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Sökning: WFRF:(Thiffault E)

  • Resultat 1-8 av 8
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2.
  • Kattge, Jens, et al. (författare)
  • TRY plant trait database - enhanced coverage and open access
  • 2020
  • Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
  • Tidskriftsartikel (refereegranskat)abstract
    • Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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3.
  • Liu, Z. G., et al. (författare)
  • Hemizygous variants in protein phosphatase 1 regulatory subunit 3F (PPP1R3F) are associated with a neurodevelopmental disorder characterized by developmental delay, intellectual disability and autistic features
  • 2023
  • Ingår i: Human Molecular Genetics. - 0964-6906 .- 1460-2083. ; 32:20, s. 2981-2995
  • Tidskriftsartikel (refereegranskat)abstract
    • Protein phosphatase 1 regulatory subunit 3F (PPP1R3F) is a member of the glycogen targeting subunits (GTSs), which belong to the large group of regulatory subunits of protein phosphatase 1 (PP1), a major eukaryotic serine/threonine protein phosphatase that regulates diverse cellular processes. Here, we describe the identification of hemizygous variants in PPP1R3F associated with a novel X-linked recessive neurodevelopmental disorder in 13 unrelated individuals. This disorder is characterized by developmental delay, mild intellectual disability, neurobehavioral issues such as autism spectrum disorder, seizures and other neurological findings including tone, gait and cerebellar abnormalities. PPP1R3F variants segregated with disease in affected hemizygous males that inherited the variants from their heterozygous carrier mothers. We show that PPP1R3F is predominantly expressed in brain astrocytes and localizes to the endoplasmic reticulum in cells. Glycogen content in PPP1R3F knockout astrocytoma cells appears to be more sensitive to fluxes in extracellular glucose levels than in wild-type cells, suggesting that PPP1R3F functions in maintaining steady brain glycogen levels under changing glucose conditions. We performed functional studies on nine of the identified variants and observed defects in PP1 binding, protein stability, subcellular localization and regulation of glycogen metabolism in most of them. Collectively, the genetic and molecular data indicate that deleterious variants in PPP1R3F are associated with a new X-linked disorder of glycogen metabolism, highlighting the critical role of GTSs in neurological development. This research expands our understanding of neurodevelopmental disorders and the role of PP1 in brain development and proper function.
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4.
  • Pelkmans, Luc, et al. (författare)
  • The role of sustainability requirements in international bioenergy markets
  • 2013
  • Ingår i: International Bioenergy Trade. - : Springer. - 9789400769816 ; , s. 125-149
  • Bokkapitel (refereegranskat)abstract
    • As the main driver for bioenergy is to enable society to transform to more sustainable fuel and energy production systems, it is important to safeguard that bioenergy deployment happens within certain sustainability constraints. There is currently a high number of initiatives, including binding regulations and several voluntary sustainability standards for biomass, bioenergy and/or biofuels. Within IEA Bioenergy studies were performed to monitor the actual implementation process of sustainability regulations and certification, evaluate how stakeholders are affected and envisage the anticipated impact on worldwide markets and trade. On the basis of these studies, recommendations were made on how sustainability requirements could actually support further bioenergy deployment. Markets would gain from more harmonization and cross-compliance. A common language is needed as ‘sustainability’ of biomass involves different policy arenas and legal settings. Policy pathways should be clear and predictable, and future revisions of sustainability requirements should be open and transparent. Sustainability assurance systems (both through binding regulations and voluntary certification) should take into account how markets work, in relation to different biomass applications (avoiding discrimination among end-uses and users). It should also take into account the way investment decisions are taken, administrative requirements for smallholders, and the position of developing countries.
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5.
  • Pelkmans, Luc, et al. (författare)
  • The role of sustainability requirements in international bioenergy markets
  • 2014
  • Ingår i: Lecture Notes in Energy. - Dordrecht : Springer Netherlands. - 2195-1292 .- 2195-1284. ; 17:1, s. 125-149
  • Tidskriftsartikel (refereegranskat)abstract
    • As the main driver for bioenergy is to enable society to transform to more sustainable fuel and energy production systems, it is important to safeguard that bioenergy deployment happens within certain sustainability constraints. There is currently a high number of initiatives, including binding regulations and several voluntary sustainability standards for biomass, bioenergy and/or biofuels. Within IEA Bioenergy studies were performed to monitor the actual implementation process of sustainability regulations and certification, evaluate how stakeholders are affected and envisage the anticipated impact on worldwide markets and trade. On the basis of these studies, recommendations were made on how sustainability requirements could actually support further bioenergy deployment. Markets would gain from more harmonization and cross-compliance. A common language is needed as 'sustainability' of biomass involves different policy arenas and legal settings. Policy pathways should be clear and predictable, and future revisions of sustainability requirements should be open and transparent. Sustainability assurance systems (both through binding regulations and voluntary certification) should take into account how markets work, in relation to different biomass applications (avoiding discrimination among end-uses and users). It should also take into account the way investment decisions are taken, administrative requirements for smallholders, and the position of developing countries.
