| 1. |
- Druker, Brian J., et al.
(författare)
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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
- 2006
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 355:23, s. 2408-2417
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The cause of chronic myeloid leukemia (CML) is a constitutively active BCR-ABL tyrosine kinase. Imatinib inhibits this kinase, and in a short-term study was superior to interferon alfa plus cytarabine for newly diagnosed CML in the chronic phase. For 5 years, we followed patients with CML who received imatinib as initial therapy. METHODS: We randomly assigned 553 patients to receive imatinib and 553 to receive interferon alfa plus cytarabine and then evaluated them for overall and event-free survival; progression to accelerated-phase CML or blast crisis; hematologic, cytogenetic, and molecular responses; and adverse events. RESULTS: The median follow-up was 60 months. Kaplan-Meier estimates of cumulative best rates of complete cytogenetic response among patients receiving imatinib were 69% by 12 months and 87% by 60 months. An estimated 7% of patients progressed to accelerated-phase CML or blast crisis, and the estimated overall survival of patients who received imatinib as initial therapy was 89% at 60 months. Patients who had a complete cytogenetic response or in whom levels of BCR-ABL transcripts had fallen by at least 3 log had a significantly lower risk of disease progression than did patients without a complete cytogenetic response (P<0.001). Grade 3 or 4 adverse events diminished over time, and there was no clinically significant change in the profile of adverse events. CONCLUSIONS: After 5 years of follow-up, continuous treatment of chronic-phase CML with imatinib as initial therapy was found to induce durable responses in a high proportion of patients. (ClinicalTrials.gov number, NCT00006343 [ClinicalTrials.gov].)
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| 2. |
- Fazey, Ioan, et al.
(författare)
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Transforming knowledge systems for life on Earth : Visions of future systems and how to get there
- 2020
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Ingår i: Energy Research & Social Science. - : Elsevier. - 2214-6296 .- 2214-6326. ; 70
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Tidskriftsartikel (refereegranskat)abstract
- Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent.
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| 3. |
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| 4. |
- Hibbett, David, et al.
(författare)
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Sequence-based classification and identification of Fungi
- 2016
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Ingår i: Mycologia. - 0027-5514. ; 108:6, s. 1049-1068
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Forskningsöversikt (refereegranskat)abstract
- Fungal taxonomy and ecology have been revolutionized by the application of molecular methods and both have increasing connections to genomics and functional biology. However, data streams from traditional specimen- and culture-based systematics are not yet fully integrated with those from metagenomic and metatranscriptomic studies, which limits understanding of the taxonomic diversity and metabolic properties of fungal communities. This article reviews current resources, needs, and opportunities for sequence-based classification and identification (SBCI) in fungi as well as related efforts in prokaryotes. To realize the full potential of fungal SBCI it will be necessary to make advances in multiple areas. Improvements in sequencing methods, including long-read and single-cell technologies, will empower fungal molecular ecologists to look beyond ITS and current shotgun metagenomics approaches. Data quality and accessibility will be enhanced by attention to data and metadata standards and rigorous enforcement of policies for deposition of data and workflows. Taxonomic communities will need to develop best practices for molecular characterization in their focal clades, while also contributing to globally useful datasets including ITS. Changes to nomenclatural rules are needed to enable valid publication of sequence-based taxon descriptions. Finally, cultural shifts are necessary to promote adoption of SBCI and to accord professional credit to individuals who contribute to community resources.
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| 5. |
- Hutten, Martin, et al.
(författare)
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Lichens and Lichenicolous Fungi of Yosemite National Park, California
- 2013
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Ingår i: North American Fungi. - : Pacific Northwest Fungi Project. - 1937-786X. ; 8:11, s. 1-47
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Tidskriftsartikel (refereegranskat)abstract
- We compiled literature, intensively studied 15 sites as a group, and collected opportunistically in other areas of the Yosemite National Park. We report a total of 562 species of lichenized fungi from the Park, adding 461 species to the total of 101 species reported for the Park by the National Park Service database. An additional 22 lichenicolous fungi are reported here. Two nonlichenized fungi associated with young living twigs of particular host species are also included. An additional 75 species that are known from nearby areas in the Sierra Nevada, but not yet from Yosemite, are listed. Fourteen species are apparently newly reported for the Sierra Nevada, with an additional 17 species new to California, and five species new to North America (Gyalidea fritzei, Pyrenopsis reducta, Lecanora pseudosarcopidoides, L. sarcopidoides, L. subravida). Two taxonomic changes are included here: Verrucaria carbonusta Breuss is newly described, and Lecidea fuscoatrina Hertel & Leuckert is synonymized under the earlier but neglected name, L. cascadensis H. Magn.
