| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
- Bousquet, J, et al.
(författare)
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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
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Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
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Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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| 6. |
- Sarmiento Nova, Silvia J., et al.
(författare)
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Response Surface Method strategies coupled with NLFEA for structural reliability analysis of prestressed bridges
- 2021
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Ingår i: IABSE Congress Ghent 2021. - Zurich, Switzerland : International Association for Bridge and Structural Engineering (IABSE). ; , s. 1813-1822
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Konferensbidrag (refereegranskat)abstract
- The Response Surface Method (RSM) has become an essential tool to solve structural reliability problems due to its accuracy, efficacy, and facility for coupling with Nonlinear Finite Element Analysis (NLFEA). In this paper, some strategies to improve the RSM efficacy without compromising its accuracy are tested. Initially, each strategy is implemented to assess the safety level of a highly nonlinear explicit limit state function. The strategy with the best results is then identified and used to carry out a reliability analysis of a prestressed concrete bridge, considering the nonlinear material behavior through NLFEA simulation. The calculated value of ? is compared with the target value established in Eurocode for ULS. The results showed how RSM can be a practical methodology and how the improvements presented can reduce the computational cost of a traditional RSM giving a good alternative to simulation methods such as Monte Carlo.
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