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- Aardal-Eriksson, Elisabeth, et al.
(författare)
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Salivary cortisol, posttraumatic stress symptoms, and general health in the acute phase and during 9-month follow-up
- 2001
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Ingår i: Biological Psychiatry. - 0006-3223 .- 1873-2402. ; 50:12, s. 986-993
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Tidskriftsartikel (refereegranskat)abstract
- Background: Because traumatic events are unpredictable, there are few studies of psychobiological states immediately following such events. Our study aimed to determine the relation of salivary cortisol to psychologic distress immediately after a traumatic event and then during follow-up.Methods: Measurement of morning and evening salivary cortisol and ratings of psychologic distress (using the Impact of Events Scale [IES], the Post Traumatic Symptom Scale, and the General Health Questionnaire) were performed with 31 United Nations soldiers at three time points—5 days and 2 and 9 months—following a mine accident in Lebanon.Results: Five days after the accident, 15 subjects reported substantial posttraumatic distress according to the IES, as well as significantly lower morning and higher evening cortisol levels compared with the low-impact group. Within 9 months, the posttraumatic distress of the high-impact group was reduced, accompanied by an increase in morning and a decrease in evening cortisol levels. There were significant relationships between evening cortisol and all rating scales at the first and third time points.Conclusions: Subclinical posttraumatic stress following an adverse event can be measured biologically via salivary cortisol levels soon after the event.
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- Isaksson, Björn, et al.
(författare)
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Hepatic encephalopathy verified by psychometric testing and EEG in cirrhotic patients : Effects of mesocaval interposition shunt or sclerotherapy
- 2005
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Ingår i: HPB. - : Elsevier BV. - 1365-182X .- 1477-2574. ; 7:1, s. 65-72
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Tidskriftsartikel (refereegranskat)abstract
- Background. The aim of this randomised prospective study was to evaluate hepatic encephalopathy after mesocaval interposition shunt operation and after repeated endoscopic sclerotherapy. Methods. Forty-five patients with bleeding oesophageal varices due to liver cirrhosis were randomised to the two treatment groups, 24 to the shunt group and 21 to the sclerotherapy group. The patients were evaluated preoperatively regarding blood tests, hepatic encephalopathy as measured by electroencephalogram with spectral analysis and by a battery of psychometric tests. The direction of portal flow in the shunt group was investigated by shunt phlebography and ultrasonography with Doppler. During follow-up the same investigations were performed twice at median 6.7 and 14.7 months after operation. Results. No statistically significant difference was found during follow-up regarding blood tests and electroencephalography with spectral analysis. Although the preoperative psychometric tests showed that the shunt group performed significantly better than the sclerotherapy group, the first follow-up showed that the shunt group performed statistically worse than the sclerotherapy group in seven of the tests: Synonyms (measuring verbal ability), Block Design Test (measuring visuo-spatial ability), Memory for Design Test, Error Score (measuring memory function), Revised Visual Retention Test, correct answers and the same test error answers (measuring visuo-spatial memory, ability and immediate memory), Digit Symbol Test (measuring perceptual ability) and Trial Making Test B (measuring cognitive motor abilities). Conclusions. Patients treated by mesocaval interposition shunt showed a progressive general reduction in psychometric performance compared with patients treated with repeated sclerotherapy, in whom a general intellectual improvement was observed. This finding corresponds to the reverse direction of the preoperative portal flow to a hepatofugal pattern at first follow-up and at 12 months among two-thirds of the patients. © 2005 Taylor & Francis Group Ltd.
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- Spetz, Anna-Clara, 1973-, et al.