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| 7. |
- McGawley, Kerry, 1978-, et al.
(författare)
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The effect of short-term sprint-interval training on repeated-sprint ability
- 2010
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Ingår i: Journal of Science and Medicine in Sport. - 1440-2440 .- 1878-1861. ; 13:6, s. e52-
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The purpose of the present study was to investigate whether short-term sprint-interval training (SIT) would enhance repeated-sprint ability (RSA) via improvements in power output, work decrement and oxygen uptake in recovery. Methods: Eight male, recreational team-sport players (mean±SD age: 21±2 y, body mass: 78.1±4.3 kg) completed a repeated-sprint test (RST) and a graded cycle test to exhaustion for the evaluation of VO2max before and after two weeks of SIT. The RST consisted of 7×5-s cycle sprints interspersed with 25 s of passive recovery. Peak power output (PP), mean power output (MP), decrement in MP (MPdec) and total work done (TWD) were recorded. In addition, VO2 was measured during the 25-s passive recovery periods between each sprint. The SIT involved six sessions (three sessions per week) of 4, 5 or 6 × 30-s, all-out sprints interspersed with 4.5 min of light recovery. The number of sprint repetitions increased by one after every two training sessions. Results and conclusion: Although there was no change in PP for any of the 7×5-s sprints following SIT (P > 0.05) there were significant increases in MP for each of the 7×5-s sprints (P < 0.05) and in TWD during the RST (mean±SD: 7.6±3.0 versus 29.4±2.6 kJ from pre- to post-training; P < 0.05). The MPdec decreased from 12.4 ±6.8 to 7.4±2.9% from pre- to post-training (P < 0.05) but VO2 between sprints was unchanged (P > 0.05). Furthermore, VO2max was not different following training (45.7±7.7 versus 45.0±5.4 mLkg-1 min-1 from pre- to post-training; P > 0.05). These findings suggest that short-term SIT may be an effective intervention for improving RSA within team-sport athletes via increases in work done during each sprint and reductions in the decrement in work done over a series of sprints. This does not appear to be due to greater oxygen uptake during the 25-s recovery periods between sprints or improvements in peak power. Other metabolic adaptations to SIT that maintain muscle force during high-intensity exercise may explain the current findings.
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| 9. |
- Taylor, Robert K., et al.
(författare)
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Diagnostic challenges for the detection of emerging pathogens : A case study involving the incursion of Pseudomonas syringae pv. actinidiae in New Zealand
- 2014
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Ingår i: Detection and Diagnostics of Plant Pathogens. - Dordrecht : Springer. - 9789401790208 - 9789401790192 ; , s. 71-86
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In November 2010, Pseudomonas syringae pv. actinidiae (Psa) was detected for the first time in New Zealand. This finding triggered one of the largest surveillance and diagnostic programmes seen in New Zealand’s horticultural industry. During this response, over 912 kiwifruit orchards and 14,500 samples were screened and tested for the presence of Psa. The initial objectives of the response were to confirm the causal agent, determine disease prevalence and identify possible mechanisms of spread with the aim of identifying management options to contain the outbreak. Molecular diagnoses and characterisation of the Psa strains isolated during the response was conducted using a range of techniques that included qPCR, rep-PCR fingerprinting, multilocus sequence analysis, and next generation sequencing. The usefulness and challenges of using the molecular techniques available at the time for Psa detection and characterisation during the response are discussed. © Springer Science+Business Media Dordrecht 2014.
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| 10. |
- Yousef, Areej, et al.
(författare)
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“It would be nice if someone took the load off you” : Arabic-speaking new-Australian mothers and the challenges of heritage language maintenance
- 2018
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Ingår i: Journal of Home Language Research. - Uppsala. - 2537-7043. ; 3, s. 1-16
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Tidskriftsartikel (refereegranskat)abstract
- Despite a general expectation for immigrants to Australia to shift quickly to the use of English, many new-Australian families maintain strong attachments to their heritage languages. Little research has explored how recently arrived families of Arabic-speaking background in Australia preserve their heritage language while acquiring proficiency in English. In this paper, we report on part of a study that explored the family language policies of four Arab-Australian mothers as they negotiated their new language reality. Focus groups and semi-structured interviews revealed that the participating mothers considered it vitally important for their children to be proficient in both English and Arabic and they employed a range of strategies for developing their children’s bilingualism. However, they also acknowledged that maintaining their children’s heritage language could be difficult and stressful. Our paper offers insights into family language policy and the challenges of heritage language maintenance for bilingual immigrant mothers in assimilationist contexts.
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