| 1. |
- Nielsen, Rasmus Oestergaard, et al.
(författare)
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Collagen content in the vastus lateralis and the soleus muscle following a 90-day bed rest period with or without resistance exercises
- 2015
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Ingår i: MLTJ - Muscles Ligaments and Tendons Journal. - : Edra SpA. - 2240-4554. ; 5:4, s. 305-309
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: spaceflight seems associated with deterioration of the function of the skeletal muscles. Since muscle collagen is critical for muscle function, an improved understanding of the content of the muscle collagen during long-term inactivity seems important. Bed-rest with in-bed resistance training serves as a proxy for the conditions in space. Therefore, ground-based studies may improve the understanding of the consequences of long-term inactivity.Purpose: the purpose is to compare the change in collagen protein in the vastus lateralis (VL) and the soleus (SOL) muscle amongst persons exposed to a 90-day bed rest with or without resistance exercise.Methods: an explorative analysis was completed based on data from a randomized, controlled trial.The intervention group (BRE, SOL n=4, VL n=8) performed supine-based squat exercises, whereas the controls (BE, SOL n=6, VL n=12) remained inactive during follow-up. Muscle biopsies from vastus lateralis and soleus were taken at baseline(pre) and after 90-days’ follow-up (post). Muscle collagen (μg collagen/mg protein) was quantified. Two-way repeated measurements ANOVA was used to compare the interaction between the intervention (BRE/BR) and time (pre/post) for each muscle.Results: the collagen content of VL was similar between pre and post in the BRE group (-3.8 μg collagen/mg protein [95% CI: -22.0; 14.4], p=0.68) while it rose amongst individuals in the BR group (14.9 μg collagen/mg protein [95% CI: -0.01; 29.7], p=0.05). The difference of 18.66 [95% CI: -6.5; 43.9] between BRE and BR across time was, however, not significant (p=0.14). No significant reduction in SOL muscle collagen content was observed from pre to post in the BR group (-9.3 μg collagen/mg protein [95% CI: -24.9; 6.4], p=0.25) or in the BRE group (-6.5 μg collagen/mg protein [95% CI: -25.6; 12.6], p=0.50). There was no difference in the effect of BR versus BRE over time (mean difference -2.78 μg collagen/mg protein[95% CI: -29.7; 24.1], p=0.82).Conclusion: muscle collagen content in the VL or SOL muscle does not seem to differ after a 90-day bed rest period with or without squat exercises.
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| 2. |
- Norrbrand, Lena
(författare)
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Acute and early chronic responses to resistance exercise using flywheel or weights
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Resistance exercise using weights typically offers constant external load during coupled shortening (concentric) and lengthening (eccentric) muscle actions in sets of consecutive repetitions until failure. However, the constant external load and the inherent capability of skeletal muscle to produce greater force in the eccentric compared with the concentric action, would infer that most actions are executed with incomplete motor unit involvement. In contrast, use of the inertia of flywheels to generate resistance allows for maximal voluntary force to be produced throughout the concentric action, and for brief episodes of greater eccentric than concentric loading, i.e. “eccentric overload”. Thus, it was hypothesized that acute flywheel resistance exercise would induce greater motor unit and muscle use, and subsequent fatigue, compared with traditional weight stack/free weight resistance exercise. Furthermore, it was hypothesized that flywheel training would induce more robust neuromuscular adaptations compared with training using weights. A total of 43 trained and untrained men were investigated in these studies.Knee extensor muscle activation, fatigue response and muscle use were assessed during exercises by recording electromyographic signals and by means of functional magnetic resonance imaging, respectively. Flywheel resistance exercise provoked maximal or near maximal muscle activation from the first repetition, induced robust fatigue, and prompted more substantial motor unit and muscle use than weight stack/free weight resistance exercise in both novice and resistance trained men. Both prior to and following five weeks of unilateral knee extension training, the eccentric muscle activation was greater with flywheel than weight stack training. Furthermore, weight stack training generated greater increases of dynamic strength and neural adaptations, while flywheel training generated more prominent hypertrophy of individual quadriceps muscles and greater improvement of maximal isometric strength. Hence, due to the preferential metabolic cost of the concentric rather than eccentric actions, the maximal activation through the entire range of the concentric action within each repetition of a set during flywheel resistance exercise probably evoked the marked fatigue, and prompted more substantial muscle use than resistance exercise using weights. Furthermore, while any cause‐effect relationship remains to be determined, results of the pesent study suggest that brief episodes of “eccentric overload” amplify muscular adaptations following concentriceccentric resistance training.