(författare)
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Momentary increase in plasma calcitonin gene-related peptide is involved in hot flashes in men treated with castration for carcinoma of the prostate
- 2001
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Ingår i: Journal of Urology. - 0022-5347 .- 1527-3792. ; 166:5, s. 1720-1723
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Tidskriftsartikel (refereegranskat)abstract
- PurposeIn women the vasodilatory neuropeptides calcitonin gene-related peptide and neuropeptide Y seem to be involved in menopausal hot flashes. We assessed whether plasma calcitonin gene-related peptide and neuropeptide Y change during hot flashes in men after castration.Materials and MethodsWe evaluated 10 men 61 to 81 years old who underwent castration due to cancer of the prostate and had frequent hot flashes for changes in plasma calcitonin gene-related peptide and neuropeptide Y during 1 day at the outpatient clinic. At least 5 blood samples were obtained between flashes and 4 were obtained during each flash. The samples were analyzed for calcitonin gene-related peptide and neuropeptide Y using radioimmunoassay technique. Hot flashes were objectively recorded by measuring peripheral skin temperature and skin conductance.ResultsPlasma calcitonin gene-related peptide increased 46% (95% confidence interval 21 to 71) during flashes in the 6 men in whom it was measurable. This change was statistically significant (p = 0.028). The concentration of neuropeptide Y was below the detection limit. Skin conductance and temperature increased significantly during flashes.ConclusionsCalcitonin gene-related peptide is involved in the mechanisms of hot flashes in men who underwent castration due to prostate carcinoma. Thus, there may be a similar mechanism of hot flashes in women and in men deprived of sex steroids.
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- Thorell, Lars-Håkan, 1943-, et al.
(författare)
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Improper study design precludes valid effect estimates in important suicide prevention research
- 2019
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Ingår i: International Journal of Methods in Psychiatric Research. - : John Wiley & Sons. - 1049-8931 .- 1557-0657. ; 28:3
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The observational study design for estimating accuracy of diagnostic tests for suicide risk in clinical work is not ideal, due to the effects of directed suicide prevention to the high-risk group. This is an example of the confounding by indication and protopathic bias, which lead to misinterpretation of the accuracy terms sensitivity and specificity. The simple arithmetic mechanism presented here, forces the conclusion that the accuracy estimates sensitivity and specificity, applied in open prospective trials of surmised diagnostic tests for suicide risk, cannot be normally interpreted as accuracy estimators. Further, the related concept "prediction of suicide" is shown to be fundamentally illogical and should not be used in the present context. All these statements reveal a far-reaching problem within the suicide prevention research: Conclusions regarding the usefulness of diagnostic tests of suicide risk in the vast previous research since decades deserve reinterpretation. Diagnostic tests per se, can possess highly qualitative properties in estimating important suicidological aspects regarding a patient, but, when studied in an open design study, it cannot be demonstrated. This problem concerns rating scales and any biological and psychological tests in medicine, when confounding factors, for example, suicide prevention, influence the outcome because of the test result per se.
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- Åström, Jan, 1934-, et al.
(författare)
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Graphometric variables of one's signature : II. Correlations with measures of perception, cognitive function, and personality
- 2008
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Ingår i: Perceptual and Motor Skills. - 0031-5125 .- 1558-688X. ; 107:1, s. 197-221
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Tidskriftsartikel (refereegranskat)abstract
- This study focused on interrelations between graphometric variables of the signature and measures of perception, cognitive function, and personality. Signatures from a sample of psychiatric and somatic outpatients (N=205) were analyzed into 23 graphometric variables and correlated with tests of IQ, cognitive and perceptual function, and personality. The results of a factor analysis of the graphometric, perceptual, and cognitive variables were very much like results from previous studies. Relationships with the graphometric variables can be described in five categories of intelligence, psychomotility, flexibility and speed of closure, and personality. Graphometric signs of Extraversion and Neuroticism were identified, and the two capitals in the signature indicated different psychological meanings. Measurements of the signature offered important personality information. © Perceptual and Motor Skills 2008.
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- Åström, Jan, 1934-, et al.
(författare)
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Graphometric variables of one's signature : I. Basic measures
- 2007
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Ingår i: Perceptual and Motor Skills. - 0031-5125 .- 1558-688X. ; 105:3 I, s. 733-752
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Tidskriftsartikel (refereegranskat)abstract
- This study focused on statistical properties and interrelationships of graphometric variables of the signatures of outpatients, 100 men and 119 women, remitted from somatic and psychiatric clinics for possible psychotherapy or for tests of IQ, personality, or brain lesions. The patients' signature on test forms were used. The type of handwriting was classified into Common, Print and Block letters, quantified in breadth, length, and area and grades of slant of minuscules ("lower-case letters") and majuscules ("upper- case"). Analysis indicated sex and age played roles in style of handwriting and size of letters, writing styles differed on most graphometric variables, and meaningful patterns of interrelationships among graphometric variables were specified by factor analysis. © Perceptual and Motor Skills 2007.
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