| 1. |
- Purdue, Mark P, et al.
(författare)
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Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:1, s. 60-65
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Tidskriftsartikel (refereegranskat)abstract
- We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r² = 0.99 in controls), rs11894252 (P = 1.8 × 10⁻⁸) and rs7579899 (P = 2.3 × 10⁻⁹), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 × 10⁻¹⁴). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 × 10⁻⁸). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.
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| 2. |
- Aleksandrova, Krasimira, et al.
(författare)
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A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk
- 2015
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 107:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. Results: After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P-difference = .87) and after excluding case patients diagnosed within the first four follow-up years. Conclusions: These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.
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| 3. |
- Dittrich, Yvonne, et al.
(författare)
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Researching cooperation and communication in continuous software engineering
- 2018
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Ingår i: Proceedings 2018 ACM/IEEE 11th International Workshop on Cooperative and Human Aspects of Software Engineering, CHASE 2018. - New York, NY, USA : ACM. - 9781450357258 ; Part F137813, s. 87-90
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Konferensbidrag (refereegranskat)abstract
- Continuous Software Engineering (CSE) - -continuous development and deployment of software - -and DevOps - -the close cooperation or integration of operations and software development - -is about to change how software is developed. Together with the tighter integration of development and operations also with usage this will change coordination and collaboration both between IT professionals and between developers and users. In this short paper, we discuss the CHASE dimension of three core research themes that begin to crystallize in literature. This position paper is intended as a 'call to arms' for the CHASE community to study CSE.
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| 4. |
- Klünder, Jil, et al.
(författare)
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Catching up with Method and Process Practice: An Industry-Informed Baseline for Researchers
- 2019
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Ingår i: Proceedings - 2019 IEEE/ACM 41st International Conference on Software Engineering: Software Engineering in Practice, ICSE-SEIP 2019. ; May 2019, s. 255-264
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Konferensbidrag (refereegranskat)abstract
- Software development methods are usually not applied by the book.companies are under pressure to continuously deploy software products that meet market needs and stakeholders' requests. To implement efficient and effective development processes, companies utilize multiple frameworks, methods and practices, and combine these into hybrid methods. A common combination contains a rich management framework to organize and steer projects complemented with a number of smaller practices providing the development teams with tools to complete their tasks. In this paper, based on 732 data points collected through an international survey, we study the software development process use in practice. Our results show that 76.8% of the companies implement hybrid methods.company size as well as the strategy in devising and evolving hybrid methods affect the suitability of the chosen process to reach company or project goals. Our findings show that companies that combine planned improvement programs with process evolution can increase their process' suitability by up to 5%.
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| 5. |
- Klünder, Jil, et al.
(författare)
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Determining context factors for hybrid development methods with trained models
- 2020
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Ingår i: Proceedings - 2020 IEEE/ACM International Conference on Software and System Processes, ICSSP 2020. - New York, NY, USA : ACM.
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Konferensbidrag (refereegranskat)abstract
- © 2020 ACM. Selecting a suitable development method for a specific project context is one of the most challenging activities in process design. Every project is unique and, thus, many context factors have to be considered. Recent research took some initial steps towards statistically constructing hybrid development methods, yet, paid little attention to the peculiarities of context factors influencing method and practice selection. In this paper, we utilize exploratory factor analysis and logistic regression analysis to learn such context factors and to identify methods that are correlated with these factors. Our analysis is based on 829 data points from the HELENA dataset. We provide five base clusters of methods consisting of up to 10 methods that lay the foundation for devising hybrid development methods. The analysis of the five clusters using trained models reveals only a few context factors, e.g., project/product size and target application domain, that seem to significantly influence the selection of methods. An extended descriptive analysis of these practices in the context of the identified method clusters also suggests a consolidation of the relevant practice sets used in specific project contexts.
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| 6. |
- Kuhrmann, Marco, et al.
(författare)
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Preface
- 2018
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Ingår i: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). - 1611-3349 .- 0302-9743. ; 11271 LNCS, s. V-VI
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Kuhrmann, Marco, et al.
(författare)
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Walking through the method zoo: Does higher education really meet software industry demands?
