| 1. |
- Kuci Emruli, Venera, et al.
(författare)
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Identification of a serum biomarker signature associated with metastatic prostate cancer
- 2021
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Ingår i: Proteomics - Clinical Applications. - : Wiley. - 1862-8346 .- 1862-8354. ; 15:2-3
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Improved early diagnosis and determination of aggressiveness of prostate cancer (PC) is important to select suitable treatment options and to decrease over-treatment. The conventional marker is total prostate specific antigen (PSA) levels in blood, but lacks specificity and ability to accurately discriminate indolent from aggressive disease. Experimental design: In this study, we sought to identify a serum biomarker signature associated with metastatic PC. We measured 157 analytes in 363 serum samples from healthy subjects, patients with non-metastatic PC and patients with metastatic PC, using a recombinant antibody microarray. Results: A signature consisting of 69 proteins differentiating metastatic PC patients from healthy controls was identified. Conclusions and clinical relevance: The clinical value of this biomarker signature requires validation in larger independent patient cohorts before providing a new prospect for detection of metastatic PC.
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| 2. |
- Ollinger, Lisa, et al.
(författare)
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A Reference Architecture for Service-oriented Control Procedures and its Implementation with SysML and Grafchart
- 2013
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Ingår i: IEEE 18th Conference on Emerging Technologies & Factory Automation (ETFA), 2013. - 1946-0740 .- 1946-0759. - 9781479908622 ; , s. 1-8
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Konferensbidrag (refereegranskat)abstract
- Innovative engineering methods are needed to enhance the adaptability and agility of industrial control procedures and concurrently manage their rising complexity. Service-oriented Architecture (SOA) constitutes a promising paradigm to meet these challenges. To apply the rather abstract SOA principles to industrial automation, a model-driven engineering method is presented in this paper. Therefore, a reference architecture is introduced providing a framework to structure and define services for control tasks in a convenient way. The application of the engineering method is supported by an implementation concept. It uses SysML during the design phase and the process modeling and control language Grafchart for the execution of service-oriented control procedures.
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| 3. |
- Theorin, Alfred, et al.
(författare)
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Service-oriented Process Control with Grafchart and the Devices Profile for Web Services
- 2012
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Ingår i: 14th IFAC Symposium on Information Control Problems in Manufacturing. - 9783902661982 ; , s. 799-804
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Konferensbidrag (refereegranskat)abstract
- To fulfill increasing requirements within the manufacturing sector, highly flexible and adaptable automation systems are needed. It is desirable to have one integrated approach that stretches from the process planning phase, through the implementation phase and all the way to the phase for execution of the process control logics. One promising approach is to use the concepts of service-oriented architectures within automation, here referred to as SOA-AT. As service technology, DPWS has proved to be the most suitable for realizing service based communication on device level. The paper shows how Grafchart, a graphical language aimed for sequential control applications, can support the development of DPWS applications, and how Grafchart can be used for process modeling and execution in the planning and execution phase. This constitutes a unique framework for the development and execution of SOA applications in accordance with the requirements for automatic control tasks. The paper also presents an industry-related experimental setup in which the SOA-AT concepts are demonstrated through the use of Grafchart.
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| 4. |
- Theorin, Alfred, et al.
(författare)
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Service-oriented Process Control with Grafchart and the Devices Profile for Web Services
- 2013
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Ingår i: Service Orientation in Holonic and Multi-agent Manufacturing and Robotics: Studies in Computational Intelligence. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 9783642358517 ; 472, s. 213-227
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Bokkapitel (refereegranskat)abstract
- To fulfill increasing requirements within the manufacturing sector, highly flexible and adaptable automation systems are needed. It is desirable to have one integrated approach that stretches from the process planning phase, through the implementation phase and all the way to the phase for execution of the process control logics. One promising approach is to use the concepts of service-oriented architectures within automation, here referred to as SOA-AT. As service technology, DPWS has proved to be the most suitable for realizing service based communication on device level. The paper shows how Grafchart, a graphical language aimed for sequential control applications, can support the development of DPWS applications, and how Grafchart can be used for process modeling and execution in the planning and execution phase. This constitutes a unique framework for the development and execution of SOA applications in accordance with the requirements for automatic control tasks. The paper also presents an industry-related experimental setup in which the SOA-AT concepts are demonstrated through the use of Grafchart.
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