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| 3. |
- Skoglund, Elisabeth, et al.
(författare)
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Skeletal muscle morphology, satellite cells, and oxidative profile in relation to physical function and lifelong endurance training in very old men
- 2023
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Ingår i: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 134:2, s. 264-275
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Tidskriftsartikel (refereegranskat)abstract
- In the current study, we compared muscle morphology in three advanced aging cohorts that differed in physical function, includ-ing a unique cohort of lifelong endurance athletes. Biopsies from the vastus lateralis muscle of seven lifelong endurance athletes (EAs) aged 82-92 yr, and 19 subjects from the Uppsala Longitudinal Study of Adult Men (ULSAM) aged 87-91 yr were analyzed. ULSAM subjects were divided into high-(n = 9, HF) and low-(n = 10, LF) function groups based on strength and physical function tests. The analysis included general morphology, fiber type and cross-sectional area, capillarization, deficient cytochrome c oxi-dase (COX) activity, number of myonuclei and satellite cells, and markers of regeneration and denervation. Fibers with central nuclei and/or nuclear clumps were observed in all groups. EA differed from LF and HF by having a higher proportion of type I fibers, 52% more capillaries in relation to fiber area, fewer COX-negative fibers, and less variation in fiber sizes (all P < 0.05). There were no differences between the groups in the number of myonuclei and satellite cells per fiber, and no significant differ-ences between LF and HF (P > 0.05). In conclusion, signs of aging were evident in the muscle morphology of all groups, but neither endurance training status nor physical function influenced signs of regeneration and denervation processes. Lifelong en-durance training, but not higher physical function, was associated with higher muscle oxidative capacity, even beyond the age of 80.NEW & NOTEWORTHY Here we show that lifelong endurance training, but not physical function, is associated with higher mus-cle oxidative capacity, even beyond the age of 80 yr. Neither endurance training status nor physical function was significantly associated with satellite cells or markers of regeneration and denervation in muscle biopsies from these very old men.
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| 4. |
- Ainegren, Mats, 1963-
(författare)
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The rolling resistances of roller skis and their effects on human performance during treadmill roller skiing
- 2010
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Modern ski-treadmills allow cross-country skiers, biathletes and ski-orienteers to test their physical performance in a laboratory environment using classical and freestyle techniques on roller skis. For elite athletes the differences in performance between test occasions are quite small, thus emphasising the importance of knowing the roller skis’ rolling resistance coefficient, µR, in order to allow correct comparisons between the results, as well as providing the opportunity to study work economy between different athletes, test occasions and core techniques.Thus, one of the aims of this thesis was to evaluate how roller skis’ µR is related to warm-up, mass, velocity and inclination of the treadmill. It was also necessary to investigate the methodological variability of the rolling resistance measurement system, RRMS, specially produced for the experiments, with a reproducibility study in order to indicate the validity and reliability of the results.The aim was also to study physiological responses to different µR during roller skiing with freestyle and classical roller skis and techniques on the treadmill as a case in which all measurements were carried out in stationary and comparable conditions.Finally, the aim was also to investigate the work economy of amateurs and female and male junior and senior cross-country skiers during treadmill roller skiing, i.e. as a function of skill, age and gender, including whether differences in body mass causes significant differences in external power per kg due to differences in the roller skis’ µR.The experiments showed that during a warm-up period of 30 minutes, µR decreased to about 60-65% and 70-75% of its initial value for freestyle and classical roller skis respectively. For another 30 minutes of rolling no significant change was found. Simultaneous measurements of roller ski temperature and mR showed that stabilized mR corresponds to a certain running temperature for a given normal force on the roller ski. The study of the influence on mR of normal force, velocity and inclination produced a significant influence of normal force on mR, while different velocities and inclinations of the treadmill only resulted in small changes in mR. The reproducibility study of the RRMS showed no significant differences between paired measurements with either classical or the freestyle roller skis.The study of the effects on physiological variables of ~50% change in µR,showed that during submaximal steady state exercise, external power, oxygen uptake, heart rate and blood lactate were significantly changed, while there were non significant or only small changes to cycle rate, cycle length and ratings of perceived exertion. Incremental maximal tests showed that time to exhaustion was significantly changed and this occurred without a significantly changed maximal power, maximal oxygen uptake, maximal heart rate and blood lactate, and that the influence on ratings of perceived exertion was non significant or small.The final part of the thesis, which focused on work economy, found no significant difference between the four groups of elite competitors, i.e. between the two genders and between the junior and senior elite athletes. It was only the male amateurs who significantly differed among the five studied groups. The study also showed that the external power per kg was significantly different between the two genders due to differences in body mass and mR, i.e. the lighter female testing groups were roller skiing with a relatively heavier rolling resistance coefficient compared to the heavier testing groups of male participants.
