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- Zettergren, Anna, 1978, et al.
(författare)
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Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein
- 2019
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- A possible involvement of the gene IL1RAP (interleukin-1 receptor-associated protein) in the pathogenesis of Alzheimer's disease (AD) has been suggested in GWASs of cerebrospinal fluid (CSF) tau levels and longitudinal change in brain amyloid burden. The aim of this study was to examine previously implicated genetic markers in and near IL1RAP in relation to AD risk, CSF tau and A beta biomarkers, as well as cognitive decline, in a case (AD)-control study and an age homogenous population-based cohort. Genotyping of IL1RAP-related single nucleotide polymorphisms (SNPs), selected based on previous GWAS results, was performed. 3446 individuals (1154 AD cases and 2292 controls) were included in the analyses of AD risk, 1400 individuals (cognitively normal = 747, AD = 653) in the CSF biomarker analyses, and 861 individuals in the analyses of cognitive decline. We found no relation between IL1RAP-related SNPs and AD risk. However, CSF total-tau and phospho-tau were associated with the SNP rs9877502 (p = 6 x 10(-3) and p = 5 x 10(-4)). Further, nominal associations (p = 0.03-0.05) were found between three other SNPs and CSF biomarker levels, or levels of cognitive performance and decline in a sub-sample from the general population. These results support previous studies suggesting an association of IL1RAP with disease intensity of AD.
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| 3. |
- Alfredsson, Elin, 1985, et al.
(författare)
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Parenting programs during adolescence: Outcomes from universal and targeted interventions offered in real-world settings
- 2018
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564. ; 59:4, s. 378-391
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this naturalistic study was to explore short and long-term outcomes of five different group-based parenting programs offered to parents of 10 to 17-year-olds. Three hundred and fifteen parents (277 mothers and 38 fathers) who had enrolled in a parenting program (universal: Active Parenting, COPE; Connect; targeted: COMET; Leadership training for parents of teenagers [LFT]) answered questionnaires at three measurement waves (baseline, post-measurement, and one-year follow-up). The questions concerned parenting style, parental mental health, family climate and adolescent mental health. Results revealed small to moderate changes in almost all outcome variables and in all parenting programs. Overall, parents in COMET reported the largest short and long-term changes. No substantial differences in change were seen between the other programs. The results support the general effectiveness of parenting programs for parents of adolescents.
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| 4. |
- Andersson, Anton, et al.
(författare)
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Testing the personality differentiation by intelligence hypothesis in a representative sample of Swedish hexagenerians
- 2022
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Ingår i: Journal of Research in Personality. - : Elsevier BV. - 0092-6566 .- 1095-7251. ; 99
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Tidskriftsartikel (refereegranskat)abstract
- The Personality Differentiation by Intelligence Hypothesis (PDIH) predicts larger trait-variances, and smaller across-trait covariances for individuals with higher intelligence. We tested these predictions using multiple-group confirmatory factor analyses (MG-CFA), while controlling for the potential confound of systematic method variance related to reversed items using a correlated trait, correlated method (CTCM) approach. Participants between the ages of 62 and 68 completed measures of personality (Mini-IPIP: Donnellan et al., 2006) and intelligence (Raven APM-12: Arthur & Day, 1994). After establishing strict measurement invariance (MI), we found no support for larger variances, and only minor support for lower trait covariances as related to higher intelligence. Overall, the findings provide scant support for the PDIH when controlling for systematic method variance.
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- Hansson, Isabelle, 1988, et al.
(författare)
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Changes in Life Satisfaction in the Retirement Transition: Interaction Effects of Transition Type and Individual Resources
- 2018
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Ingår i: Work, Aging and Retirement. - : Oxford University Press (OUP). - 2054-4642 .- 2054-4650. ; 4:4, s. 352-366
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Tidskriftsartikel (refereegranskat)abstract
- The impact of retirement on well-being varies between individuals, but also within individuals over time. Type of transition and individual differences in resource capability are two factors likely to influence the retirement adjustment process, but we still lack in our understanding of the importance of these factors in relation to each other. 'I he aim of this study was to investigate interaction effects of transition type and individual resources on changes in life satisfaction in the retirement transition. We studied changes in life satisfaction over 1 year in a sample of 3,471 older adults from the population-based HEalth, Ageing, and Retirement Transitions in Sweden (HEARTS) study. The sample included participants retiring gradually (n = 360) or fully (n = 346) between the two measurement points as well those continuously working (n = 1,860) or retired (n = 905) in both waves. Resources evaluated for their role in the transition included baseline measures of self-esteem, autonomy, social support, self-rated physical health, self-rated cognitive ability, and basic financial assets. Results from multiple group latent change score models showed that retirement transition type and individual differences in resource capability variously influenced changes in life satisfaction. The six resources accounted for a larger proportion of individual differences in change among those who retired between the two waves (21.2%) than in those whose retirement status remained unchanged (12.6%). In addition, a larger proportion of variability in changes in life satisfaction were explained in abrupt (31.4%) than in gradual (11.7%) retirement.
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