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Sökning: WFRF:(Technau K)

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  • Drinnenberg, IA, et al. (författare)
  • EvoChromo: towards a synthesis of chromatin biology and evolution
  • 2019
  • Ingår i: Development (Cambridge, England). - : The Company of Biologists. - 1477-9129 .- 0950-1991. ; 146:19
  • Tidskriftsartikel (refereegranskat)abstract
    • Over the past few years, interest in chromatin and its evolution has grown. To further advance these interests, we organized a workshop with the support of The Company of Biologists to debate the current state of knowledge regarding the origin and evolution of chromatin. This workshop led to prospective views on the development of a new field of research that we term ‘EvoChromo’. In this short Spotlight article, we define the breadth and expected impact of this new area of scientific inquiry on our understanding of both chromatin and evolution.
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  • Stadler, R., et al. (författare)
  • Long-term survival benefit after adjuvant treatment of cutaneous melanoma with dacarbazine and low dose natural interferon alpha: A controlled, randomised multicentre trial
  • 2006
  • Ingår i: Acta Oncol. - : Informa UK Limited. - 0284-186X. ; 45:4, s. 389-99
  • Tidskriftsartikel (refereegranskat)abstract
    • In a prospective, controlled, randomised, multicentre study 252 patients with totally resected cutaneous melanoma (248 in stage II-III and 4 in stage IV) were either treated with two doses of dacarbazine (DTIC) followed by a 6-month treatment with 3 MU thrice weekly of highly purified natural interferon-alpha (n = 128; arm A) or received no adjuvant treatment (n = 124; arm B). Treatment was well tolerated. After a median follow-up of 8.5 years ITT analysis showed that the difference in survival was statistically significant with respect to melanoma-related deaths (HR = 0.65, CI = 0.46-0.97, p = 0.022) and close to significance with respect to overall survival (HR 0.71, CI 0.49-1.00, p = 0.052). The risk reduction of melanoma-associated death, calculated by Cox proportional hazards modelling, after adjusting for identified predictive variables, was almost 50% (p = 0.002). The overall efficacy of the treatment appeared to be mainly attributable to effects observed in patients with deep and/or metastasizing tumours (HR 0.60, CI 0.40-0.90, p = 0.013).
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5.
  • Technau-Hafsi, K, et al. (författare)
  • [Molecular diagnosis of hand eczema]
  • 2023
  • Ingår i: Dermatologie (Heidelberg, Germany). - 2731-7013. ; 74:6, s. 410-415
  • Tidskriftsartikel (refereegranskat)
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