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| 5. |
- Alkner, Björn A, et al.
(författare)
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Knee extensor and plantar flexor muscle size and function following 90 days of bed rest with or without resistance exercise.
- 2004
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Ingår i: European Journal of Applied Physiology. - : Springer Science and Business Media LLC. - 1439-6319 .- 1439-6327. ; 93:3, s. 294-305
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Tidskriftsartikel (refereegranskat)abstract
- Skeletal muscle atrophy and strength loss induced by short-term simulated spaceflight are offset or attenuated by resistance exercise (RE). This study compared the effects of plantar flexor and knee extensor RE on muscle size and function in 17 healthy men (aged 26–41years) subjected to 90 days 6 head-down-tilt bed rest with (BRE; n=8) or without (BR; n=9) RE. The RE program consisted of coupled maximal concentric and eccentric actions in the supine squat (4 sets of 7 repetitions) and calf press (4·14) every third day employing a gravity-independent flywheel ergometer (FW). Prior to, and following bed rest, muscle volume was assessed using magnetic resonance imaging. Similarly, muscle strength and power and surface lectromyographic (EMG) activity were determined during maximal actions using FW or isokinetic dynamometry. In BR, knee extensor and plantar flexor muscle volume decreased (P<0.05) 18% and 29%, respectively. Torque or force and power decreased (P<0.05) 31–60% (knee extension) and 37–56% (plantar flexion) while knee extensor and plantar flexor EMG activity decreased 31–38% and 28–35%, respectively following BR. Muscle atrophy in BRE was prevented (P>0.05; knee extensors) or attenuated ()15%; plantar flexors). BRE maintained task-specific force, power and EMG activity. The decrease in non-task-specific torque was less (P<0.05) than in BR. The present data imply that the triceps surae and quadriceps muscles show different responsiveness to long-term bed rest with or without resistance exercise. The results also suggest that designing in-flight resistance exercise protocols for space travellers is complex and must extend beyond preserving
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| 6. |
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| 7. |
- Alkner, Björn, et al.
(författare)
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Efficacy of a gravity-independent resistance exercise device as a countermeasure to muscle atrophy during 29-day bed rest.
- 2004
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Ingår i: Acta Physioloogica Scandinavica. - 0001-6772. ; 181:3, s. 345-357
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Tidskriftsartikel (refereegranskat)abstract
- This study determined changes in knee extensor and plantar flexor muscle volume during 29 days of bed rest with or without resistance exercise using a gravity-independent flywheel ergometer. METHODS: Seventeen men (26-41 years) were subjected to 29 days of bed rest with (n = 8) or without (n = 9) resistance exercise; Supine Squat (SS) and Calf Press (CP) performed every third day. Quadriceps and triceps surae muscle volume was determined before and after bed rest and force and power were measured during training. Prior to these interventions, reproducibility of this device for training and testing was assessed in 23 subjects who performed bilateral maximal concentric, eccentric and isometric (MVC) knee extensions and plantar flexions over repeated sessions with simultaneous measurements of force, power and electromyographic (EMG) activity. RESULTS: Quadriceps and triceps surae muscle volume decreased (P < 0.05) 10 and 16%, respectively, after 29 days bed rest. Exercise maintained quadriceps volume and mitigated triceps surae atrophy. Thus, either muscle showed different response across subject groups (P < 0.05). Force and power output during training were either maintained (P > 0.05) or increased (P < 0.05). EMG amplitude in the training mode was similar (SS; P > 0.05) or greater (CP; P < 0.05) compared with that elicited during MVC. Peak force and power test-retest coefficient of variation (CV) ranged 5-6% and 7-8% for SS and CP, respectively. CONCLUSION: The present data suggest that this resistance exercise paradigm counteracts quadriceps and abates the more substantial triceps surae muscle atrophy in bedridden subjects, and therefore should be an important asset to space travellers.
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