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6.
  • Smith, C T, et al. (författare)
  • Opportunities to encourage mobilization of sustainable bioenergy supply chains
  • 2017
  • Ingår i: Wiley Interdisciplinary Reviews: Energy and Environment. - : Wiley. - 2041-8396 .- 2041-840X. ; 6:3
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2016 John Wiley & Sons, Ltd.Significant opportunities exist to reduce greenhouse gas emissions, increase domestic energy security, boost rural economies, and improve local environmental conditions through the deployment of sustainable bioenergy and bio-based product supply chains. There is currently a wide selection of possible feedstocks, a variety of conversion routes, and a number of different end products that can be produced at a range of scales. However, economic slowdown, low oil prices, lack of global political will, and lingering questions regarding land use change and the sustainability of bioenergy production systems provide a challenging global context to speed the pace of investment. The opinions expressed in this paper are derived from our collaboration within IEA Bioenergy to determine opportunities as well as barriers that need to be overcome to realize opportunities on a wider scale. This comprehensive and novel collaborative effort confirmed that feedstocks produced using logistically efficient production systems can be mobilized to make significant contributions to achieving global targets for bioenergy. At the same time, significant barriers to large-scale implementation exist in many regions. The mobilization potential identified in the study will depend on both increases in supply chain efficiencies and profits and strong policy support to increase stakeholder and investor confidence.
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7.
  • Thiffault, E, et al. (författare)
  • Challenges and Opportunities for the Mobilisation of Forest Bioenergy in the Boreal and Temperate Biomes
  • 2016
  • Ingår i: Mobilisation of Forest Bioenergy in the Boreal and Temperate Biomes. - 9780128045145 ; , s. 190-213
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • © 2016 Elsevier Inc. All rights reserved. This book identifies opportunities and challenges for the mobilisation of sustainable forest biomass from supply chains operating in the boreal and temperate biomes. The respective feedstock plays a critical role in meeting global deployment levels for bioenergy, which in turn are necessary to stabilise global greenhouse gas (GHG) emissions and atmospheric carbon levels. Many aspects of bioenergy supply chains (such as logistics and trade, supply chain variability, technology learning and transfer, governance, organisational structures) present both challenges and opportunities and relate to all three dimensions of sustainability. Energy and forest systems can be integrated across landscapes and organisations to establish attractive solutions guided by good governance of forest management and biomass use (eg, policies, regulations, standards and certification systems). Nevertheless, substantial gains in forest bioenergy mobilisation can only be achieved with an important increase in forest management intensity, causing a larger appropriation of forest net primary production (NPP). Such intensification would likely require fundamental shifts in the forest systems and considerable societal change, in some countries. A multifaceted policy effort to support a broad array of technological, structural and behavioural changes is needed to enable energy and industrial transitions and the development of supply chains that deliver feedstock to a range of conversion and utilisation routes.
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8.
  • Thiffault, E, et al. (författare)
  • Mobilisation of Forest Bioenergy in the Boreal and Temperate Biomes
  • 2016
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • © 2016 Elsevier Inc. All rights reserved. Mobilisation of Forest Bioenergy in the Boreal and Temperate Biomes: Challenges, Opportunities, and Case Studies features input from key international experts who identify and analyze the main opportunities and roadblocks for the implementation of sustainable forest biomass supply chains in the boreal and temperate regions. It draws from responses to surveys that were sent to specialists from different countries, compares models of bioenergy deployment, and discusses different types of bioenergy carriers. Efficiency and profitability of the supply chain are analyzed and the scale and level of confidence of feedstock inventory estimates are highlighted. Logistics and ecological and socio-economic footprints are also covered. This book provides a synthesis of the scientific and technical literature on specific aspects of forest biomass supply chains, and quantifies future potentials in comparison to estimates provided by other sources and the targets for bioenergy production set by various organizations (IEA, IPCC, etc.). Finally, the book proposes recommendations for practitioners, policymakers, and future research. This approach makes the book especially relevant for professionals, policymakers, researchers, and graduate students in the field of bioenergy conversion and management, as well as those interested in sustainable management of natural resources. Presents foundational theory, examples and lessons learned, drawing on scientific and technical literature, as well as surveys conducted among stakeholders from various countries of the boreal and temperate biomes Provides best practices, insights, and recommendations through an integrative framework that encompasses various aspects of forest biomass supply chain, at different scales, and looking at a broad geographical and geopolitical range Compares contrasting history, policy context, and level of forest bioenergy development in several countries through several case studies Analyzes the efficiency and profitability of the supply chain, highlighting the scale and level of confidence of feedstock inventory estimates
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