; , s. 811-816
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Konferensbidrag (refereegranskat)abstract
- The recent America's Cup has demonstrated the extreme performance capability of the AC45 and AC72 catamarans. The high cost and risk of catastrophic failure has imposed restrictions on the availability of these boats for training. As a consequence the use of simulators to allow shore-based training becomes an attractive option. The aim of this study is to use a recently developed AC45 tacking simulator to investigate the optimum tack sequence by conducting a parametric study of user control inputs based on previously recorded time histories. The study will provide a better understanding of the influence of the input parameters on the tack and allow improved shore-based training programmes to be developed.
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| 5. |
- Olausson, Katrin
(författare)
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On Evaluation and Modelling of Human Exposure to Vibration and Shock on Planing High-Speed Craft
- 2015
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- High speed in waves, necessary in for instance rescue or military operations, often result in severe loading on both the craft and the crew. To maximize the performance of the high-speed craft (HSC) system that the craft and crew constitute, balance between these loads is essential. There should be no overload or underuse of crew, craft or equipment. For small high-speed craft systems, man is often the weakest link. The human exposure to vibration and shock results in injuries and other adverse health effects, which increase the risks for non-safe operations and performance degradation of the crew and craft system. To achieve a system in balance, the human acceleration exposure must be considered early in ship design. It must also be considered in duty planning and in design and selection of vibration mitigation systems.The thesis presents a simulation-based method for prediction and evaluation of the acceleration exposure of the crew on small HSC. A numerical seat model, validated with experimental full-scale data, is used to determine the crew's acceleration exposure. The input to the model is the boat acceleration expressed in the time domain (simulated or measured), the total mass of the seated human, and seat specific parameters such as mass, spring stiffness and damping coefficients and the seat's longitudinal position in the craft. The model generates seat response time series that are evaluated using available methods for evaluation of whole-body vibration (ISO 2631-1 \& ISO 2631-5) and statistical methods for calculation of extreme values.The presented simulation scheme enables evaluation of human exposure to vibration and shock at an early stage in the design process. It can also be used as a tool in duty planning, requirements specification or for design of appropriate vibration mitigation systems. Further studies is proposed within three areas: investigation of the actual operational profiles of HSC, further development of seat models and investigation of the prevailing injuries and health problems among the crew of HSC.
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