- 2019
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Ingår i: Proceedings - 2019 IEEE/ACM 41st International Conference on Software Engineering: Software Engineering Education and Training, ICSE-SEET 2019. - : IEEE. ; , s. 1-11
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Konferensbidrag (refereegranskat)abstract
- Software engineering educators are continually challenged by rapidly evolving concepts, technologies, and industry demands. Due to the omnipresence of software in a digitalized society, higher education institutions (HEIs) have to educate the students such that they learn how to learn, and that they are equipped with a profound basic knowledge and with latest knowledge about modern software and system development. Since industry demands change constantly, HEIs are challenged in meeting such current and future demands in a timely manner. This paper analyzes the current state of practice in software engineering education. Specifically, we want to compare contemporary education with industrial practice to understand if frameworks, methods and practices for software and system development taught at HEIs reflect industrial practice. For this, we conducted an online survey and collected information about 67 software engineering courses. Our findings show that development approaches taught at HEIs quite closely reflect industrial practice. We also found that the choice of what process to teach is sometimes driven by the wish to make a course successful. Especially when this happens for project courses, it could be beneficial to put more emphasis on building learning sequences with other courses.
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| 8. |
- Kuhrmann, Marco, et al.
(författare)
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What Makes Agile Software Development Agile
- 2022
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Ingår i: IEEE Transactions on Software Engineering. - 0098-5589 .- 1939-3520. ; 48:9, s. 3523-3539
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Tidskriftsartikel (refereegranskat)abstract
- Together with many success stories, promises such as the increase in production speed and the improvement in stakeholders' collaboration have contributed to making agile a transformation in the software industry in which many companies want to take part. However, driven either by a natural and expected evolution or by contextual factors that challenge the adoption of agile methods as prescribed by their creator(s), software processes in practice mutate into hybrids over time. Are these still agile In this article, we investigate the question: what makes a software development method agile We present an empirical study grounded in a large-scale international survey that aims to identify software development methods and practices that improve or tame agility. Based on 556 data points, we analyze the perceived degree of agility in the implementation of standard project disciplines and its relation to used development methods and practices. Our findings suggest that only a small number of participants operate their projects in a purely traditional or agile manner (under 15%). That said, most project disciplines and most practices show a clear trend towards increasing degrees of agility. Compared to the methods used to develop software, the selection of practices has a stronger effect on the degree of agility of a given discipline. Finally, there are no methods or practices that explicitly guarantee or prevent agility. We conclude that agility cannot be defined solely at the process level. Additional factors need to be taken into account when trying to implement or improve agility in a software company. Finally, we discuss the field of software process-related research in the light of our findings and present a roadmap for future research.
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| 9. |
- Šmite, Darja, et al.
(författare)
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The Future Workplace : Characterizing the Spectrum of Hybrid Work Arrangements for Software Teams
- 2023
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Ingår i: IEEE Software. - : IEEE Computer Society. - 0740-7459 .- 1937-4194. ; 40:2, s. 34-41
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Tidskriftsartikel (refereegranskat)abstract
- The better-than-expected forced working from home (WFH) experiences coupled with investments enabling remote work during the pandemic motivated many employees to continue WFH occasionally, often, or entirely. Many organizations adjust their policies to increase flexibility as reported in numerous news outlets, articles, blogs, and channels dedicated to future workplace. The studies praise the flexibility given to individuals and the increase in the work-life balance but also warn about the alienation of staff members, decreased team cohesion and sense of belonging, as well as dilution of the corporate culture. This article systemizes a spectrum of emerging work arrangements for teams, including hybrid teams, partially aligned teams and, more importantly, variegated teams with fully aligned alternation of office presence. Our team typology is based on the practical insights from ‘Alpha,’ ‘InterSoft,’ Valtech, IBM, Brandwatch, and Ericsson and provides a nuanced vocabulary for organizations to start reasoning about the future work arrangements. IEEE
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| 10. |
- Tell, Paolo, et al.
(författare)
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Message from the General Chair and Program Co-Chairs
- 2020
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Ingår i: Proceedings - 2020 ACM/IEEE 15th International Conference on Global Software Engineering, ICGSE 2020. - : Association for Computing Machinery, Inc. - 9781450370936 ; , s. IX-X
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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